GP6 Monoclonal Antibody (HY101), eBioscience | Invitrogen 14-9813-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GP6 Monoclonal Antibody (HY101), eBioscience

catalog :

14-9813-81

quantity :

50 ug

price :

US 89.50

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HY101

The same clone is also sold as:

BioLegend: 383802

reactivity :

human

application :

western blot, flow cytometry

citations: 5

Reference
Hermans C, Wittevrongel C, Thys C, Smethurst P, Van Geet C, Freson K. A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder. J Thromb Haemost. 2009;7:1356-63 pubmed publisher
Moroi M, Jung S. Platelet glycoprotein VI: its structure and function. Thromb Res. 2004;114:221-33 pubmed
Best D, Senis Y, Jarvis G, Eagleton H, Roberts D, Saito T, et al. GPVI levels in platelets: relationship to platelet function at high shear. Blood. 2003;102:2811-8 pubmed
Locke D, Liu C, Peng X, Chen H, Kahn M. Fc Rgamma -independent signaling by the platelet collagen receptor glycoprotein VI. J Biol Chem. 2003;278:15441-8 pubmed
Chen H, Locke D, Liu Y, Liu C, Kahn M. The platelet receptor GPVI mediates both adhesion and signaling responses to collagen in a receptor density-dependent fashion. J Biol Chem. 2002;277:3011-9 pubmed

product information

Product Type :

Antibody

Product Name :

GP6 Monoclonal Antibody (HY101), eBioscience

Catalog # :

14-9813-81

Quantity :

50 ug

Price :

US 89.50

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.25 ug/test, Western Blot: Assay-Dependent

Species :

Human

Clone :

HY101

Isotype :

IgG1, kappa

Storage :

4 C

Description :

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 ug/test, Western Blot: Assay-Dependent

Aliases :

9830166G18Rik; BDPLT11; Glycoprotein 5; glycoprotein 6; glycoprotein 6 (platelet); glycoprotein VI (platelet); glycoprotein VI platelet; Gm469; GP6; GPIV; GPVI; platelet collagen receptor; platelet glycoprotein VI