This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
HELIOS Monoclonal Antibody (22F6), PE-Cyanine5, eBioscience
catalog :
15-9883-42
quantity :
100 Tests
price :
US 469.00
clonality :
monoclonal
host :
hamsters
conjugate :
PE-Cy5
clone name :
22F6

The same clone is also sold as:
reactivity :
human, mouse, dogs
application :
flow cytometry
citations: 12
Reference
Thomas R, Pahl M, Wang L, Grant S, Hancock W, Wells A. Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function. elife. 2024;12: pubmed publisher
Wang Y, Guo A, Zou Y, Mu W, Zhang S, Shi Z, et al. Interaction between tissue-dwelling helminth and the gut microbiota drives mucosal immunoregulation. NPJ Biofilms Microbiomes. 2023;9:43 pubmed publisher
Lombard Vadnais F, Chabot Roy G, Zahn A, Rodriguez Torres S, Di Noia J, Melichar H, et al. Activation-induced cytidine deaminase expression by thymic B cells promotes T-cell tolerance and limits autoimmunity. iScience. 2023;26:105852 pubmed publisher
Zhang Z, Xie K, Luo R, Zhang D, He Z, Li K, et al. Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway. Inflammopharmacology. 2023;31:423-438 pubmed publisher
Piekarska K, Urban Wójciuk Z, Kurkowiak M, Pelikant Małecka I, Schumacher A, Sakowska J, et al. Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity. Nat Commun. 2022;13:856 pubmed publisher
Ramos Ram xed rez P, Malmh xe4 ll C, Tliba O, R xe5 dinger M, Bossios A. Adiponectin/AdipoR1 Axis Promotes IL-10 Release by Human Regulatory T Cells. Front Immunol. 2021;12:677550 pubmed publisher
Zhang Y, Zhang J, Shi Y, Shen M, Lv H, Chen S, et al. Differences in Maturation Status and Immune Phenotypes of Circulating Helios+ and Helios- Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals. Front Immunol. 2021;12:628504 pubmed publisher
Harb H, Benamar M, Lai P, Contini P, Griffith J, Crestani E, et al. Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. Immunity. 2021;54:1186-1199.e7 pubmed publisher
Wang C, Xie K, Li K, Lin S, Xu F. Potential therapeutic effects of interleukin-35 on the differentiation of naïve T cells into Helios+Foxp3+ Tregs in clinical and experimental acute respiratory distress syndrome. Mol Immunol. 2021;132:236-249 pubmed publisher
Watanabe M, Lu Y, Breen M, Hodes R. B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms. Nat Commun. 2020;11:6264 pubmed publisher
Harb H, Stephen Victor E, Crestani E, Benamar M, Massoud A, Cui Y, et al. A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2020;21:1359-1370 pubmed publisher
van de Wouw M, Walsh A, Crispie F, van Leuven L, Lyte J, Boehme M, et al. Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse. Microbiome. 2020;8:67 pubmed publisher
product information
Product Type :
Antibody
Product Name :
HELIOS Monoclonal Antibody (22F6), PE-Cyanine5, eBioscience
Catalog # :
15-9883-42
Quantity :
100 Tests
Price :
US 469.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Canine, Human, Mouse
Applications :
Flow Cytometry: 5 uL (0.06 ug)/test
Species :
Canine, Human, Mouse
Clone :
22F6
Isotype :
IgG
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.06 ug)/test
Aliases :
A730095J18Rik; ANF1A2; Helios; IKAROS family zinc finger 2; IKAROS family zinc finger 2 (Helios); ikaros family zinc finger protein 2; Ikzf2; Zfpn1a2; zinc finger DNA binding protein Helios; zinc finger protein Helios; zinc finger protein, subfamily 1A, 2 (Helios); ZNF1A2; Znfn1a2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA