This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD281 (TLR1) Monoclonal Antibody (GD2.F4), eBioscience
catalog :
14-9911-80
quantity :
25 ug
price :
US 154.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
GD2.F4

The same clone is also sold as:
reactivity :
human
application :
immunohistochemistry, flow cytometry
citations: 12
Reference
He Q, Yu C, Wu G, Wang K, Ni Y, Guo X, et al. A novel alternative for pyrogen detection based on a transgenic cell line. Signal Transduct Target Ther. 2024;9:33 pubmed publisher
Giannakopoulos S, Strange D, Jiyarom B, Abdelaal O, Bradshaw A, Nerurkar V, et al. In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury. PLoS Pathog. 2023;19:e1011409 pubmed publisher
da Rocha Sobrinho H, Saar Gomes R, da Silva D, Quixabeira V, Joosten L, Ribeiro De Barros Cardoso C, et al. Toll-like receptor 10 controls TLR2-induced cytokine production in monocytes from patients with Parkinson's disease. J Neurosci Res. 2021;99:2511-2524 pubmed publisher
Bzowska M, Nogieć A, Bania K, Zygmunt M, Zarebski M, Dobrucki J, et al. Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages. J Leukoc Biol. 2017;102:763-774 pubmed publisher
Hart B, Tapping R. Differential trafficking of TLR1 I602S underlies host protection against pathogenic mycobacteria. J Immunol. 2012;189:5347-55 pubmed publisher
Salem S, Abu Zeid R, Nada O. Immunohistochemical study of Toll-like receptors 1 and 2 expression in cutaneous lichen planus lesions. Arch Dermatol Res. 2013;305:125-31 pubmed publisher
Tukel C, Nishimori J, Wilson R, Winter M, Keestra A, van Putten J, et al. Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms. Cell Microbiol. 2010;12:1495-505 pubmed publisher
Guan Y, Ranoa D, Jiang S, Mutha S, Li X, Baudry J, et al. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling. J Immunol. 2010;184:5094-103 pubmed publisher
Sandor F, Latz E, Re F, Mandell L, Repik G, Golenbock D, et al. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling. J Cell Biol. 2003;162:1099-110 pubmed
Krutzik S, Ochoa M, Sieling P, Uematsu S, Ng Y, Legaspi A, et al. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med. 2003;9:525-32 pubmed
Visintin A, Mazzoni A, Spitzer J, Wyllie D, Dower S, Segal D. Regulation of Toll-like receptors in human monocytes and dendritic cells. J Immunol. 2001;166:249-55 pubmed
Wyllie D, Kiss Toth E, Visintin A, Smith S, Boussouf S, Segal D, et al. Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses. J Immunol. 2000;165:7125-32 pubmed
product information
Product Type :
Antibody
Product Name :
CD281 (TLR1) Monoclonal Antibody (GD2.F4), eBioscience
Catalog # :
14-9911-80
Quantity :
25 ug
Price :
US 154.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 ug/test, Immunohistochemistry: Assay-Dependent
Species :
Human
Clone :
GD2.F4
Isotype :
IgG1, kappa
Storage :
4 C
Description :
TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test, Immunohistochemistry: Assay-Dependent
Aliases :
CD281; KIAA0012; rsc786; TIL; TIL. LPRS5; TLR1; toll like receptor 1; Toll/interleukin-1 receptor-like protein; toll-like receptor 1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA