SPI-B Monoclonal Antibody (235D), eBioscience | Invitrogen 14-9790-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SPI-B Monoclonal Antibody (235D), eBioscience

catalog :

14-9790-82

quantity :

100 ug

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

235D

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 4

Reference
Montes Moreno S, Ramos Medina R, Martínez López A, Barrionuevo Cornejo C, Parra Cubillos A, Quintana Truyenque S, et al. SPIB, a novel immunohistochemical marker for human blastic plasmacytoid dendritic cell neoplasms: characterization of its expression in major hematolymphoid neoplasms. Blood. 2013;121:643-7 pubmed publisher
Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, et al. The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. Nat Immunol. 2012;13:729-36 pubmed publisher
Su G, Ip H, Cobb B, Lu M, Chen H, Simon M. The Ets protein Spi-B is expressed exclusively in B cells and T cells during development. J Exp Med. 1996;184:203-14 pubmed
Ray D, Bosselut R, Ghysdael J, Mattei M, Tavitian A, Moreau Gachelin F. Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol Cell Biol. 1992;12:4297-304 pubmed

product information

Product Type :

Antibody

Product Name :

SPI-B Monoclonal Antibody (235D), eBioscience

Catalog # :

14-9790-82

Quantity :

100 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: Assay-Dependent

Species :

Human

Clone :

235D

Isotype :

IgG1, kappa

Storage :

4 C

Description :

Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: Assay-Dependent

Aliases :

B42b-like; Ets transcription factor Spi-B; Spi-1/PU.1 related; Spib; SPI-B; Spi-B transcription factor; Spi-B transcription factor (Spi-1/PU.1 related); Transcription factor Spi-B