This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD28 Monoclonal Antibody (JJ319), Functional Grade, eBioscience
catalog :
16-0280-81
quantity :
50 ug
price :
US 133.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
JJ319

The same clone is also sold as:
reactivity :
rat
application :
flow cytometry
citations: 5
Reference
Zhang J, Zhang Y, Xu T, Pan S, Nie G, Miao X, et al. Severe traumatic hemorrhagic shock induces compromised immune barrier function of the mesenteric lymph node leading to an increase in intestinal bacterial translocation. Am J Transl Res. 2017;9:2363-2373 pubmed
Oliveira L, Correia A, Cristina Costa A, Guerra Gomes S, Ferreirinha F, Magalhães Cardoso M, et al. Deficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis. Mediators Inflamm. 2015;2015:460610 pubmed publisher
Gu W, Xu W, Ding T, Guo X. Fringe controls naïve CD4(+)T cells differentiation through modulating notch signaling in asthmatic rat models. PLoS ONE. 2012;7:e47288 pubmed publisher
Wacker K, Gründemann C, Kern Y, Bredow L, Huber R, Reinhard T, et al. Inhibition of corneal inflammation following keratoplasty by birch leaf extract. Exp Eye Res. 2012;97:24-30 pubmed publisher
Zhang G, Liu Y, Guo H, Sun Z, Zhou Y. Triptolide promotes generation of FoxP3+ T regulatory cells in rats. J Ethnopharmacol. 2009;125:41-6 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD28 Monoclonal Antibody (JJ319), Functional Grade, eBioscience
Catalog # :
16-0280-81
Quantity :
50 ug
Price :
US 133.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Rat
Applications :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Species :
Rat
Clone :
JJ319
Isotype :
IgG1
Storage :
4 C
Description :
CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Aliases :
antigen CD28; CD28; CD28 antigen; CD28 antigen (Tp44); CD28 isoform; CD28 isoform 2; Cd28 molecule; CD28 precursor protein; CD28 protein; CD28 protein precursor; CD28RNA; cell surface protein; CHT28; contains partial extracellular domain; costimulatory molecule B7 receptor CD28; EGK_04709; MGC138290; sCD28; soluble CD28; T44; T-cell costimulatory molecule CD28; T-cell costimulatory molecule Tp44; T-cell-specific surface glycoprotein CD28; T-cell-specific surface glycoprotein CD28 homolog; TP44
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA