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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
GFAP Monoclonal Antibody (GA5), eBioscience™
catalog :
14-9892-80
quantity :
25 µg
price :
US 179
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
GA5
reactivity :
human, mouse, rat, chicken, pigs , domestic rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 40
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; loading ...; fig 3f
Wang C, Zhang F, Jiang S, Siedlak S, Shen L, Perry G, et al. Estrogen receptor-? is localized to neurofibrillary tangles in Alzheimer's disease. Sci Rep. 2016;6:20352 pubmed publisher
Zaman V, Drasites K, Myatich A, Shams R, Shields D, Matzelle D, et al. Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease. Int J Mol Sci. 2022;23: pubmed publisher
Battistella E, Schniete J, Wesencraft K, Quintana J, McConnell G. Light-sheet mesoscopy with the Mesolens provides fast sub-cellular resolution imaging throughout large tissue volumes. iScience. 2022;25:104797 pubmed publisher
Gan Q, Wong A, Zhang Z, Na H, Tian H, Tao Q, et al. Monomeric C-reactive protein induces the cellular pathology of Alzheimer's disease. Alzheimers Dement (N Y). 2022;8:e12319 pubmed publisher
Kumar P, Lim A, Hazirah S, Chua C, Ngoh A, Poh S, et al. Single-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling. Nat Neurosci. 2022;: pubmed publisher
Rayaprolu S, Bitarafan S, Santiago J, Betarbet R, Sunna S, Cheng L, et al. Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain. Nat Commun. 2022;13:2927 pubmed publisher
Marini C, Cossu V, Kumar M, Milanese M, Cortese K, Bruno S, et al. The Role of Endoplasmic Reticulum in the Differential Endurance against Redox Stress in Cortical and Spinal Astrocytes from the Newborn SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis. Antioxidants (Basel). 2021;10: pubmed publisher
Wu J, Chen N, Liu Y, Godlewski G, Kaplan H, Shrader S, et al. Studies of involvement of G-protein coupled receptor-3 in cannabidiol effects on inflammatory responses of mouse primary astrocytes and microglia. PLoS ONE. 2021;16:e0251677 pubmed publisher
Gebril H, Wahba A, Zhou X, Lai T, Alharfoush E, Dicicco Bloom E, et al. Developmental Role of Adenosine Kinase in the Cerebellum. Eneuro. 2021;8: pubmed publisher
Challagundla N, Agrawal Rajput R. microRNAs (miR 9, 124, 155 and 224) transdifferentiate mouse macrophages to neurons. Exp Cell Res. 2021;402:112563 pubmed publisher
. CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS. Neurol Neuroimmunol Neuroinflamm. 2021;8: pubmed publisher
Borggrewe M, Grit C, Vainchtein I, Brouwer N, Wesseling E, Laman J, et al. Regionally diverse astrocyte subtypes and their heterogeneous response to EAE. Glia. 2021;69:1140-1154 pubmed publisher
Lee E, Winston Gray C, Barlow J, Rissman R, Jeste D. Plasma Levels of Neuron- and Astrocyte-Derived Exosomal Amyloid Beta1-42, Amyloid Beta1-40, and Phosphorylated Tau Levels in Schizophrenia Patients and Non-psychiatric Comparison Subjects: Relationships With Cognitive Functioning and Psychopathology. Front Psychiatry. 2020;11:532624 pubmed publisher
Martins C, Neves L, de Oliveira M, Bagatini P, Barboza R, Mestriner R, et al. Neuroprotective effect of ACTH on collagenase-induced peri-intraventricular hemorrhage in newborn male rats. Sci Rep. 2020;10:17734 pubmed publisher
Upadhyay M, Milliner C, Bell B, Bonilha V. Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1. Redox Biol. 2020;:101623 pubmed publisher
Liu J, Zhu Y, Guo Y, Lin L, Wang Z, Gu F, et al. Inhibition of GSK3β and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production. Front Pharmacol. 2020;11:812 pubmed publisher
Oh J, Hwang T, Jang J, Park J, Ryu Y, Lee H, et al. Muscovite nanoparticles mitigate neuropathic pain by modulating the inflammatory response and neuroglial activation in the spinal cord. Neural Regen Res. 2020;15:2162-2168 pubmed publisher
Rayaprolu S, Gao T, Xiao H, Ramesha S, Weinstock L, Shah J, et al. Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease. Mol Neurodegener. 2020;15:28 pubmed publisher
Kosuge Y, Kaneko E, Nango H, Miyagishi H, Ishige K, Ito Y. Bidens pilosa Extract Administered after Symptom Onset Attenuates Glial Activation, Improves Motor Performance, and Prolongs Survival in a Mouse Model of Amyotrophic Lateral Sclerosis. Oxid Med Cell Longev. 2020;2020:1020673 pubmed publisher
Harland M, Torres S, Liu J, Wang X. Neuronal Mitochondria Modulation of LPS-Induced Neuroinflammation. J Neurosci. 2020;40:1756-1765 pubmed publisher
Wong C, Cheung N, Ho C, Barathi V, Storm G, Wong T. Characterisation of the inflammatory cytokine and growth factor profile in a rabbit model of proliferative vitreoretinopathy. Sci Rep. 2019;9:15419 pubmed publisher
Yan J, Zhao Q, Gabrusiewicz K, Kong L, Xia X, Wang J, et al. FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nat Commun. 2019;10:448 pubmed publisher
Cheng W, Martens K, Bashir A, Cheung H, Stukas S, Gibbs E, et al. CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice. Alzheimers Res Ther. 2019;11:6 pubmed publisher
Ogrodnik M, Zhu Y, Langhi L, Tchkonia T, Krüger P, Fielder E, et al. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. Cell Metab. 2019;29:1061-1077.e8 pubmed publisher
Ke X, Fu Q, Majnik A, Cohen S, Liu Q, Lane R. Adverse early life environment induces anxiety-like behavior and increases expression of FKBP5 mRNA splice variants in mouse brain. Physiol Genomics. 2018;50:973-981 pubmed publisher
Weider M, Starost L, Groll K, Küspert M, Sock E, Wedel M, et al. Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nat Commun. 2018;9:899 pubmed publisher
Jamali N, Wang S, Darjatmoko S, Sorenson C, Sheibani N. Vitamin D receptor expression is essential during retinal vascular development and attenuation of neovascularization by 1, 25(OH)2D3. PLoS ONE. 2017;12:e0190131 pubmed publisher
Wu L, Ye Z, Zhou C, Wang C, Xie G, Zhang X, et al. Roles of Pannexin-1 Channels in Inflammatory Response through the TLRs/NF-Kappa B Signaling Pathway Following Experimental Subarachnoid Hemorrhage in Rats. Front Mol Neurosci. 2017;10:175 pubmed publisher
Jin W, Shi S, Li Z, Li M, Wood K, Gonzales R, et al. Depletion of microglia exacerbates postischemic inflammation and brain injury. J Cereb Blood Flow Metab. 2017;37:2224-2236 pubmed publisher
Ibiza S, García Cassani B, Ribeiro H, Carvalho T, Almeida L, Marques R, et al. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. Nature. 2016;535:440-443 pubmed publisher
Michaels D, Leibowitz J, Azaiza M, Shil P, Shama S, Kutish G, et al. Cellular Microbiology of Mycoplasma canis. Infect Immun. 2016;84:1785-1795 pubmed publisher
Sundarkrishnan L, Bradish J, Oliai B, Hosler G. Cutaneous Cellular Pseudoglandular Schwannoma: An Unusual Histopathologic Variant. Am J Dermatopathol. 2016;38:315-8 pubmed publisher
Ertoy Baydar D, Kosemehmetoglu K, Aydin O, Bridge J, Buyukeren B, Aki F. Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature. Diagn Pathol. 2015;10:186 pubmed publisher
Hung H, Hsiao Y, Gean P. Learning induces sonic hedgehog signaling in the amygdala which promotes neurogenesis and long-term memory formation. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
Vazquez Cintron E, Vakulenko M, Band P, Stanker L, Johnson E, Ichtchenko K. Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm. PLoS ONE. 2014;9:e85517 pubmed publisher
Mullins C, Schneider B, Stockhammer F, Krohn M, Classen C, Linnebacher M. Establishment and characterization of primary glioblastoma cell lines from fresh and frozen material: a detailed comparison. PLoS ONE. 2013;8:e71070 pubmed publisher
Quinlan R, Brenner M, Goldman J, Messing A. GFAP and its role in Alexander disease. Exp Cell Res. 2007;313:2077-87 pubmed
McLendon R, Bigner D. Immunohistochemistry of the glial fibrillary acidic protein: basic and applied considerations. Brain Pathol. 1994;4:221-8 pubmed
Rasmussen S, Bock E, Warecka K, Althage G. Quantitation of glial fibrillary acidic protein in human brain tumours. Br J Cancer. 1980;41:113-6 pubmed
Mokuno K, Kamholz J, Behrman T, Black C, Sessa M, Feinstein D, et al. Neuronal modulation of Schwann cell glial fibrillary acidic protein (GFAP). J Neurosci Res. 1989;23:396-405 pubmed
product information
Product Type :
Antibody
Product Name :
GFAP Monoclonal Antibody (GA5), eBioscience™
Catalog # :
14-9892-80
Quantity :
25 µg
Price :
US 179
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Chicken, Human, Mouse, Porcine, Rabbit, Rat
Applications :
Flow Cytometry: Assay-Dependent, Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 0.5-5 µg/mL
Species :
Chicken, Human, Mouse, Porcine, Rabbit, Rat
Clone :
GA5
Isotype :
IgG1
Storage :
4° C
Description :
GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent, Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 0.5-5 µg/mL
Aliases :
AI836096; ALXDRD; cb345; class III intermediate filament protein; etID36982.3; FLJ45472; gfap; GFAP epsilon; gfap protein; gfapl; Glial fibrillary acidic protein; glial fibrillary acidic protein alpha; I79_011607; intermediate filament; intermediate filament protein; intermediate filament protein; GFAP; Unknown (protein for MGC:139638); wu:fb34h11; wu:fk42c12; xx:af506734; zgc:110485; zGFAP; intermediate filament protein; zrf-1 antigen
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA