SAP (SLAM-Associated Protein) Monoclonal Antibody (10C4.2), eBioscience | Invitrogen 14-9888-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SAP (SLAM-Associated Protein) Monoclonal Antibody (10C4.2), eBioscience

catalog :

14-9888-82

quantity :

100 ug

price :

US 353.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10C4.2

reactivity :

human

application :

western blot, immunocytochemistry

citations: 3

Reference
Hernández Del Pino R, Pellegrini J, Rovetta A, Peña D, Álvarez G, Rolandelli A, et al. Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses. Immunol Cell Biol. 2017;95:716-728 pubmed publisher
Yusuf I, Kageyama R, Monticelli L, Johnston R, DiToro D, Hansen K, et al. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol. 2010;185:190-202 pubmed publisher
Sayos J, Martin M, Chen A, Simarro M, Howie D, Morra M, et al. Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP. Blood. 2001;97:3867-74 pubmed

product information

Product Type :

Antibody

Product Name :

SAP (SLAM-Associated Protein) Monoclonal Antibody (10C4.2), eBioscience

Catalog # :

14-9888-82

Quantity :

100 ug

Price :

US 353.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: Assay-Dependent, Western Blot: 5 ug/mL

Species :

Human

Clone :

10C4.2

Isotype :

IgG1, kappa

Storage :

4 C

Description :

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-Dependent, Western Blot: 5 ug/mL

Aliases :

DSHP; Duncan disease homolog; Duncan disease SH2-protein; Duncan's disease; EBVS; FLJ18687; FLJ92177; Gm686; HGNC:10820; IMD5; LYP; MTCP1; RGD1562408; RP5-1052M9.3; SAP; SAP/SH2D1A; SH2 domain containing 1A; SH2 domain protein 1A; SH2 domain-containing protein 1A; SH2D1A; signaling lymphocyte activation molecule-associated protein; signaling lymphocytic activation molecule-associated protein; SLAM associated protein/SH2 domain protein 1A; SLAM-associated protein; SLAM-associated protein isoform SAP-2; T cell signal transduction molecule SAP; T-cell signal transduction molecule SAP; Xlp; XLPD; XLPD1