LAT Monoclonal Antibody (LAT.10-17 (10-17)), eBioscience | Invitrogen 14-9967-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LAT Monoclonal Antibody (LAT.10-17 (10-17)), eBioscience

catalog :

14-9967-82

quantity :

100 ug

price :

US 440.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

LAT.10-17 (10-17)

reactivity :

human

application :

western blot, immunoprecipitation

citations: 4

Reference
Dine E, Reed E, Toettcher J. Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Cell Rep. 2021;35:109280 pubmed publisher
Burbach B, Medeiros R, Mueller K, Shimizu Y. T-cell receptor signaling to integrins. Immunol Rev. 2007;218:65-81 pubmed
Koonpaew S, Shen S, Flowers L, Zhang W. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med. 2006;203:119-29 pubmed
Malissen B, Aguado E, Malissen M. Role of the LAT adaptor in T-cell development and Th2 differentiation. Adv Immunol. 2005;87:1-25 pubmed

product information

Product Type :

Antibody

Product Name :

LAT Monoclonal Antibody (LAT.10-17 (10-17)), eBioscience

Catalog # :

14-9967-82

Quantity :

100 ug

Price :

US 440.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunoprecipitation: 5 ug/mL, Western Blot: 1.5-5 ug/mL

Species :

Human

Clone :

LAT.10-17 (10-17)

Isotype :

IgG1, kappa

Storage :

4 C

Description :

LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: 5 ug/mL, Western Blot: 1.5-5 ug/mL

Aliases :

36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; Lat; LAT1; linker for activation of T cells; linker for activation of T cells, transmembrane adaptor; linker for activation of T-cells; linker for activation of T-cells family member 1; linker protein; p36-38; pp36