This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
FOXJ1 Monoclonal Antibody (2A5), eBioscience™
catalog :
14-9965-95
quantity :
10 mg
price :
US 3000.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2A5
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 39
Reference
Chu Q, Yao C, Qi X, Stripp B, Tang N. STK11 is required for the normal program of ciliated cell differentiation in airways. Cell Discov. 2019;5:36 pubmed publisher
Stupnikov M, Yang Y, Mori M, LU J, Cardoso W. Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation. elife. 2019;8: pubmed publisher
Fiege J, Stone I, Dumm R, Waring B, Fife B, Agudo J, et al. Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance. PLoS Pathog. 2019;15:e1008077 pubmed publisher
Fujino N, Brand O, Morgan D, Fujimori T, Grabiec A, Jagger C, et al. Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases. J Exp Med. 2019;216:2184-2201 pubmed publisher
Ortiz Álvarez G, Daclin M, Shihavuddin A, Lansade P, Fortoul A, Faucourt M, et al. Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members. Neuron. 2019;102:159-172.e7 pubmed publisher
Dumm R, Fiege J, Waring B, Kuo C, Langlois R, Heaton N. Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function. Nat Commun. 2019;10:779 pubmed publisher
Revinski D, Zaragosi L, Boutin C, Ruiz García S, Deprez M, Thomé V, et al. CDC20B is required for deuterosome-mediated centriole production in multiciliated cells. Nat Commun. 2018;9:4668 pubmed publisher
Levardon H, Yonker L, Hurley B, Mou H. Expansion of Airway Basal Cells and Generation of Polarized Epithelium. Bio Protoc. 2018;8: pubmed publisher
Tata P, Chow R, Saladi S, Tata A, Konkimalla A, Bara A, et al. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell. 2018;44:679-693.e5 pubmed publisher
Hedström U, Hallgren O, Öberg L, DeMicco A, Vaarala O, Westergren Thorsson G, et al. Bronchial extracellular matrix from COPD patients induces altered gene expression in repopulated primary human bronchial epithelial cells. Sci Rep. 2018;8:3502 pubmed publisher
Muniz Talavera H, Schmidt J. The mouse Jhy gene regulates ependymal cell differentiation and ciliogenesis. PLoS ONE. 2017;12:e0184957 pubmed publisher
Otto T, Candido S, Pilarz M, Sicinska E, Bronson R, Bowden M, et al. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017;114:10660-10665 pubmed publisher
Van Dyken S, Liang H, Naikawadi R, Woodruff P, Wolters P, Erle D, et al. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 2017;169:497-509.e13 pubmed publisher
Liu K, Fan J, Wu J. Forkhead Box Protein J1 (FOXJ1) is Overexpressed in Colorectal Cancer and Promotes Nuclear Translocation of β-Catenin in SW620 Cells. Med Sci Monit. 2017;23:856-866 pubmed
Ray S, Chiba N, Yao C, Guan X, McConnell A, Brockway B, et al. Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection. Stem Cell Reports. 2016;7:817-825 pubmed publisher
Dye B, Dedhia P, Miller A, Nagy M, White E, Shea L, et al. A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids. elife. 2016;5: pubmed publisher
Mulay A, Akram K, Williams D, Armes H, Russell C, Hood D, et al. An in vitro model of murine middle ear epithelium. Dis Model Mech. 2016;9:1405-1417 pubmed
Mou H, Vinarsky V, Tata P, Brazauskas K, Choi S, Crooke A, et al. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. 2016;19:217-231 pubmed publisher
Balasooriya G, Johnson J, Basson M, Rawlins E. An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. Dev Cell. 2016;37:85-97 pubmed publisher
Nagao M, Ogata T, Sawada Y, Gotoh Y. Zbtb20 promotes astrocytogenesis during neocortical development. Nat Commun. 2016;7:11102 pubmed publisher
Li L, Grausam K, Wang J, Lun M, Ohli J, Lidov H, et al. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol. 2016;18:418-30 pubmed publisher
Terré B, Piergiovanni G, Segura Bayona S, Gil Gómez G, Youssef S, Attolini C, et al. GEMC1 is a critical regulator of multiciliated cell differentiation. EMBO J. 2016;35:942-60 pubmed publisher
Gao X, Bali A, Randell S, Hogan B. GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. J Cell Biol. 2015;211:669-82 pubmed publisher
Ohata S, Herranz Pérez V, Nakatani J, Boletta A, García Verdugo J, Álvarez Buylla A. Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium. J Neurosci. 2015;35:11153-68 pubmed publisher
Pardo Saganta A, Tata P, Law B, Saez B, Chow R, Prabhu M, et al. Parent stem cells can serve as niches for their daughter cells. Nature. 2015;523:597-601 pubmed publisher
Yu T, Chen X, Zhang W, Liu J, Avdiushko R, Napier D, et al. KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer. Cell Death Differ. 2016;23:207-15 pubmed publisher
Holik A, Filby C, Pasquet J, Viitaniemi K, Ciciulla J, Sutherland K, et al. The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression. Respir Res. 2015;16:67 pubmed publisher
Cuevas E, Rybak Wolf A, Rohde A, Nguyen D, Wulczyn F. Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain. Front Cell Dev Biol. 2015;3:20 pubmed publisher
Galvis L, Holik A, Short K, Pasquet J, Lun A, Blewitt M, et al. Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung. Development. 2015;142:1458-69 pubmed publisher
Pardo Saganta A, Law B, Tata P, Villoria J, Saez B, Mou H, et al. Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. Cell Stem Cell. 2015;16:184-97 pubmed publisher
Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D Souza S, et al. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc. 2015;10:413-25 pubmed publisher
Xu X, Huang L, Futtner C, Schwab B, Rampersad R, Lu Y, et al. The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2. Genes Dev. 2014;28:1929-39 pubmed publisher
Walters M, Gomi K, Ashbridge B, Moore M, Arbelaez V, Heldrich J, et al. Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity. Respir Res. 2013;14:135 pubmed publisher
Huang S, Islam M, O NEILL J, Hu Z, Yang Y, Chen Y, et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 2014;32:84-91 pubmed publisher
Tata P, Mou H, Pardo Saganta A, Zhao R, Prabhu M, Law B, et al. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013;503:218-23 pubmed publisher
Matsuo M, Shimada A, Koshida S, Saga Y, Takeda H. The establishment of rotational polarity in the airway and ependymal cilia: analysis with a novel cilium motility mutant mouse. Am J Physiol Lung Cell Mol Physiol. 2013;304:L736-45 pubmed publisher
Chen H, Matsumoto K, Brockway B, Rackley C, Liang J, Lee J, et al. Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury. Stem Cells. 2012;30:1948-60 pubmed publisher
Mou H, Zhao R, SHERWOOD R, Ahfeldt T, Lapey A, Wain J, et al. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell. 2012;10:385-97 pubmed publisher
Xu X, Rock J, Lu Y, Futtner C, Schwab B, Guinney J, et al. Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. Proc Natl Acad Sci U S A. 2012;109:4910-5 pubmed publisher
product information
Product Type :
Antibody
Product Name :
FOXJ1 Monoclonal Antibody (2A5), eBioscience™
Catalog # :
14-9965-95
Quantity :
10 mg
Price :
US 3000.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Immunocytochemistry: Assay-Dependent, Immunofluorescence: Assay-Dependent, Immunohistochemistry (Paraffin): 1-10 µg/mL, Western Blot: 1-10 µg/mL
Species :
Human, Mouse
Clone :
2A5
Isotype :
IgG1
Storage :
4° C
Description :
Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity, through the repression of NF B activity. FOXJ1 also inhibits the humoral immune response in B cells. FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation and is implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: Assay-Dependent, Immunofluorescence: Assay-Dependent, Immunohistochemistry (Paraffin): 1-10 µg/mL, Western Blot: 1-10 µg/mL
Aliases :
FKHL13; FKHL-13; fork head homologue 4; forkhead box J1; forkhead box protein J1; forkhead transcription factor HFH-4; forkhead-like 13; forkhead-related protein FKHL13; Foxj1; Hepatocyte nuclear factor 3 forkhead homolog 4; HFH4; HFH-4; HNF-3/forkhead homolog 4; MGC35202
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA