HLA-E Monoclonal Antibody (3D12HLA-E), eBioscience™ | Invitrogen 14-9953-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HLA-E Monoclonal Antibody (3D12HLA-E), eBioscience™

catalog :

14-9953-80

quantity :

25 µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3D12HLA-E

reactivity :

human

application :

western blot, immunoprecipitation, flow cytometry

citations: 5

Reference
Gornalusse G, Hirata R, Funk S, Riolobos L, Lopes V, Manske G, et al. HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells. Nat Biotechnol. 2017;35:765-772 pubmed publisher
Veluchamy J, Heeren A, Spanholtz J, van Eendenburg J, Heideman D, Kenter G, et al. High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status. Cancer Immunol Immunother. 2017;66:51-61 pubmed publisher
Griffin B, Gram A, Mulder A, van Leeuwen D, Claas F, Wang F, et al. EBV BILF1 evolved to downregulate cell surface display of a wide range of HLA class I molecules through their cytoplasmic tail. J Immunol. 2013;190:1672-84 pubmed publisher
Tjwa E, van Oord G, Biesta P, Boonstra A, Janssen H, Woltman A. Restoration of TLR3-activated myeloid dendritic cell activity leads to improved natural killer cell function in chronic hepatitis B virus infection. J Virol. 2012;86:4102-9 pubmed publisher
Enqvist M, Nilsonne G, Hammarfjord O, Wallin R, Björkström N, Björnstedt M, et al. Selenite induces posttranscriptional blockade of HLA-E expression and sensitizes tumor cells to CD94/NKG2A-positive NK cells. J Immunol. 2011;187:3546-54 pubmed publisher

product information

Product Type :

Antibody

Product Name :

HLA-E Monoclonal Antibody (3D12HLA-E), eBioscience™

Catalog # :

14-9953-80

Quantity :

25 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 µg/test, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent

Species :

Human

Clone :

3D12HLA-E

Isotype :

IgG1, kappa

Storage :

4° C

Description :

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent

Aliases :

DAMA-277I14.1; DAQB-90C11.16; DKFZp686P19218; EA1.2; EA2.1; FLJ26655; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, E alpha chain; HLA-6.2; HLAE; HLA-E; lymphocyte antigen; major histocompatibility complex, class I, E; MHC; MHC 1; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC1; QA1; sHLA-E; Soluble HLA class I histocompatibility antigen, alpha chain E