product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TCR gamma/delta Monoclonal Antibody (B1.1), eBioscience
catalog :
14-9959-82
quantity :
100 µg
price :
US 145
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B1.1
reactivity :
baboons, African green monkey, human
application :
flow cytometry, mass cytometry
more info or order :
Invitrogen product webpage
citations: 21
Published Application/Species/Sample/DilutionReference
  • mass cytometry; human; loading ...; fig s4a
Jiang Z, Qin L, Tang Y, Liao R, Shi J, He B, et al. Human induced-T-to-natural killer cells have potent anti-tumour activities. Biomark Res. 2022;10:13 pubmed publisher
  • flow cytometry; human
Van Eyck L, Hershfield M, Pombal D, Kelly S, Ganson N, Moens L, et al. Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency. J Allergy Clin Immunol. 2015;135:283-7.e5 pubmed publisher
  • flow cytometry; African green monkey
  • flow cytometry; baboons
Conrad M, Davis W, Koop B. TCR and CD3 antibody cross-reactivity in 44 species. Cytometry A. 2007;71:925-33 pubmed
Sangaletti S, Botti L, Gulino A, Lecis D, Bassani B, Portararo P, et al. SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis. iScience. 2021;24:102510 pubmed publisher
Szabo P, Dogra P, Gray J, Wells S, Connors T, Weisberg S, et al. Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19. Immunity. 2021;54:797-814.e6 pubmed publisher
Ben Othman R, Cai B, Liu A, Varankovich N, He D, Blimkie T, et al. Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults. Front Immunol. 2020;11:580373 pubmed publisher
Dutta I, Postovit L, Siegers G. Apoptosis Induced via Gamma Delta T Cell Antigen Receptor "Blocking" Antibodies: A Cautionary Tale. Front Immunol. 2017;8:776 pubmed publisher
Vasanthakumar A, Xu D, Lun A, Kueh A, van Gisbergen K, Iannarella N, et al. A non-canonical function of Ezh2 preserves immune homeostasis. EMBO Rep. 2017;18:619-631 pubmed publisher
Avalos C, Price S, Forsyth E, Pin J, Shirk E, Bullock B, et al. Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques. J Virol. 2016;90:5643-5656 pubmed publisher
Van Eyck L, De Somer L, Pombal D, Bornschein S, Frans G, Humblet Baron S, et al. Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency. Arthritis Rheumatol. 2015;67:1592-7 pubmed publisher
Nunes Cabaço H, Matoso P, Foxall R, Tendeiro R, Pires A, Carvalho T, et al. Thymic HIV-2 infection uncovers posttranscriptional control of viral replication in human thymocytes. J Virol. 2015;89:2201-8 pubmed publisher
Schubert D, Bode C, Kenefeck R, Hou T, Wing J, Kennedy A, et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med. 2014;20:1410-1416 pubmed publisher
Ye J, Ma C, Wang F, Hsueh E, Toth K, Huang Y, et al. Specific recruitment of ?? regulatory T cells in human breast cancer. Cancer Res. 2013;73:6137-48 pubmed publisher
Barnig C, Cernadas M, Dutile S, Liu X, Perrella M, Kazani S, et al. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med. 2013;5:174ra26 pubmed publisher
Ma C, Zhang Q, Ye J, Wang F, Zhang Y, Wevers E, et al. Tumor-infiltrating ?? T lymphocytes predict clinical outcome in human breast cancer. J Immunol. 2012;189:5029-36 pubmed publisher
Huntington N, Alves N, Legrand N, Lim A, Strick Marchand H, Mention J, et al. IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo. Proc Natl Acad Sci U S A. 2011;108:6217-22 pubmed publisher
Kong Y, Cao W, Xi X, Ma C, Cui L, He W. The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D. Blood. 2009;114:310-7 pubmed publisher
Deetz C, Hebbeler A, Propp N, Cairo C, Tikhonov I, Pauza C. Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonist Pam3Cys. Infect Immun. 2006;74:4505-11 pubmed
De Libero G. Sentinel function of broadly reactive human gamma delta T cells. Immunol Today. 1997;18:22-6 pubmed
Merlo A, Filgueira L, Zuber M, Juretic A, Harder F, Gratzl O, et al. T-cell receptor V-gene usage in neoplasms of the central nervous system. A comparative analysis in cultured tumor infiltrating and peripheral blood T cells. J Neurosurg. 1993;78:630-7 pubmed
Nick S, Pileri P, Tongiani S, Uematsu Y, Kappos L, De Libero G. T cell receptor gamma delta repertoire is skewed in cerebrospinal fluid of multiple sclerosis patients: molecular and functional analyses of antigen-reactive gamma delta clones. Eur J Immunol. 1995;25:355-63 pubmed
product information
Product Type :
Antibody
Product Name :
TCR gamma/delta Monoclonal Antibody (B1.1), eBioscience
Catalog # :
14-9959-82
Quantity :
100 µg
Price :
US 145
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 µg/test
Species :
Human
Clone :
B1.1
Isotype :
IgG1, kappa
Storage :
4° C
Description :
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test
Aliases :
RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA