product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscience
catalog :
16-0037-025
quantity :
25 mg
price :
US 9350.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
OKT3
reactivity :
human
application :
flow cytometry, blocking or activating experiments
more info or order :
citations: 228
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; 0.25 ug/ml; loading ...; fig 5d
Pinkert J, Boehm H, Trautwein M, Doecke W, Wessel F, Ge Y, et al. T cell-mediated elimination of cancer cells by blocking CEACAM6-CEACAM1 interaction. Oncoimmunology. 2022;11:2008110 pubmed publisher
  • flow cytometry; human; loading ...; fig 1a
Banki Z, Krabbendam L, Klaver D, Leng T, Kruis S, Mehta H, et al. Antibody opsonization enhances MAIT cell responsiveness to bacteria via a TNF-dependent mechanism. Immunol Cell Biol. 2019;97:538-551 pubmed publisher
Kendirli A, de la Rosa C, L xe4 mmle K, Eglseer K, Bauer I, Kavaka V, et al. A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model. Nat Neurosci. 2023;26:1713-1725 pubmed publisher
Lin M, Bhakdi S, Tan D, Lee J, Tai D, Pavesi A, et al. Lytic efficiency of immunosuppressive drug-resistant armoured T cells against circulating HBV-related HCC in whole blood. Immunother Adv. 2023;3:ltad015 pubmed publisher
Yang S, Wang Y, Yu F, Cheng R, Zhang Y, Zhou D, et al. Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2. Nat Commun. 2023;14:5186 pubmed publisher
Zhang M, Shi X, Zhao J, Guo W, Zhou J. Recruitment of myeloid‑derived suppressor cells and regulatory T‑cells is associated with the occurrence of acute myocardial infarction. Biomed Rep. 2023;19:55 pubmed publisher
Jaeger H, Davis D, Nair A, Shrestha P, Stream A, Yaparla A, et al. Mechanism and therapeutic implications of pomalidomide-induced immune surface marker upregulation in EBV-positive lymphomas. Sci Rep. 2023;13:11596 pubmed publisher
Selvin T, Berglund M, Lenhammar L, Jarvius M, Nygren P, Frykn xe4 s M, et al. Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death. BMC Cancer. 2023;23:164 pubmed publisher
Liu Y, Xu Q, Deng F, Zheng Z, Luo J, Wang P, et al. HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway. J Exp Clin Cancer Res. 2023;42:38 pubmed publisher
Kong F, Ye Q, Xiong Y. Comprehensive analysis of prognosis and immune function of CD70-CD27 signaling axis in pan-cancer. Funct Integr Genomics. 2023;23:48 pubmed publisher
Chen H, Wen X, Liu S, Sun T, Song H, Wang F, et al. Dissecting Heterogeneity Reveals a Unique BAMBIhigh MFGE8high Subpopulation of Human UC-MSCs. Adv Sci (Weinh). 2022;10:e2202510 pubmed publisher
Chan K, Gomez J, Cardinez C, Kumari N, Sparbier C, Lam E, et al. Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses. Cancer Cell. 2022;40:1190-1206.e9 pubmed publisher
Rode A, Buus T, Mraz V, Al Jaberi F, Lopez D, Ford S, et al. Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor. Cells. 2022;11: pubmed publisher
Banerjee A, Li D, Guo Y, Mei Z, Lau C, Chen K, et al. A reengineered common chain cytokine augments CD8+ T cell-dependent immunotherapy. JCI Insight. 2022;7: pubmed publisher
Jensen L, Hoh T, Williamson D, Griffi xe9 J, Sage D, Rubin Delanchy P, et al. Correction of multiple-blinking artifacts in photoactivated localization microscopy. Nat Methods. 2022;19:594-602 pubmed publisher
Saveljeva S, Sewell G, Ramshorn K, Cader M, West J, Clare S, et al. A purine metabolic checkpoint that prevents autoimmunity and autoinflammation. Cell Metab. 2022;34:106-124.e10 pubmed publisher
Siegemund M, Oak P, Hansbauer E, Allersdorfer A, Utschick K, Winter A, et al. Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains. Front Pharmacol. 2021;12:759337 pubmed publisher
Geuijen C, Tacken P, Wang L, Klooster R, Van Loo P, Zhou J, et al. A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade. Nat Commun. 2021;12:4445 pubmed publisher
Puertas M, Bayón Gil Á, Garcia Guerrero M, Salgado M, Urrea V, Morón López S, et al. VIP-SPOT: an Innovative Assay To Quantify the Productive HIV-1 Reservoir in the Monitoring of Cure Strategies. MBio. 2021;12:e0056021 pubmed publisher
Xun X, Zhang C, Wang S, Hu S, Xiang X, Cheng Q, et al. Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization. Am J Transl Res. 2021;13:4360-4375 pubmed
Szanto C, Cornel A, Tamminga S, Delemarre E, de Koning C, van den Beemt D, et al. Immune Monitoring during Therapy Reveals Activitory and Regulatory Immune Responses in High-Risk Neuroblastoma. Cancers (Basel). 2021;13: pubmed publisher
Feldman T, Bercovich A, Moskovitz Y, Chapal Ilani N, Mitchell A, Medeiros J, et al. Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining. Nat Commun. 2021;12:2455 pubmed publisher
Rubio Perez C, Planas Rigol E, Trincado J, Bonfill Teixidor E, Arias A, Marchese D, et al. Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment. Nat Commun. 2021;12:1503 pubmed publisher
Zehravi M, Wahid M, Ashraf J. Episomal reprogramming of Duchenne muscular dystrophy patients derived CD3+ T cells towards induced pluripotent stem cells. Pak J Med Sci. 2021;37:432-438 pubmed publisher
Bost P, De Sanctis F, Cane S, Ugel S, Donadello K, Castellucci M, et al. Deciphering the state of immune silence in fatal COVID-19 patients. Nat Commun. 2021;12:1428 pubmed publisher
Podojil J, Ifergan I, Chiang M, Meeks J, Miller S. Methodology for in vitro Assessment of Human T Cell Activation and Blockade. Bio Protoc. 2020;10:e3644 pubmed publisher
Li H, Kuang X, Liang L, Ye Y, Zhang Y, Li J, et al. The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1. Adv Sci (Weinh). 2021;8:2001596 pubmed publisher
Liu B, Xie Y, Mei X, Sun Y, Shi W, Wu Z. Reciprocal regulation of interleukin-17A and interleukin-22 secretion through aryl hydrocarbon receptor activation in CD4+ T cells of patients with vitiligo. Exp Ther Med. 2021;21:158 pubmed publisher
Lund M, Howard C, Thurecht K, Campbell D, Mahler S, Walsh B. A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells. BMC Cancer. 2020;20:1214 pubmed publisher
Wang T, Zhou Q, Shang Y. Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma. J Innate Immun. 2021;13:38-48 pubmed publisher
Renavikar P, Sinha S, Brate A, Borcherding N, Crawford M, Steward Tharp S, et al. IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation. Front Immunol. 2020;11:568630 pubmed publisher
Su Y, Chen D, Yuan D, Lausted C, Choi J, Dai C, et al. Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19. Cell. 2020;183:1479-1495.e20 pubmed publisher
Ferretti A, Kula T, Wang Y, Nguyen D, Weinheimer A, Dunlap G, et al. Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein. Immunity. 2020;53:1095-1107.e3 pubmed publisher
Yang J, Zhang J, Lu R, Tan Y, Du G, Zhou G. T cell-derived exosomes induced macrophage inflammatory protein-1α/β drive the trafficking of CD8+ T cells in oral lichen planus. J Cell Mol Med. 2020;24:14086-14098 pubmed publisher
Biemann R, Roomp K, Noor F, Krishnan S, Li Z, Shahzad K, et al. Gene expression profile of CD14+ blood monocytes following lifestyle-induced weight loss in individuals with metabolic syndrome. Sci Rep. 2020;10:17855 pubmed publisher
Lee J, Sheen J, Lim O, Lee Y, Ryu J, Shin D, et al. Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy. Sci Rep. 2020;10:17753 pubmed publisher
Ye Y, Kuang X, Xie Z, Liang L, Zhang Z, Zhang Y, et al. Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1. Genome Med. 2020;12:83 pubmed publisher
Sadik A, Somarribas Patterson L, Oztürk S, Mohapatra S, Panitz V, Secker P, et al. IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. Cell. 2020;182:1252-1270.e34 pubmed publisher
Kuehn H, Bernasconi A, Niemela J, Almejún M, Gallego W, Goel S, et al. A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency. J Clin Immunol. 2020;40:1093-1101 pubmed publisher
Boshuizen J, Vredevoogd D, Krijgsman O, Ligtenberg M, Blankenstein S, de Bruijn B, et al. Reversal of pre-existing NGFR-driven tumor and immune therapy resistance. Nat Commun. 2020;11:3946 pubmed publisher
Crawford M, Sinha S, Renavikar P, Borcherding N, Karandikar N. CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression. Proc Natl Acad Sci U S A. 2020;117:19408-19414 pubmed publisher
Ferrara M, Chialli G, Ferreira L, Ruggieri E, Careccia G, Preti A, et al. Oxidation of HMGB1 Is a Dynamically Regulated Process in Physiological and Pathological Conditions. Front Immunol. 2020;11:1122 pubmed publisher
Sahin M, Sahin E. Prostaglandin E2 Reverses the Effects of DNA Methyltransferase Inhibitor and TGFB1 on the Conversion of Naive T Cells to iTregs. Transfus Med Hemother. 2020;47:244-253 pubmed publisher
Wragg K, Tan H, Kristensen A, Nguyen Robertson C, Kelleher A, Parsons M, et al. High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile. Cell Rep. 2020;31:107773 pubmed publisher
Rollins M, Spartz E, Stromnes I. T Cell Receptor Engineered Lymphocytes for Cancer Therapy. Curr Protoc Immunol. 2020;129:e97 pubmed publisher
Hu J, Lei B, Wen D, Ma B, Zhang T, Lu Z, et al. IL-2 enhanced MHC class I expression in papillary thyroid cancer with Hashimoto's thyroiditis overcomes immune escape in vitro. J Cancer. 2020;11:4250-4260 pubmed publisher
Lu Z, Hu J, Liu W, Wen D, Wei W, Wang Y, et al. IL-10 Restores MHC Class I Expression and Interferes With Immunity in Papillary Thyroid Cancer With Hashimoto Thyroiditis. Endocrinology. 2020;161: pubmed publisher
Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed publisher
Ma Y, Yang Q, Fan M, Zhang L, Gu Y, Jia W, et al. Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation. Cell Prolif. 2020;53:e12802 pubmed publisher
Salazar Y, Zheng X, Brunn D, Raifer H, Picard F, Zhang Y, et al. Microenvironmental Th9- and Th17- lymphocytes induce metastatic spreading in lung cancer. J Clin Invest. 2020;: pubmed publisher
Ko J, Kim H, Jeong H, Lee H, Oh J. Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis. Cell Rep. 2020;30:3806-3820.e6 pubmed publisher
Li W, Aryal M, Shu S, Smithgall T. HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane. J Biol Chem. 2020;295:5163-5174 pubmed publisher
Chang Z, Hou A, Chen Y. Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands. Nat Protoc. 2020;15:1507-1524 pubmed publisher
Janssen A, Villacorta Hidalgo J, Beringer D, van Dooremalen S, Fernando F, van Diest E, et al. γδ T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity. Cancer Immunol Res. 2020;8:530-543 pubmed publisher
Kwon M, Kim C, Lee H, Cho H, Kim Y, Lee E, et al. PD-1 Blockade Reinvigorates Bone Marrow CD8+ T Cells from Patients with Multiple Myeloma in the Presence of TGFβ Inhibitors. Clin Cancer Res. 2020;26:1644-1655 pubmed publisher
Verdura S, Cuyàs E, Cortada E, Brunet J, Lopez Bonet E, Martin Castillo B, et al. Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity. Aging (Albany NY). 2020;12:8-34 pubmed publisher
Wang W, Cohen J, Wallrapp A, Trieu K, Barrios J, Shao F, et al. Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung. Immunity. 2019;51:1102-1118.e7 pubmed publisher
Levring T, Kongsbak Wismann M, Rode A, Al Jaberi F, Lopez D, Met O, et al. Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells. Sci Rep. 2019;9:16725 pubmed publisher
Davies S, Reynolds G, Wilkinson A, Li X, Rose R, Leekha M, et al. Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process. Cell Rep. 2019;29:1610-1620.e4 pubmed publisher
Rossatti P, Ziegler L, Schregle R, Betzler V, Ecker M, Rossy J. Cdc42 Couples T Cell Receptor Endocytosis to GRAF1-Mediated Tubular Invaginations of the Plasma Membrane. Cells. 2019;8: pubmed publisher
Burchiel S, Lauer F, Factor Litvak P, Liu X, Santella R, Eunus M, et al. An increase in circulating B cells and B cell activation markers in peripheral blood is associated with cigarette smoking in a male cohort in Bangladesh. Toxicol Appl Pharmacol. 2019;384:114783 pubmed publisher
Esfahani K, Al Aubodah T, Thebault P, Lapointe R, Hudson M, Johnson N, et al. Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation. Nat Commun. 2019;10:4712 pubmed publisher
Tanaskovic O, Verga Falzacappa M, Pelicci P. Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells. PLoS ONE. 2019;14:e0217345 pubmed publisher
Gomez Lopez N, Romero R, Xu Y, Miller D, Arenas Hernandez M, Garcia Flores V, et al. Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth. J Immunol. 2019;203:1793-1807 pubmed publisher
Han L, Hu J, Ma B, Wen D, Zhang T, Lu Z, et al. IL-17A increases MHC class I expression and promotes T cell activation in papillary thyroid cancer patients with coexistent Hashimoto's thyroiditis. Diagn Pathol. 2019;14:52 pubmed publisher
Zhang L, Yu J. Triptolide reverses helper T cell inhibition and down-regulates IFN-γ induced PD-L1 expression in glioma cell lines. J Neurooncol. 2019;143:429-436 pubmed publisher
Oda H, Beck D, Kuehn H, Sampaio Moura N, Hoffmann P, Ibarra M, et al. Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC. Front Immunol. 2019;10:479 pubmed publisher
Ha E, Choi J, Kwon H, Park H, Lah S, Moon K, et al. Endothelial Sox17 promotes allergic airway inflammation. J Allergy Clin Immunol. 2019;: pubmed publisher
Cao Y, Trillo Tinoco J, Sierra R, Anadon C, Dai W, Mohamed E, et al. ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. Nat Commun. 2019;10:1280 pubmed publisher
Atay C, Kwak T, Lavilla Alonso S, Donthireddy L, Richards A, Moberg V, et al. BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells. Clin Cancer Res. 2019;25:2783-2794 pubmed publisher
Davis D, Shrestha P, Aisabor A, Stream A, Galli V, Pise Masison C, et al. Pomalidomide increases immune surface marker expression and immune recognition of oncovirus-infected cells. Oncoimmunology. 2019;8:e1546544 pubmed publisher
Mo X, Tang C, Niu Q, Ma T, Du Y, Fu H. HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers. Cell Chem Biol. 2019;26:331-339.e3 pubmed publisher
Tran H, Herz C, Ruf P, Stetter R, Lamy E. Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes. Front Immunol. 2018;9:2949 pubmed publisher
Bamidele A, Svingen P, Sagstetter M, Sarmento O, González M, Braga Neto M, et al. Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation. Cell Mol Gastroenterol Hepatol. 2019;7:55-71 pubmed publisher
Li Y, Tan S, Zhang C, Chai Y, He M, Zhang C, et al. Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab. Cell Rep. 2018;25:909-920.e4 pubmed publisher
Cao M, Wang C, Chung W, Motabar D, Wang J, Christian E, et al. Characterization and analysis of scFv-IgG bispecific antibody size variants. MAbs. 2018;10:1236-1247 pubmed publisher
Idelson M, Alper R, Obolensky A, Yachimovich Cohen N, Rachmilewitz J, Ejzenberg A, et al. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Stem Cell Reports. 2018;11:681-695 pubmed publisher
Cha J, Yang W, Xia W, Wei Y, Chan L, Lim S, et al. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Mol Cell. 2018;71:606-620.e7 pubmed publisher
Boutboul D, Kuehn H, Van de Wyngaert Z, Niemela J, Callebaut I, Stoddard J, et al. Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency. J Clin Invest. 2018;128:3071-3087 pubmed publisher
Pan H, Liu J, Deng W, Xing J, Li Q, Wang Z. Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy. Int J Nanomedicine. 2018;13:3189-3201 pubmed publisher
Song H, Giorgi E, Ganusov V, Cai F, Athreya G, Yoon H, et al. Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection. Nat Commun. 2018;9:1928 pubmed publisher
Compeer E, Kraus F, Ecker M, Redpath G, Amiezer M, Rother N, et al. A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation. Nat Commun. 2018;9:1597 pubmed publisher
Shi Y, Zhang P, Wang G, Liu X, Sun X, Zhang X, et al. Description of organ-specific phenotype, and functional characteristics of tissue resident lymphocytes from liver transplantation donor and research on immune tolerance mechanism of liver. Oncotarget. 2018;9:15552-15565 pubmed publisher
Holien T, Gederaas O, Darvekar S, Christensen E, Peng Q. Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo. Lasers Surg Med. 2018;50:469-475 pubmed publisher
Carpier J, Zucchetti A, Bataille L, Dogniaux S, Shafaq Zadah M, Bardin S, et al. Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation. J Exp Med. 2018;215:1245-1265 pubmed publisher
Seki A, Rutz S. Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells. J Exp Med. 2018;215:985-997 pubmed publisher
Martin S, Wick D, Nielsen J, Little N, Holt R, Nelson B. A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer. Oncoimmunology. 2017;7:e1371895 pubmed publisher
Shir A, Klein S, Sagiv Barfi I, Geiger T, Zigler M, Langut Y, et al. S101, an inhibitor of proliferating T-cells, rescues mice from superantigen-induced shock. J Infect Dis. 2017;: pubmed publisher
Meng Y, Zhou W, Jin L, Liu L, Chang K, Mei J, et al. RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization. Cell Death Dis. 2017;8:e3105 pubmed publisher
Sawicka A, Babataheri A, Dogniaux S, Barakat A, González Rodríguez D, Hivroz C, et al. Micropipette force probe to quantify single-cell force generation: application to T-cell activation. Mol Biol Cell. 2017;28:3229-3239 pubmed publisher
Hayashi T, Jean M, Huang H, Simpson S, Santoso N, Zhu J. Screening of an FDA-approved compound library identifies levosimendan as a novel anti-HIV-1 agent that inhibits viral transcription. Antiviral Res. 2017;146:76-85 pubmed publisher
Tsai A, Khan A, Worgo C, Wang L, Liang Y, Davila E. A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies. Cancer Immunol Res. 2017;5:790-803 pubmed publisher
Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw A, et al. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017;127:3136-3151 pubmed publisher
Bughani U, Saha A, Kuriakose A, Nair R, Sadashivarao R, Venkataraman R, et al. T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab. PLoS ONE. 2017;12:e0180088 pubmed publisher
Huang H, Liu S, Jean M, Simpson S, Huang H, Merkley M, et al. A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association. Front Microbiol. 2017;8:1035 pubmed publisher
Zheng C, Zheng L, Yoo J, Guo H, Zhang Y, Guo X, et al. Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing. Cell. 2017;169:1342-1356.e16 pubmed publisher
Saitakis M, Dogniaux S, Goudot C, Bufi N, Asnacios S, Maurin M, et al. Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity. elife. 2017;6: pubmed publisher
Hernández Del Pino R, Pellegrini J, Rovetta A, Peña D, Álvarez G, Rolandelli A, et al. Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses. Immunol Cell Biol. 2017;95:716-728 pubmed publisher
Tello Lafoz M, Martínez Martínez G, Rodríguez Rodríguez C, Albar J, Huse M, Gharbi S, et al. Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse. Traffic. 2017;18:491-504 pubmed publisher
Seignez A, Joly A, Chaumonnot K, Hazoume A, Sanka M, Marcion G, et al. Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease. JCI Insight. 2017;2:e90531 pubmed publisher
Datlinger P, Rendeiro A, Schmidl C, Krausgruber T, Traxler P, Klughammer J, et al. Pooled CRISPR screening with single-cell transcriptome readout. Nat Methods. 2017;14:297-301 pubmed publisher
Chen J, Wang Q, Feng X, Zhang Z, Geng L, Xu T, et al. Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria. Stem Cells Int. 2016;2016:4062789 pubmed publisher
Cárcamo Orive I, Hoffman G, Cundiff P, Beckmann N, D Souza S, Knowles J, et al. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity. Cell Stem Cell. 2017;20:518-532.e9 pubmed publisher
Zhu H, Hu F, Sun X, Zhang X, Zhu L, Liu X, et al. CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus. Front Immunol. 2016;7:512 pubmed
Kiniry B, Ganesh A, Critchfield J, Hunt P, Hecht F, Somsouk M, et al. Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. Mucosal Immunol. 2017;10:1008-1020 pubmed publisher
Son C, Lee H, Koh E, Shin D, Bae J, Yang K, et al. Combination treatment with decitabine and ionizing radiation enhances tumor cells susceptibility of T cells. Sci Rep. 2016;6:32470 pubmed publisher
Guillou L, Babataheri A, Saitakis M, Bohineust A, Dogniaux S, Hivroz C, et al. T-lymphocyte passive deformation is controlled by unfolding of membrane surface reservoirs. Mol Biol Cell. 2016;27:3574-3582 pubmed
Du S, Li Z, Chen C, Tan W, Chi Z, Kwang T, et al. Co-Expansion of Cytokine-Induced Killer Cells and V?9V?2 T Cells for CAR T-Cell Therapy. PLoS ONE. 2016;11:e0161820 pubmed publisher
Pageon S, Nicovich P, Mollazade M, Tabarin T, Gaus K. Clus-DoC: a combined cluster detection and colocalization analysis for single-molecule localization microscopy data. Mol Biol Cell. 2016;27:3627-3636 pubmed
Pageon S, Tabarin T, Yamamoto Y, Ma Y, Nicovich P, Bridgeman J, et al. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proc Natl Acad Sci U S A. 2016;113:E5454-63 pubmed publisher
Clever D, Roychoudhuri R, Constantinides M, Askenase M, Sukumar M, Klebanoff C, et al. Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche. Cell. 2016;166:1117-1131.e14 pubmed publisher
Starling S, Jolly C. LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse. J Virol. 2016;90:9841-9854 pubmed publisher
You Y, Tan J, Dai H, Chen H, Xu X, Yang A, et al. MiRNA-22 inhibits oncogene galectin-1 in hepatocellular carcinoma. Oncotarget. 2016;7:57099-57116 pubmed publisher
Momose F, Seo N, Akahori Y, Sawada S, Harada N, Ogura T, et al. Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types. PLoS ONE. 2016;11:e0154134 pubmed publisher
Siddiqui I, Erreni M, van Brakel M, Debets R, Allavena P. Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient. J Immunother Cancer. 2016;4:21 pubmed publisher
Jones R, Mueller S, O Connor R, Rimpel K, Sloan D, Karel D, et al. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog. 2016;12:e1005545 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscience
Catalog # :
16-0037-025
Quantity :
25 mg
Price :
US 9350.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 0.25 ug/test, Functional Assay: Assay-Dependent
Species :
Human
Clone :
OKT3
Isotype :
IgG2a, kappa
Storage :
4 C
Description :
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test, Functional Assay: Assay-Dependent
Aliases :
4930549J05Rik; A430104F18Rik; AI504783; antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; CD3; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon; CD3 epsilon chain; CD3 epsilon subunit; CD3 epsilon subunit precursor; CD3 gamma-chain; CD3 glycoprotein; CD3 glycoprotein precursor; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma; CD3 molecule, gamma polypeptide; CD3 protein; CD3 TCR complex; CD3 type I transmembrane glycoprotein; CD3 type I transmembrane glycoprotein precursor; CD3 zeta chain; Cd3d; CD3D antigen delta; CD3D antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; Cd3e; CD3E antigen, epsilon polypeptide; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3-epsilon; Cd3-eta; Cd3g; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; Cd3h; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; Ctg3; Ctg-3; FLJ18683; IMD17; IMD18; IMD19; IMD25; Leu-4; OKT3, delta chain; T cell antigen receptor complex epsilon subunit of T3; T3/TCR complex; T3d; T3e; T3g; T3Z; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 epsilon chain; T-cell receptor CD3 epsilon subunit; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T-cell surface protein; TcR CD3 delta-chain; TcR CD3 gamma-chain; TCR zeta chain; TCR zeta chain subunit; TCRE; Tcrk; TCRZ; TCRzeta; TiT3 complex; type I transmembrane protein; T-cell surface molecule CD3
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA