This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Caspase 1 Monoclonal Antibody (5B10), eBioscience
catalog :
14-9832-37
quantity :
2 mg
price :
US 1474.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
5B10

The same clone is also sold as:
reactivity :
mouse
application :
western blot
citations: 25
Reference
Yalcınkaya M, Liu W, Xiao T, Abramowicz S, Wang R, Wang N, et al. Cholesterol trafficking to the ER leads to the activation of CaMKII/JNK/NLRP3 and promotes atherosclerosis. J Lipid Res. 2024;65:100534 pubmed publisher
Anand A, Chandana M, Ghosh S, Das R, Singh N, Vaishalli P, et al. Significance of Plasmodium berghei Amino Acid Transporter 1 in Food Vacuole Functionality and Its Association with Cerebral Pathogenesis. Microbiol Spectr. 2023;11:e0494322 pubmed publisher
Mantri M, Hinchman M, McKellar D, Wang M, Cross S, Parker J, et al. Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis. Nat Cardiovasc Res. 2022;1:946-960 pubmed publisher
Feng Y, Li W, Wang Z, Zhang R, Li Y, Zang L, et al. The p-STAT3/ANXA2 axis promotes caspase-1-mediated hepatocyte pyroptosis in non-alcoholic steatohepatitis. J Transl Med. 2022;20:497 pubmed publisher
Chandana M, Anand A, Ghosh S, Das R, Beura S, Jena S, et al. Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice. Nat Commun. 2022;13:4028 pubmed publisher
Moretti J, Jia B, Hutchins Z, Roy S, Yip H, Wu J, et al. Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome. Nat Immunol. 2022;23:705-717 pubmed publisher
Xiao R, Mansour A, Huang W, Hassan Q, Wilkins R, Komatineni S, et al. Adipocyte CD1d Gene Transfer Induces T Cell Expansion and Adipocyte Inflammation in CD1d Knockout Mice. J Immunol. 2022;208:2109-2121 pubmed publisher
Parshenkov A, Hennet T. Glycosylation-Dependent Induction of Programmed Cell Death in Murine Adenocarcinoma Cells. Front Immunol. 2022;13:797759 pubmed publisher
Yalcınkaya M, Liu W, Islam M, Kotini A, Gusarova G, Fidler T, et al. Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein. Sci Rep. 2021;11:24432 pubmed publisher
Bellut M, Papp L, Bieber M, Kraft P, Stoll G, Schuhmann M. NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood-brain barrier integrity in murine stroke. Cell Death Dis. 2021;13:20 pubmed publisher
Singh S, Singh P, Jha A, Naik P, Joseph J, Giri S, et al. Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection. Cell Rep Med. 2021;2:100277 pubmed publisher
Brocker C, Kim D, Melia T, Karri K, Velenosi T, Takahashi S, et al. Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting. Nat Commun. 2020;11:5847 pubmed publisher
Tummers B, Mari L, Guy C, Heckmann B, Rodriguez D, Rühl S, et al. Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis. Immunity. 2020;52:994-1006.e8 pubmed publisher
He M, Chiang H, Luo H, Zheng Z, Qiao Q, Wang L, et al. An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. Cell Metab. 2020;31:580-591.e5 pubmed publisher
Sanjo H, Nakayama J, Yoshizawa T, Fehling H, Akira S, Taki S. Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death. J Immunol. 2019;203:783-788 pubmed publisher
Luo H, Mu W, Karki R, Chiang H, Mohrin M, Shin J, et al. Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging. Cell Rep. 2019;26:945-954.e4 pubmed publisher
Faro J, Romero R, Schwenkel G, Garcia Flores V, Arenas Hernandez M, Leng Y, et al. Inflammation-Induced Intra-Amniotic inflammation induces preterm birth by Activating the NLRP3 inflammasome. Biol Reprod. 2018;: pubmed publisher
Ma J, Jiang D, Gong X, Shao W, Zhu Z, Xu W, et al. Free immunoglobulin light chain (FLC) promotes murine colitis and colitis-associated colon carcinogenesis by activating the inflammasome. Sci Rep. 2017;7:5165 pubmed publisher
Lood C, Blanco L, Purmalek M, Carmona Rivera C, De Ravin S, Smith C, et al. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat Med. 2016;22:146-53 pubmed publisher
Marty Roix R, Vladimer G, Pouliot K, Weng D, Buglione Corbett R, West K, et al. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. J Biol Chem. 2016;291:1123-36 pubmed publisher
Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, et al. Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury. Nat Commun. 2015;6:7360 pubmed publisher
Kaminski J, Schattgen S, Tzeng T, Bode C, Klinman D, Fitzgerald K. Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation. J Immunol. 2013;191:3876-83 pubmed publisher
Mishra B, Rathinam V, Martens G, Martinot A, Kornfeld H, Fitzgerald K, et al. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?. Nat Immunol. 2013;14:52-60 pubmed publisher
Rathinam V, Vanaja S, Waggoner L, Sokolovska A, Becker C, Stuart L, et al. TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell. 2012;150:606-19 pubmed publisher
Bueter C, Lee C, Rathinam V, Healy G, Taron C, Specht C, et al. Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis. J Biol Chem. 2011;286:35447-55 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Caspase 1 Monoclonal Antibody (5B10), eBioscience
Catalog # :
14-9832-37
Quantity :
2 mg
Price :
US 1474.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Western Blot: 1-5 ug/mL
Species :
Mouse
Clone :
5B10
Isotype :
IgG2a
Storage :
4 C
Description :
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1-b and IL-18. Caspase-1 was initially identified as an IL-1-b-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.
Format :
Liquid
Applications w/Dilutions :
Western Blot: 1-5 ug/mL
Aliases :
CASP1; CASP-1; CASP1 nirs variant 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase1; caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA