product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD3e Monoclonal Antibody (145-2C11), Functional Grade, eBioscience
catalog :
16-0031-38
quantity :
5 mg
price :
US 2860.00
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
145-2C11
reactivity :
mouse
application :
western blot, immunohistochemistry, flow cytometry, blocking or activating experiments
more info or order :
citations: 298
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; mouse; 1 ug/ml; loading ...; fig 1d
Liu M, Wu C, Luo S, Hua Q, Chen H, Weng Y, et al. PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen. J Exp Med. 2022;219: pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3, 4a
Keller E, Dvorina N, Jørgensen T. Spontaneous CD4+ T Cell Activation and Differentiation in Lupus-Prone B6.Nba2 Mice Is IFNAR-Independent. Int J Mol Sci. 2022;23: pubmed publisher
  • flow cytometry; mouse; fig 1b
Almishri W, Swain L, D Mello C, Le T, Urbanski S, Nguyen H. ADAM Metalloproteinase Domain 17 Regulates Cholestasis-Associated Liver Injury and Sickness Behavior Development in Mice. Front Immunol. 2021;12:779119 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Hoffman R, Huang S, Chalasani G, Vallejo A. Disparate Recruitment and Retention of Plasmacytoid Dendritic Cells to The Small Intestinal Mucosa between Young and Aged Mice. Aging Dis. 2021;12:1183-1196 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s5
Lacy M, Burger C, Shami A, Ahmadsei M, Winkels H, Nitz K, et al. Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nat Commun. 2021;12:3754 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1d, 3f
Oikonomou N, Schuijs M, Chatzigiagkos A, Androulidaki A, Aidinis V, Hammad H, et al. Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation. Mucosal Immunol. 2021;14:1160-1171 pubmed publisher
  • flow cytometry; mouse; 1:1000; loading ...; fig 2i
Roca C, Burton O, Gergelits V, Prezzemolo T, Whyte C, Halpert R, et al. AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data. Nat Commun. 2021;12:2890 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Kalinina A, Khromykh L, Kazansky D, Deykin A, Silaeva Y. Suppression of the Immune Response by Syngeneic Splenocytes Adoptively Transferred to Sublethally Irradiated Mice. Acta Naturae. 2021;13:116-126 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3
Flamini S, Sergeev P, Viana de Barros Z, Mello T, Biagioli M, Paglialunga M, et al. Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment. Cell Death Dis. 2021;12:421 pubmed publisher
  • flow cytometry; mouse; loading ...
Fallon E, Chung C, Heffernan D, Chen Y, De Paepe M, Ayala A. Survival and Pulmonary Injury After Neonatal Sepsis: PD1/PDL1's Contributions to Mouse and Human Immunopathology. Front Immunol. 2021;12:634529 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3f
Yuan J, Cai T, Zheng X, Ren Y, Qi J, Lu X, et al. Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling. Protein Cell. 2021;12:240-260 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 4b
Aslam M, Alemdehy M, Kwesi Maliepaard E, Muhaimin F, Caganova M, Pardieck I, et al. Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation. EMBO Rep. 2021;22:e51184 pubmed publisher
  • flow cytometry; mouse
Webb L, Fra Bido S, Innocentin S, Matheson L, Attaf N, Bignon A, et al. Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ. Aging Cell. 2021;20:e13295 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...
Jensen I, Jensen S, Sjaastad F, Gibson Corley K, Dileepan T, Griffith T, et al. Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...
Gao L, Li B, Wang J, Shen D, Yang M, Sun R, et al. Activation of Liver X Receptor α Sensitizes Mice to T-Cell Mediated Hepatitis. Hepatol Commun. 2020;4:1664-1679 pubmed publisher
  • flow cytometry; mouse; loading ...
Myers D, Abram C, Wildes D, Belwafa A, Welsh A, Schulze C, et al. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020;11:576310 pubmed publisher
  • flow cytometry; mouse
Florian M, Leins H, Gobs M, Han Y, Marka G, Soller K, et al. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging Cell. 2020;:e13208 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2a
  • immunohistochemistry; mouse
Pasciuto E, Burton O, Roca C, Lagou V, Rajan W, Theys T, et al. Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell. 2020;182:625-640.e24 pubmed publisher
  • immunohistochemistry; mouse; fig 4a
Lubos N, van der Gaag S, Gerçek M, Kant S, Leube R, Krusche C. Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy. Basic Res Cardiol. 2020;115:42 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1
Tizian C, Lahmann A, Hölsken O, Cosovanu C, Kofoed Branzk M, Heinrich F, et al. c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig e9g
Hang S, Paik D, Yao L, Kim E, Jamma T, Lu J, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019;576:143-148 pubmed publisher
  • flow cytometry; mouse; 1:50; loading ...; fig e1a
Vagnozzi R, Maillet M, Sargent M, Khalil H, Johansen A, Schwanekamp J, et al. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020;577:405-409 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Kumar P, Rajasekaran K, Nanbakhsh A, Gorski J, Thakar M, Malarkannan S. IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection. Sci Rep. 2019;9:4984 pubmed publisher
Zuo B, Li T, Liu X, Wang S, Cheng J, Liu X, et al. Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer. Clin Transl Oncol. 2023;25:3188-3202 pubmed publisher
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Hajnik R, Plante J, Liang Y, Alameh M, Tang J, Bonam S, et al. Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models. Sci Transl Med. 2022;14:eabq1945 pubmed publisher
Dunlock V, Arp A, Singh S, Charrin S, Nguyen V, Jansen E, et al. Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function. Cell Rep. 2022;39:111006 pubmed publisher
Zhang L, Zhang K, Zhang J, Zhu J, Xi Q, Wang H, et al. Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization. Nat Commun. 2021;12:4300 pubmed publisher
Amici S, Osman W, Guerau de Arellano M. PRMT5 Promotes Cyclin E1 and Cell Cycle Progression in CD4 Th1 Cells and Correlates With EAE Severity. Front Immunol. 2021;12:695947 pubmed publisher
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Carnell G, Ciazynska K, Wells D, Xiong X, Aguinam E, McLaughlin S, et al. SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses. J Virol. 2021;95:e0020321 pubmed publisher
Ergang P, Vagnerova K, Hermanova P, Vodička M, Jágr M, Srůtková D, et al. The Gut Microbiota Affects Corticosterone Production in the Murine Small Intestine. Int J Mol Sci. 2021;22: pubmed publisher
Pan X, Yao K, Yang Y, Ge Q, Zhang R, Gao P, et al. Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ. Front Cell Dev Biol. 2021;9:637424 pubmed publisher
Fang W, Zhou T, Shi H, Yao M, Zhang D, Qian H, et al. Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion. J Exp Clin Cancer Res. 2021;40:4 pubmed publisher
De Martino M, Daviaud C, Diamond J, Kraynak J, Alard A, Formenti S, et al. Activin A Promotes Regulatory T-cell-Mediated Immunosuppression in Irradiated Breast Cancer. Cancer Immunol Res. 2021;9:89-102 pubmed publisher
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Chen Q, Xu L, Liang C, Wang C, Peng R, Liu Z. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nat Commun. 2016;7:13193 pubmed publisher
Bagchi S, Li S, Wang C. CD1b-autoreactive T cells recognize phospholipid antigens and contribute to antitumor immunity against a CD1b+ T cell lymphoma. Oncoimmunology. 2016;5:e1213932 pubmed
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product information
Product Type :
Antibody
Product Name :
CD3e Monoclonal Antibody (145-2C11), Functional Grade, eBioscience
Catalog # :
16-0031-38
Quantity :
5 mg
Price :
US 2860.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test, Functional Assay: Assay-Dependent
Species :
Mouse
Clone :
145-2C11
Isotype :
IgG
Storage :
4° C
Description :
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test, Functional Assay: Assay-Dependent
Aliases :
4930549J05Rik; A430104F18Rik; AI504783; antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; CD3; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon; CD3 epsilon chain; CD3 epsilon subunit; CD3 epsilon subunit precursor; CD3 gamma-chain; CD3 glycoprotein; CD3 glycoprotein precursor; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma; CD3 molecule, gamma polypeptide; CD3 protein; CD3 TCR complex; CD3 type I transmembrane glycoprotein; CD3 type I transmembrane glycoprotein precursor; CD3 zeta chain; Cd3d; CD3D antigen delta; CD3D antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; Cd3e; CD3E antigen, epsilon polypeptide; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3-epsilon; Cd3-eta; Cd3g; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; Cd3h; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; Ctg3; Ctg-3; FLJ18683; IMD17; IMD18; IMD19; IMD25; Leu-4; OKT3, delta chain; T cell antigen receptor complex epsilon subunit of T3; T3/TCR complex; T3d; T3e; T3g; T3Z; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 epsilon chain; T-cell receptor CD3 epsilon subunit; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T-cell surface protein; TcR CD3 delta-chain; TcR CD3 gamma-chain; TCR zeta chain; TCR zeta chain subunit; TCRE; Tcrk; TCRZ; TCRzeta; TiT3 complex; type I transmembrane protein; T-cell surface molecule CD3
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA