IRF4 Monoclonal Antibody (3E4), eBioscience™ | Invitrogen 14-9858-95 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IRF4 Monoclonal Antibody (3E4), eBioscience™

catalog :

14-9858-95

quantity :

10 mg

price :

US 3000.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

3E4

reactivity :

human, mouse

application :

western blot

citations: 13

Reference
Chakraborty P, Vaena S, Thyagarajan K, Chatterjee S, Al Khami A, Selvam S, et al. Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity. Cell Rep. 2019;28:1879-1893.e7 pubmed publisher
Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina S, et al. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019;10:1084 pubmed publisher
Chen W, Nyuydzefe M, Weiss J, Zhang J, Waksal S, Zanin Zhorov A. ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells. Sci Rep. 2018;8:16636 pubmed publisher
Ogawa C, Bankoti R, Nguyen T, Hassanzadeh Kiabi N, Nadeau S, Porritt R, et al. Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells. Cell Rep. 2018;25:19-28.e5 pubmed publisher
Chandra J, Kuo P, Hahn A, Belz G, Frazer I. Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function. Immunol Cell Biol. 2017;95:215-223 pubmed publisher
Allison K, Sajti E, Collier J, Gosselin D, Troutman T, Stone E, et al. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. elife. 2016;5: pubmed publisher
Abdala Valencia H, Soveg F, Cook Mills J. Î³-Tocopherol supplementation of allergic female mice augments development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates. Am J Physiol Lung Cell Mol Physiol. 2016;310:L759-71 pubmed publisher
Hoffmann M, Molina Mendiola C, Nelson A, Parks C, Reyes E, Hansen M, et al. Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo. Sci Adv. 2015;1:e1500415 pubmed publisher
Mohapatra A, Van Dyken S, Schneider C, Nussbaum J, Liang H, Locksley R. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunol. 2016;9:275-86 pubmed publisher
NÃ¼ndel K, Green N, Shaffer A, Moody K, Busto P, Eilat D, et al. Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses. J Immunol. 2015;194:2504-12 pubmed publisher
Cohen S, Smith N, McDougal C, Pepper M, Shah S, Yap G, et al. Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells. J Immunol. 2015;194:210-22 pubmed
Watchmaker P, Lahl K, Lee M, Baumjohann D, Morton J, Kim S, et al. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat Immunol. 2014;15:98-108 pubmed publisher
Xiao X, Balasubramanian S, Liu W, Chu X, Wang H, Taparowsky E, et al. OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nat Immunol. 2012;13:981-90 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IRF4 Monoclonal Antibody (3E4), eBioscience™

Catalog # :

14-9858-95

Quantity :

10 mg

Price :

US 3000.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Western Blot: 5 µg/mL

Species :

Human, Mouse

Clone :

3E4

Isotype :

IgG1, kappa

Storage :

4° C

Description :

The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 5 µg/mL

Aliases :

AI385587; Interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP