ZO-1 Monoclonal Antibody (R26.4C), eBioscience | Invitrogen 14-9776-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZO-1 Monoclonal Antibody (R26.4C), eBioscience

catalog :

14-9776-80

quantity :

25 ug

price :

US 177.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

R26.4C

The same clone is also sold as:

Developmental Studies Hybridoma Bank: R26.4C

reactivity :

mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 11

Reference
Scarpetta V, Bodaleo F, Salio C, Agarwal A, Sasso xe8 Pognetto M, Patrizi A. Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging. Fluids Barriers CNS. 2023;20:19 pubmed publisher
Sladky V, Akbari H, Tapias Gomez D, Evans L, Drown C, Strong M, et al. Centriole signaling restricts hepatocyte ploidy to maintain liver integrity. Genes Dev. 2022;36:843-56 pubmed publisher
LoMastro G, Drown C, Maryniak A, Jewett C, Strong M, HOLLAND A. PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells. elife. 2022;11: pubmed publisher
Aikawa S, Yuan J, Dewar A, Sun X, Dey S. Scribble promotes alveologenesis in the pregnant mammary gland for milk production. Reproduction. 2020;159:719-731 pubmed publisher
Wang D, Duan H, Feng J, Xiang J, Feng L, Liu D, et al. Soluble CD146, a cerebrospinal fluid marker for neuroinflammation, promotes blood-brain barrier dysfunction. Theranostics. 2020;10:231-246 pubmed publisher
Mercey O, Levine M, LoMastro G, Rostaing P, Brotslaw E, Gomez V, et al. Massive centriole production can occur in the absence of deuterosomes in multiciliated cells. Nat Cell Biol. 2019;21:1544-1552 pubmed publisher
Nakamura S, Irie K, Tanaka H, Nishikawa K, Suzuki H, Saitoh Y, et al. Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun. 2019;10:816 pubmed publisher
Qiao S, Qian Y, Xu G, Luo Q, Zhang Z. Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging. J Neuroinflammation. 2019;16:4 pubmed publisher
Zhang Y, Zhao D, Yang S, Yao H, Li M, Zhao C, et al. Protective Effects of Fucoidan on Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells and Progression of Proliferative Vitreoretinopathy. Cell Physiol Biochem. 2018;46:1704-1715 pubmed publisher
Wittchen E, Haskins J, Stevenson B. Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J Biol Chem. 1999;274:35179-85 pubmed
Stevenson B, Siliciano J, Mooseker M, Goodenough D. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol. 1986;103:755-66 pubmed

product information

Product Type :

Antibody

Product Name :

ZO-1 Monoclonal Antibody (R26.4C), eBioscience

Catalog # :

14-9776-80

Quantity :

25 ug

Price :

US 177.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Canine, Mouse, Rat

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 10 ug/mL, Western Blot: Assay-Dependent

Species :

Canine, Mouse, Rat

Clone :

R26.4C

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 10 ug/mL, Western Blot: Assay-Dependent

Aliases :

DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1