MHC I Free Chain Monoclonal Antibody (A4), eBioscience | Invitrogen 14-9958-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MHC I Free Chain Monoclonal Antibody (A4), eBioscience

catalog :

14-9958-82

quantity :

100 µg

price :

US 231.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human

application :

immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:200; loading ...; fig 1c	Middha S, Yaeger R, Shia J, Stadler Z, King S, Guercio S, et al. Majority of B2M-Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High. JCO Precis Oncol. 2019;3: pubmed publisher
	Pourmaleki M, Young J, Socci N, Chiang S, Edelweiss M, Li Y, et al. Extramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A. Oncotarget. 2019;10:6152-6167 pubmed publisher
	Lange T, Ullrich S, Müller I, Nentwich M, Stübke K, Feldhaus S, et al. Human prostate cancer in a clinically relevant xenograft mouse model: identification of ?(1,6)-branched oligosaccharides as a marker of tumor progression. Clin Cancer Res. 2012;18:1364-73 pubmed publisher
	Yuan J, Page D, Ku G, Li Y, Mu Z, Ariyan C, et al. Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy. Cancer Immun. 2010;10:1 pubmed
	Lopez de Castro J, Barbosa J, Krangel M, Biro P, Strominger J. Structural analysis of the functional sites of class I HLA antigens. Immunol Rev. 1985;85:149-68 pubmed

product information

Product Type :

Antibody

Product Name :

MHC I Free Chain Monoclonal Antibody (A4), eBioscience

Catalog # :

14-9958-82

Quantity :

100 µg

Price :

US 231.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent

Species :

Human

Clone :

Isotype :

IgG1, kappa

Storage :

4° C

Description :

There are three class I alpha-chain genes in humans, called HLA-A, -B and -C. Normally, HLA class I proteins are associated non-covalently with B2 microglobulin (B2M). The function of the HLA class I complex is to present peptides derived from intracellular pathogens, including viral pathogens, on the cell surface to antigen specific CD8+ cytotoxic T cells. Class I HLA is expressed by the majority of nucleated cells. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent

Aliases :

MHC Free

more info or order :

Invitrogen product webpage