Arginase 1 Monoclonal Antibody (sl6arg), eBioscience™ | Invitrogen 14-9779-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Arginase 1 Monoclonal Antibody (sl6arg), eBioscience™

catalog :

14-9779-82

quantity :

100µg

price :

US 275

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

sl6arg

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; fig 2	Lee R, Reese C, Carmen Lopez G, Perry B, Bonner M, Zemskova M, et al. Deficient Adipogenesis of Scleroderma Patient and Healthy African American Monocytes. Front Pharmacol. 2017;8:174 pubmed publisher
	Raber P, Ochoa A, Rodriguez P. Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives. Immunol Invest. 2012;41:614-34 pubmed publisher
	Fujiwara M, Kwok S, Yano H, Pai R. Arginase-1 is a more sensitive marker of hepatic differentiation than HepPar-1 and glypican-3 in fine-needle aspiration biopsies. Cancer Cytopathol. 2012;120:230-7 pubmed publisher
	Lechner M, Liebertz D, Epstein A. Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J Immunol. 2010;185:2273-84 pubmed publisher
	Pesce J, Ramalingam T, Mentink Kane M, Wilson M, El Kasmi K, Smith A, et al. Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog. 2009;5:e1000371 pubmed publisher
	Munder M, Eichmann K, Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol. 1998;160:5347-54 pubmed

product information

Product Type :

Antibody

Product Name :

Arginase 1 Monoclonal Antibody (sl6arg), eBioscience™

Catalog # :

14-9779-82

Quantity :

100µg

Price :

US 275

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry (Paraffin): 20 µg/mL, Western Blot: Assay-Dependent

Species :

Human

Clone :

sl6arg

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry (Paraffin): 20 µg/mL, Western Blot: Assay-Dependent

Aliases :

AI; A-I; AI type I arginase; AI256583; ARG1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; Arginase-1; BOS_9785; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; Type 1 Arginase; Type I arginase

more info or order :

Invitrogen product webpage