CD95 (APO-1/Fas) Monoclonal Antibody (DX2), PE-Cyanine5, eBioscience | Invitrogen 15-0959-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD95 (APO-1/Fas) Monoclonal Antibody (DX2), PE-Cyanine5, eBioscience

catalog :

15-0959-42

quantity :

100 Tests

price :

US 345.00

clonality :

monoclonal

host :

mouse

conjugate :

PE-Cy5

clone name :

DX2

The same clone is also sold as:

BD Biosciences: 558814, 561977, 555671, 556640, 561978, 555673, 561636, 556641, 561632, 555674, 561635, 340481, 561976, 559773, 561633, 555672, 562395, 555670, 561975, 340479, 340480
R&D Systems: MAB142
OriGene: AM08165FC-N, AM08165RP-N, AM08165AC-N, AM08165LE-N, AM08165PU-N, AM08165BT-N
BioLegend: 305646, 305667, 305624, 305655, 305645, 305610, 305634, 305666, 260384, 305644, 305631, 987102, 305668, 305633, 305627, 305662, 305661, 305653, 305656, 305671, 305657, 305672, 305643, 305649, 305623, 305615, 305665, 305605, 305670, 305630, 305663, 305611, 305651, 305648, 305658, 305604, 305608, 305639, 305602, 305640, 305674, 305607, 305659, 305618, 305675, 305621, 305636, 305635, 305622, 305669, 305637, 305664, 305619, 305628, 305641, 305647, 305612, 305642, 305638, 305606, 305676, 305616, 305629, 305673

reactivity :

human, dogs

application :

flow cytometry

citations: 15

Reference
Rahman M, Bissa M, Silva de Castro I, Helmold Hait S, Stamos J, Bhuyan F, et al. Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques. Nat Microbiol. 2023;8:905-918 pubmed publisher
Xu Q, Milanez Almeida P, Martins A, Radtke A, Hoehn K, Oguz C, et al. Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children. Nat Immunol. 2023;24:186-199 pubmed publisher
Kreutmair S, Unger S, Núñez N, Ingelfinger F, Alberti C, De Feo D, et al. Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia. Immunity. 2021;54:1578-1593.e5 pubmed publisher
Yu C, Littleton S, Giroux N, Mathew R, Ding S, Kalnitsky J, et al. Mucosal-associated invariant T cell responses differ by sex in COVID-19. Med (N Y). 2021;2:755-772.e5 pubmed publisher
Li X, Zhang B, Wang H, Zhao X, Zhang Z, Ding G, et al. Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells. J Int Med Res. 2020;48:300060520930853 pubmed publisher
Vinton C, Magaziner S, Dowd K, Robertson S, Amaro Carambot E, Karmele E, et al. Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance. MBio. 2019;10: pubmed publisher
Zhang M, Wang J, Jia L, Huang J, He C, Hu F, et al. Transmembrane TNF-? promotes activation-induced cell death by forward and reverse signaling. Oncotarget. 2017;8:63799-63812 pubmed publisher
Kong F, Feng B, Zhang H, Rao H, Wang J, Cong X, et al. Abnormal phenotypic features of IgM+B cell subsets in patients with chronic hepatitis C virus infection. Exp Ther Med. 2017;14:1846-1852 pubmed publisher
Mou H, Moore J, Malonia S, Li Y, Ozata D, Hough S, et al. Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2017;114:3648-3653 pubmed publisher
Tuero I, Mohanram V, Musich T, Miller L, Vargas Inchaustegui D, Demberg T, et al. Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIVmac251 Rectal Challenge. PLoS Pathog. 2015;11:e1005101 pubmed publisher
Shi L, Wang H, Wang F, Feng M, Wang M, Guan W. Effects of gastrokineâ€‘2 expression on gastric cancer cell apoptosis by activation of extrinsic apoptotic pathways. Mol Med Rep. 2014;10:2898-904 pubmed publisher
Russier M, Reynard S, Carnec X, Baize S. The exonuclease domain of Lassa virus nucleoprotein is involved in antigen-presenting-cell-mediated NK cell responses. J Virol. 2014;88:13811-20 pubmed publisher
Chahroudi A, Cartwright E, Lee S, Mavigner M, Carnathan D, Lawson B, et al. Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques. PLoS Pathog. 2014;10:e1003958 pubmed publisher
Dompe N, Rivers C, Li L, Cordes S, Schwickart M, Punnoose E, et al. A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2011;108:E943-51 pubmed publisher
Orbach A, Rachmilewitz J, Shani N, Isenberg Y, Parnas M, Huang J, et al. CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling. Am J Pathol. 2010;177:3159-68 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD95 (APO-1/Fas) Monoclonal Antibody (DX2), PE-Cyanine5, eBioscience

Catalog # :

15-0959-42

Quantity :

100 Tests

Price :

US 345.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Canine, Human

Applications :

Flow Cytometry: 5 uL (0.5 ug)/test

Species :

Canine, Human

Clone :

DX2

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.5 ug)/test

Aliases :

AI196731; ALPS1A; APO1; APO-1; Apo1 antigen; Apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; FAS; Fas (TNF receptor superfamily member 6); Fas (TNF receptor superfamily member); Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; Fas antigen (ATP1); Fas cell surface death receptor; Fas receptor; FAS1; FASLG receptor; FASTM; lpr; lymphoproliferation; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; TNFR6; Tnfrsf6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 26; Tumor necrosis factor receptor superfamily, member 6