product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscience™
catalog :
16-0289-81
quantity :
50 µg
price :
116 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CD28.2
reactivity :
crab eating macaque, human, rhesus macaque
application :
flow cytometry, blocking or activating experiments
more info or order :
citations: 117
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 4a
Liu G, Yu Y, Feng F, Zhu P, Zhang H, Zhang D, et al. Human CD8+CD28- T suppressor cells expanded by common gamma chain (γc) cytokines retain steady allospecific suppressive capacity in vivo. BMC Immunol. 2020;21:23 pubmed publisher
  • flow cytometry; human; loading ...; fig 3a
Shi Y, Zhang P, Wang G, Liu X, Sun X, Zhang X, et al. Description of organ-specific phenotype, and functional characteristics of tissue resident lymphocytes from liver transplantation donor and research on immune tolerance mechanism of liver. Oncotarget. 2018;9:15552-15565 pubmed publisher
  • flow cytometry; human; 1 ug/ml; fig 2c
Meng Y, Zhou W, Jin L, Liu L, Chang K, Mei J, et al. RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization. Cell Death Dis. 2017;8:e3105 pubmed publisher
  • flow cytometry; human; loading ...; fig s2
Su S, Zou Z, Chen F, Ding N, Du J, Shao J, et al. CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer. Oncoimmunology. 2017;6:e1249558 pubmed publisher
  • blocking or activating experiments; human; fig 6a
Pageon S, Nicovich P, Mollazade M, Tabarin T, Gaus K. Clus-DoC: a combined cluster detection and colocalization analysis for single-molecule localization microscopy data. Mol Biol Cell. 2016;27:3627-3636 pubmed
  • blocking or activating experiments; human; fig 1
Pageon S, Tabarin T, Yamamoto Y, Ma Y, Nicovich P, Bridgeman J, et al. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proc Natl Acad Sci U S A. 2016;113:E5454-63 pubmed publisher
  • blocking or activating experiments; human; fig 1
Hahn S, Neuhoff A, Landsberg J, Schupp J, Eberts D, Leukel P, et al. A key role of GARP in the immune suppressive tumor microenvironment. Oncotarget. 2016;7:42996-43009 pubmed publisher
  • flow cytometry; human; fig 5
Su S, Hu B, Shao J, Shen B, Du J, Du Y, et al. CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. Sci Rep. 2016;6:20070 pubmed publisher
  • flow cytometry; rhesus macaque; fig 4
Bolton D, Pegu A, Wang K, McGinnis K, Nason M, Foulds K, et al. Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs. J Virol. 2016;90:1321-32 pubmed publisher
  • blocking or activating experiments; human; 1 ug/ml; fig 6c
Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, et al. The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells. Nat Immunol. 2015;16:1077-84 pubmed publisher
  • blocking or activating experiments; human; fig 3
Severson J, Serracino H, Mateescu V, Raeburn C, McIntyre R, Sams S, et al. PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer. Cancer Immunol Res. 2015;3:620-30 pubmed publisher
  • blocking or activating experiments; human; 1 ug/ml
Chauhan A, Chen C, Moore T, DiPaolo R. Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset. J Biol Chem. 2015;290:5127-40 pubmed publisher
  • blocking or activating experiments; human
Caramalho I, Nunes Silva V, Pires A, Mota C, Pinto A, Nunes Cabaço H, et al. Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus. J Autoimmun. 2015;56:98-110 pubmed publisher
  • flow cytometry; rhesus macaque
Fujita T, Burwitz B, Chew G, Reed J, Pathak R, Seger E, et al. Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques. J Immunol. 2014;193:5576-83 pubmed publisher
  • flow cytometry; rhesus macaque
Mylvaganam G, Velu V, Hong J, Sadagopal S, Kwa S, Basu R, et al. Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa. J Immunol. 2014;193:4527-36 pubmed publisher
  • flow cytometry; human
Mao C, Mou X, Zhou Y, Yuan G, Xu C, Liu H, et al. Tumor-activated TCR??? T cells from gastric cancer patients induce the antitumor immune response of TCR??? T cells via their antigen-presenting cell-like effects. J Immunol Res. 2014;2014:593562 pubmed publisher
  • flow cytometry; human
Peguillet I, Milder M, Louis D, Vincent Salomon A, Dorval T, Piperno Neumann S, et al. High numbers of differentiated effector CD4 T cells are found in patients with cancer and correlate with clinical response after neoadjuvant therapy of breast cancer. Cancer Res. 2014;74:2204-16 pubmed publisher
  • blocking or activating experiments; human; 1 ug/ml
Rodriguez M, Loyd C, Ding X, Karim A, MCDONALD D, Canaday D, et al. Mycobacterial phosphatidylinositol mannoside 6 (PIM6) up-regulates TCR-triggered HIV-1 replication in CD4+ T cells. PLoS ONE. 2013;8:e80938 pubmed publisher
  • flow cytometry; rhesus macaque; loading ...
Demberg T, Brocca Cofano E, Kuate S, Aladi S, Vargas Inchaustegui D, Venzon D, et al. Impact of antibody quality and anamnestic response on viremia control post-challenge in a combined Tat/Env vaccine regimen in rhesus macaques. Virology. 2013;440:210-21 pubmed publisher
  • flow cytometry; rhesus macaque; loading ...; fig 2a
Reuter M, Yuan S, Marx P, Kutzler M, Weiner D, Betts M. DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells. Hum Vaccin Immunother. 2012;8:1648-53 pubmed publisher
  • blocking or activating experiments; human
Qi Y, Operario D, Georas S, Mosmann T. The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin. PLoS ONE. 2012;7:e39072 pubmed publisher
  • flow cytometry; human; fig 3
Brucklacher Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E. Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. J Immunol. 2009;183:5494-501 pubmed publisher
  • flow cytometry; rhesus macaque
  • flow cytometry; crab eating macaque
Hokey D, Johnson F, Smith J, Weber J, Yan J, Hirao L, et al. Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques. Eur J Immunol. 2008;38:1435-45 pubmed publisher
  • blocking or activating experiments; human
Hoves S, Krause S, Schutz C, Halbritter D, Scholmerich J, Herfarth H, et al. Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells. J Immunol. 2006;177:2691-8 pubmed
  • blocking or activating experiments; human; 100 ng/ml
Quiroga M, Pasquinelli V, Martinez G, Jurado J, Zorrilla L, Musella R, et al. Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. J Immunol. 2006;176:5965-74 pubmed
Martínez García M, Ojeda Ojeda M, Rodríguez Martín E, Insenser M, Moncayo S, Alvarez Blasco F, et al. TLR2 and TLR4 Surface and Gene Expression in White Blood Cells after Fasting and Oral Glucose, Lipid and Protein Challenges: Influence of Obesity and Sex Hormones. Biomolecules. 2020;10: pubmed publisher
Pampusch M, Haran K, Hart G, Rakasz E, Rendahl A, Berger E, et al. Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations. Mol Ther Methods Clin Dev. 2020;16:1-10 pubmed publisher
Tanaskovic O, Verga Falzacappa M, Pelicci P. Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells. PLoS ONE. 2019;14:e0217345 pubmed publisher
Kim D, Kim H, Choi Y, Kim S, Lee J, Sung K, et al. Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer. Exp Mol Med. 2019;51:94 pubmed publisher
Serwas N, Hoeger B, Ardy R, Stulz S, Sui Z, Memaran N, et al. Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nat Commun. 2019;10:3106 pubmed publisher
Han L, Hu J, Ma B, Wen D, Zhang T, Lu Z, et al. IL-17A increases MHC class I expression and promotes T cell activation in papillary thyroid cancer patients with coexistent Hashimoto's thyroiditis. Diagn Pathol. 2019;14:52 pubmed publisher
Opstelten R, Slot M, Lardy N, Lankester A, Mulder A, Claas F, et al. Determining the extent of maternal-foetal chimerism in cord blood. Sci Rep. 2019;9:5247 pubmed publisher
Strecker J, Jones S, Koopal B, Schmid Burgk J, Zetsche B, Gao L, et al. Engineering of CRISPR-Cas12b for human genome editing. Nat Commun. 2019;10:212 pubmed publisher
Rataj F, Jacobi S, Stoiber S, Asang F, Ogonek J, Tokarew N, et al. High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy. Br J Cancer. 2019;120:79-87 pubmed publisher
Tran H, Herz C, Ruf P, Stetter R, Lamy E. Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes. Front Immunol. 2018;9:2949 pubmed publisher
Fiore A, Ugel S, De Sanctis F, Sandri S, Fracasso G, Trovato R, et al. Induction of immunosuppressive functions and NF-κB by FLIP in monocytes. Nat Commun. 2018;9:5193 pubmed publisher
Bethune M, Li X, Yu J, McLaughlin J, Cheng D, Mathis C, et al. Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules. Proc Natl Acad Sci U S A. 2018;115:E10702-E10711 pubmed publisher
Ding J, Zhou T, Zheng X, Wang X, Tong X, Luo C, et al. The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis. Acta Cardiol Sin. 2018;34:399-408 pubmed publisher
Yoshitomi H, Kobayashi S, Miyagawa Hayashino A, Okahata A, Doi K, Nishitani K, et al. Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. Nat Commun. 2018;9:3762 pubmed publisher
Idelson M, Alper R, Obolensky A, Yachimovich Cohen N, Rachmilewitz J, Ejzenberg A, et al. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Stem Cell Reports. 2018;11:681-695 pubmed publisher
Dijkstra K, Cattaneo C, Weeber F, Chalabi M, van de Haar J, Fanchi L, et al. Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids. Cell. 2018;174:1586-1598.e12 pubmed publisher
Zhang A, Yoon J, Kim Y, Scott D. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells. J Immunol. 2018;201:1434-1441 pubmed publisher
Zhang R, Sun Q, Chen Y, Sun X, Gu Y, Zhao Z, et al. Ts-Hsp70 induces protective immunity against Trichinella spiralis infection in mouse by activating dendritic cells through TLR2 and TLR4. PLoS Negl Trop Dis. 2018;12:e0006502 pubmed publisher
Cuadrado E, van den Biggelaar M, de Kivit S, Chen Y, Slot M, Doubal I, et al. Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity. Immunity. 2018;48:1046-1059.e6 pubmed publisher
Dias A, Correia A, Pereira M, Almeida C, Alves I, Pinto V, et al. Metabolic control of T cell immune response through glycans in inflammatory bowel disease. Proc Natl Acad Sci U S A. 2018;115:E4651-E4660 pubmed publisher
Inoue M, Niki M, Ozeki Y, Nagi S, Chadeka E, Yamaguchi T, et al. High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages. Sci Rep. 2018;8:6736 pubmed publisher
Compeer E, Kraus F, Ecker M, Redpath G, Amiezer M, Rother N, et al. A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation. Nat Commun. 2018;9:1597 pubmed publisher
Lee J, Bangayan N, Chai T, Smith B, Pariva T, Yun S, et al. Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Proc Natl Acad Sci U S A. 2018;115:E4473-E4482 pubmed publisher
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Alam M, Gaida M, Debnath S, Tagad H, Miller Jenkins L, Appella E, et al. Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation. PLoS Biol. 2018;16:e2004111 pubmed publisher
Pizzolla A, Nguyen T, Sant S, Jaffar J, Loudovaris T, Mannering S, et al. Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles. J Clin Invest. 2018;128:721-733 pubmed publisher
Khan S, Karges W, Cooper C, Crawley A. Hepatitis C virus core protein reduces CD8+ T-cell proliferation, perforin production and degranulation but increases STAT5 activation. Immunology. 2018;154:156-165 pubmed publisher
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Tyler C, McCarthy N, Lindsay J, Stagg A, Moser B, Eberl M. Antigen-Presenting Human γδ T Cells Promote Intestinal CD4+ T Cell Expression of IL-22 and Mucosal Release of Calprotectin. J Immunol. 2017;198:3417-3425 pubmed publisher
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Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller A, et al. D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes. Mol Cell Biol. 2017;37: pubmed publisher
Riou R, Bressollette Bodin C, Boutoille D, Gagne K, Rodallec A, Lefebvre M, et al. Severe Symptomatic Primary Human Cytomegalovirus Infection despite Effective Innate and Adaptive Immune Responses. J Virol. 2017;91: pubmed publisher
Cárcamo Orive I, Hoffman G, Cundiff P, Beckmann N, D Souza S, Knowles J, et al. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity. Cell Stem Cell. 2017;20:518-532.e9 pubmed publisher
Zhu H, Hu F, Sun X, Zhang X, Zhu L, Liu X, et al. CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus. Front Immunol. 2016;7:512 pubmed
Ribeiro S, Tesio M, Ribot J, Macintyre E, Barata J, Silva Santos B. Casein kinase 2 controls the survival of normal thymic and leukemic ?? T cells via promotion of AKT signaling. Leukemia. 2017;31:1603-1610 pubmed publisher
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Chen H, Händel N, Ngeow J, Muller J, Huhn M, Yang H, et al. Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells. J Allergy Clin Immunol. 2017;139:607-620.e15 pubmed publisher
Tang Z, Hao Y, Zhang E, Xu C, Zhou Y, Zheng X, et al. CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade. Mol Med Rep. 2016;14:1107-16 pubmed publisher
Jones R, Mueller S, O Connor R, Rimpel K, Sloan D, Karel D, et al. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog. 2016;12:e1005545 pubmed publisher
Kapoor Kaushik N, Hinde E, Compeer E, Yamamoto Y, Kraus F, Yang Z, et al. Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells. Front Immunol. 2016;7:83 pubmed publisher
Hu H, Wang H, Xiao Y, Jin J, Chang J, Zou Q, et al. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016;213:399-414 pubmed publisher
Soh K, Tario J, Colligan S, Maguire O, Pan D, Minderman H, et al. Simultaneous, Single-Cell Measurement of Messenger RNA, Cell Surface Proteins, and Intracellular Proteins. Curr Protoc Cytom. 2016;75:7.45.1-7.45.33 pubmed publisher
Liu C, Jiang J, Gao L, Wang X, Hu X, Wu M, et al. Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways. Arthritis Res Ther. 2015;17:340 pubmed publisher
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Hsu P, Santner Nanan B, Hu M, Skarratt K, Lee C, Stormon M, et al. IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1. J Immunol. 2015;195:3665-74 pubmed publisher
Elkord E, Abd Al Samid M, Chaudhary B. Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP. Oncotarget. 2015;6:20026-36 pubmed
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Kovacsovics Bankowski M, Chisholm L, Vercellini J, Tucker C, Montler R, Haley D, et al. Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities. J Immunother Cancer. 2014;2:38 pubmed publisher
Bertin S, Aoki Nonaka Y, de Jong P, Nohara L, Xu H, Stanwood S, et al. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014;15:1055-1063 pubmed publisher
Dang S, Xu H, Xu C, Cai W, Li Q, Cheng Y, et al. Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis. Autophagy. 2014;10:1301-15 pubmed publisher
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Hellinger R, Koehbach J, Fedchuk H, Sauer B, Huber R, Gruber C, et al. Immunosuppressive activity of an aqueous Viola tricolor herbal extract. J Ethnopharmacol. 2014;151:299-306 pubmed publisher
Pham V, Nakayama M, Itoh Y, Ishigaki H, Kitano M, Arikata M, et al. Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. PLoS ONE. 2013;8:e75910 pubmed publisher
Koelsch K, Wang Y, Maier Moore J, Sawalha A, Wren J. GFP affects human T cell activation and cytokine production following in vitro stimulation. PLoS ONE. 2013;8:e50068 pubmed publisher
Chicaybam L, Sodré A, Curzio B, Bonamino M. An efficient low cost method for gene transfer to T lymphocytes. PLoS ONE. 2013;8:e60298 pubmed publisher
Miller T, Kaur S, Ivins O Keefe K, Roberts D. Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation. Matrix Biol. 2013;32:316-24 pubmed publisher
Palin A, Ramachandran V, Acharya S, Lewis D. Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a. J Immunol. 2013;190:2682-91 pubmed publisher
Li M, Cao W, Liu H, Zhang W, Liu X, Cai Z, et al. MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway. PLoS ONE. 2012;7:e49841 pubmed publisher
Phadwal K, Alegre Abarrategui J, Watson A, Pike L, Anbalagan S, Hammond E, et al. A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells. Autophagy. 2012;8:677-89 pubmed publisher
Ioannou M, Alissafi T, Lazaridis I, Deraos G, Matsoukas J, Gravanis A, et al. Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease. J Immunol. 2012;188:1136-46 pubmed publisher
Miller T, Wang E, Gould S, Stein E, Kaur S, Lim L, et al. Hydrogen sulfide is an endogenous potentiator of T cell activation. J Biol Chem. 2012;287:4211-21 pubmed publisher
Sakane N, Kwon H, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, et al. Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS Pathog. 2011;7:e1002184 pubmed publisher
Birzele F, Fauti T, Stahl H, Lenter M, Simon E, Knebel D, et al. Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human. Nucleic Acids Res. 2011;39:7946-60 pubmed publisher
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Tario J, Muirhead K, Pan D, Munson M, Wallace P. Tracking immune cell proliferation and cytotoxic potential using flow cytometry. Methods Mol Biol. 2011;699:119-64 pubmed publisher
Pan W, Zhu S, Yuan M, Cui H, Wang L, Luo X, et al. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol. 2010;184:6773-81 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscience™
Catalog # :
16-0289-81
Quantity :
50 µg
Price :
116 USD
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent
Species :
Human
Clone :
CD28.2
Isotype :
IgG1, kappa
Storage :
4° C
Description :
CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent
Aliases :
antigen CD28; Cd28; CD28 antigen; CD28 antigen (Tp44); CD28 isoform; CD28 isoform 2; CD28 molecule; CD28 precursor protein; CD28 protein; CD28 protein precursor; CD28RNA; cell surface protein; CHT28; contains partial extracellular domain; costimulatory molecule B7 receptor CD28; EGK_04709; MGC138290; sCD28; soluble CD28; T44; T-cell costimulatory molecule CD28; T-cell costimulatory molecule Tp44; T-cell-specific surface glycoprotein CD28; T-cell-specific surface glycoprotein CD28 homolog; TP44
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA