Lamin A Monoclonal Antibody (4A4-A4), eBioscience | Invitrogen 14-9848-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Lamin A Monoclonal Antibody (4A4-A4), eBioscience

catalog :

14-9848-82

quantity :

100 ug

price :

US 616.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4A4-A4

reactivity :

human, mouse

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

Lamin A Monoclonal Antibody (4A4-A4), eBioscience

Catalog # :

14-9848-82

Quantity :

100 ug

Price :

US 616.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 0.06 ug/mL, Western Blot: 0.2 ug/mL

Species :

Human, Mouse

Clone :

4A4-A4

Isotype :

IgG1, kappa

Storage :

4 C, do not freeze

Description :

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.

Immunogen :

KLH-conjugated peptide corresponding to the C-terminus of human Lamin A

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 0.06 ug/mL, Western Blot: 0.2 ug/mL

Aliases :

70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; lamin-A/C; LDP1; LFP; LGMD1B; LMN1; Lmna; LMNA protein; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; renal carcinoma antigen NY-REN-32; unnamed protein product