SIGLEC H Monoclonal Antibody (eBio440c), Functional Grade, eBioscience™ | Invitrogen 16-0333-38 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SIGLEC H Monoclonal Antibody (eBio440c), Functional Grade, eBioscience™

catalog :

16-0333-38

quantity :

5 mg

price :

US 2500.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

eBio440c

reactivity :

mouse

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

SIGLEC H Monoclonal Antibody (eBio440c), Functional Grade, eBioscience™

Catalog # :

16-0333-38

Quantity :

5 mg

Price :

US 2500.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 2 µg/test, Functional assay: Assay-Dependent

Species :

Mouse

Clone :

eBio440c

Isotype :

IgG2b, kappa

Storage :

4° C

Description :

Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG). It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 2 µg/test, Functional assay: Assay-Dependent

Aliases :

6430529G09Rik; sialic acid binding Ig-like lectin H; Siglec; Siglech; Siglec-H; SIGLEC-like protein