IL-15 Monoclonal Antibody (ct2nu), Functional Grade, eBioscience | Invitrogen 16-0157-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-15 Monoclonal Antibody (ct2nu), Functional Grade, eBioscience

catalog :

16-0157-82

quantity :

100 ug

price :

US 144.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ct2nu

reactivity :

human

application :

neutralization

citations: 8

Reference
Witkowski M, Tizian C, Ferreira Gomes M, Niemeyer D, Jones T, Heinrich F, et al. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature. 2021;600:295-301 pubmed publisher
Mysore V, Cullere X, Settles M, Ji X, Kattan M, Desjardins M, et al. Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens. Med (N Y). 2021;2:1050-1071.e7 pubmed publisher
Mysore V, Cullere X, Settles M, Ji X, Kattan M, Desjardins M, et al. Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens. bioRxiv. 2021;: pubmed publisher
Gupta R, Yan X, Barrientos J, Kolitz J, Allen S, Rai K, et al. Mechanistic Insights into CpG DNA and IL-15 Synergy in Promoting B Cell Chronic Lymphocytic Leukemia Clonal Expansion. J Immunol. 2018;201:1570-1585 pubmed publisher
Sattler A, Dang Heine C, Reinke P, Babel N. IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions. Eur J Immunol. 2015;45:2286-98 pubmed publisher
Huntington N, Legrand N, Alves N, Jaron B, Weijer K, Plet A, et al. IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med. 2009;206:25-34 pubmed publisher
Rowley J, Monie A, Hung C, Wu T. Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans. J Immunol. 2008;181:8237-47 pubmed
Fehniger T, Caligiuri M. Interleukin 15: biology and relevance to human disease. Blood. 2001;97:14-32 pubmed

product information

Product Type :

Antibody

Product Name :

IL-15 Monoclonal Antibody (ct2nu), Functional Grade, eBioscience

Catalog # :

16-0157-82

Quantity :

100 ug

Price :

US 144.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Human

Clone :

ct2nu

Isotype :

IgG1, kappa

Storage :

4 C

Description :

IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.

Immunogen :

Recombinant Human IL-15

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

AI503618; il 15; Il15; IL-15; ILN; Interleukin; interleukin 15; Interleukin15; interleukin-15; MGC9721; M-IL-15