CD19 Monoclonal Antibody (MB19-1), Functional Grade, eBioscience™ | Invitrogen 16-0191-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD19 Monoclonal Antibody (MB19-1), Functional Grade, eBioscience™

catalog :

16-0191-025

quantity :

25 mg

price :

US 7500.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MB19-1

reactivity :

mouse

application :

immunoprecipitation, flow cytometry

citations: 10

Reference
BrandstÃ¤tter O, Schanz O, Vorac J, KÃ¶nig J, Mori T, Maruyama T, et al. Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor. Sci Rep. 2016;6:26091 pubmed publisher
Napier R, Norris B, Swimm A, Giver C, Harris W, Laval J, et al. Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity. PLoS Pathog. 2015;11:e1004770 pubmed publisher
Ueno M, Maeno T, Nishimura S, Ogata F, Masubuchi H, Hara K, et al. Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages. Nat Commun. 2015;6:6332 pubmed publisher
Kasper K, Zeppa J, Wakabayashi A, Xu S, Mazzuca D, Welch I, et al. Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner. PLoS Pathog. 2014;10:e1004155 pubmed publisher
Rommel P, Bosque D, Gitlin A, Croft G, Heintz N, Casellas R, et al. Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development. PLoS ONE. 2013;8:e69208 pubmed publisher
Zhong M, Veillette A. Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity. Mol Cell Biol. 2013;33:1223-32 pubmed publisher
Cohen N, Brennan P, Shay T, Watts G, Brigl M, Kang J, et al. Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nat Immunol. 2013;14:90-9 pubmed publisher
Bezman N, Kim C, Sun J, Min oo G, Hendricks D, Kamimura Y, et al. Molecular definition of the identity and activation of natural killer cells. Nat Immunol. 2012;13:1000-9 pubmed publisher
Melillo J, Song L, Bhagat G, Blazquez A, Plumlee C, Lee C, et al. Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function. J Immunol. 2010;184:2638-45 pubmed publisher
Chen G, Dimitriou I, La Rose J, Ilangumaran S, Yeh W, Doody G, et al. The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response. Mol Cell Biol. 2007;27:3109-22 pubmed

product information

Product Type :

Antibody

Product Name :

CD19 Monoclonal Antibody (MB19-1), Functional Grade, eBioscience™

Catalog # :

16-0191-025

Quantity :

25 mg

Price :

US 7500.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 2 µg/test, Functional assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent

Species :

Mouse

Clone :

MB19-1

Isotype :

IgA, kappa

Storage :

4° C

Description :

CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 2 µg/test, Functional assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent

Aliases :

AW495831; B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Cd19; CD19 antigen; CD19 molecule; CVID3; differentiation antigen CD19; Leu-12; T-cell surface antigen Leu-12