This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Fibronectin Monoclonal Antibody (FN-3), eBioscience
catalog :
14-9869-82
quantity :
100 ug
price :
US 313.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Fn-3

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 9
Reference
Betriu N, Andreeva A, Alonso A, Semino C. Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds. Biomedicines. 2022;10: pubmed publisher
Gao H, Tian Q, Zhu L, Feng J, Zhou Y, Yang J. 3D Extracellular Matrix Regulates the Activity of T Cells and Cancer Associated Fibroblasts in Breast Cancer. Front Oncol. 2021;11:764204 pubmed publisher
Marwick J, Elliott R, Longden J, Makda A, Hirani N, Dhaliwal K, et al. Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients. SLAS Discov. 2021;26:1091-1106 pubmed publisher
Good R, Eley J, Gower E, Butt G, Blanchard A, Fisher A, et al. A high content, phenotypic 'scar-in-a-jar' assay for rapid quantification of collagen fibrillogenesis using disease-derived pulmonary fibroblasts. BMC Biomed Eng. 2019;1:14 pubmed publisher
Bon H, Hales P, Lumb S, Holdsworth G, Johnson T, Qureshi O, et al. Spontaneous Extracellular Matrix Accumulation in a Human in vitro Model of Renal Fibrosis Is Mediated by αV Integrins. Nephron. 2019;:1-23 pubmed publisher
Tomasini Johansson B, Zbyszynski P, Toraason I, Peters D, Kwon G. PEGylated pUR4/FUD peptide inhibitor of fibronectin fibrillogenesis decreases fibrosis in murine Unilateral Ureteral Obstruction model of kidney disease. PLoS ONE. 2018;13:e0205360 pubmed publisher
Cseh B, Fernandez Sauze S, Grall D, Schaub S, Doma E, Van Obberghen Schilling E. Autocrine fibronectin directs matrix assembly and crosstalk between cell-matrix and cell-cell adhesion in vascular endothelial cells. J Cell Sci. 2010;123:3989-99 pubmed publisher
Akiyama S, Yamada K, Hayashi M. The structure of fibronectin and its role in cellular adhesion. J Supramol Struct Cell Biochem. 1981;16:345-8 pubmed
Keen J, Chang S, Taylor Papadimitriou J. Monoclonal antibodies that distinguish between human cellular and plasma fibronectin. Mol Biol Med. 1984;2:15-27 pubmed
product information
Product Type :
Antibody
Product Name :
Fibronectin Monoclonal Antibody (FN-3), eBioscience
Catalog # :
14-9869-82
Quantity :
100 ug
Price :
US 313.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Immunocytochemistry: 0.025-0.5 ug/mL, Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 0.5 ug/mL
Species :
Human
Clone :
FN-3
Isotype :
IgG1
Storage :
4 C
Description :
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 0.025-0.5 ug/mL, Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 0.5 ug/mL
Aliases :
Anastellin; CIG; Cold insoluble globulin (CIG); Cold-insoluble globulin; cumulus cell-specific fibronectin 1 transcript; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; E330027I09; ED-B; embryo-specific fibronectin 1 transcript; ferritin L subunit; ferritin L-chain; FIBNEC; fibronectin; fibronectin 1; fibronectin ED-A- region; fibronectin ED-B+ region; fibronectin variable region; FINC; FN; FN1; fn-1; FNZ; GFND; GFND2; LETS; LOW QUALITY PROTEIN: fibronectin; Migration stimulating factor (MSF); migration-stimulating factor; MSF; Ugl-Y1; Ugl-Y2; Ugl-Y3
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA