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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD4 Monoclonal Antibody (4SM95), eBioscience™
catalog :
14-9766-82
quantity :
100µg
price :
US 275
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
4SM95
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 37
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5e
von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s4
Sato Y, Bolzenius J, Eteleeb A, Su X, Maher C, Sehn J, et al. CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blockade. JCI Insight. 2018;3: pubmed publisher
  • immunohistochemistry; mouse; 1:40; loading ...; fig 5a
Kanneganti A, Malireddi R, Saavedra P, Vande Walle L, Van Gorp H, Kambara H, et al. GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever. J Exp Med. 2018;215:1519-1529 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Rickelt S, Hynes R. Antibodies and methods for immunohistochemistry of extracellular matrix proteins. Matrix Biol. 2018;71-72:10-27 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5c
Ubil E, Caskey L, Holtzhausen A, Hunter D, Story C, Earp H. Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest. 2018;128:2356-2369 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:600; loading ...; fig s11e
Zhang Z, Zi Z, Lee E, Zhao J, Contreras D, South A, et al. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med. 2018;24:617-627 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s7b
Pishesha N, Bilate A, Wibowo M, Huang N, Li Z, Deshycka R, et al. Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease. Proc Natl Acad Sci U S A. 2017;114:3157-3162 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; fig 3
Liu Y, Wang Z, De La Torre R, Barling A, Tsujikawa T, Hornick N, et al. Trim32 Deficiency Enhances Th2 Immunity and Predisposes to Features of Atopic Dermatitis. J Invest Dermatol. 2017;137:359-366 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:20; loading ...; fig 3b
Hirai Yuki A, Hensley L, McGivern D, Gonzalez Lopez O, Das A, Feng H, et al. MAVS-dependent host species range and pathogenicity of human hepatitis A virus. Science. 2016;353:1541-1545 pubmed
  • immunohistochemistry; mouse; fig 3
Seo J, Bang M, Kim G, Cho S, Park D. Erythronium japonicum attenuates histopathological lung abnormalities in a mouse model of ovalbumin-induced asthma. Int J Mol Med. 2016;37:1221-8 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 10
Marek I, Lichtneger T, Cordasic N, Hilgers K, Volkert G, Fahlbusch F, et al. Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover. PLoS ONE. 2016;11:e0150471 pubmed publisher
  • immunohistochemistry; mouse; fig 5
Bang M, Seo J, Seo J, Jo G, Jung S, Yu R, et al. Bacillus subtilis KCTC 11782BP-produced alginate oligosaccharide effectively suppresses asthma via T-helper cell type 2-related cytokines. PLoS ONE. 2015;10:e0117524 pubmed publisher
  • immunocytochemistry; mouse
Hirayama T, Asano Y, Iida H, Watanabe T, Nakamura T, Goitsuka R. Meis1 is required for the maintenance of postnatal thymic epithelial cells. PLoS ONE. 2014;9:e89885 pubmed publisher
Morrison M, Verschuren L, Salic K, Verheij J, Menke A, Wielinga P, et al. Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice. Hepatol Commun. 2018;2:1513-1532 pubmed publisher
Simula L, Pacella I, Colamatteo A, Procaccini C, Cancila V, Bordi M, et al. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming. Cell Rep. 2018;25:3059-3073.e10 pubmed publisher
Messenger Z, Hall J, Jima D, House J, Tam H, Tokarz D, et al. C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event. Cell Death Dis. 2018;9:1054 pubmed publisher
Mi Y, Smith C, Yang F, Qi Y, Roche K, Serody J, et al. A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy. Adv Mater. 2018;30:e1706098 pubmed publisher
Suárez López L, Sriram G, Kong Y, Morandell S, Merrick K, Hernandez Y, et al. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Proc Natl Acad Sci U S A. 2018;115:E4236-E4244 pubmed publisher
May S, Owen H, Phesse T, Greenow K, Jones G, Blackwood A, et al. Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. J Pathol. 2018;245:270-282 pubmed publisher
Luo N, Nixon M, Gonzalez Ericsson P, Sanchez V, Opalenik S, Li H, et al. DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer. Nat Commun. 2018;9:248 pubmed publisher
Kwak J, Laskowski J, Li H, McSharry M, Sippel T, Bullock B, et al. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018;78:143-156 pubmed publisher
Yan X, Wang L, Zhang R, Pu X, Wu S, Yu L, et al. Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy. Oncoimmunology. 2017;7:e1376156 pubmed publisher
Tani C, Vagnani S, Carli L, Querci F, Kuhl A, Spieckermann S, et al. Treatment with Allogenic Mesenchymal Stromal Cells in a Murine Model of Systemic Lupus Erythematosus. Int J Stem Cells. 2017;10:160-168 pubmed publisher
Unver N, Delgado O, Zeleke K, Cumpian A, Tang X, Caetano M, et al. Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol. Int J Cancer. 2017;: pubmed publisher
Lee S, Bae C, Seo J, Cho S, Bae M, Oh D, et al. Mycoleptodonoides aitchisonii suppresses asthma via Th2 and Th1 cell regulation in an ovalbumin?induced asthma mouse model. Mol Med Rep. 2017;: pubmed publisher
Beigier Bompadre M, Montagna G, Kuhl A, Lozza L, Weiner J, Kupz A, et al. Mycobacterium tuberculosis infection modulates adipose tissue biology. PLoS Pathog. 2017;13:e1006676 pubmed publisher
Schmid P, Bouazzaoui A, Schmid K, Birner C, Schach C, Maier L, et al. Acute Renal Graft-Versus-Host Disease in a Murine Model of Allogeneic Bone Marrow Transplantation. Cell Transplant. 2017;26:1428-1440 pubmed publisher
Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw A, et al. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017;127:3136-3151 pubmed publisher
Jaini R, Loya M, Eng C. Immunotherapeutic target expression on breast tumors can be amplified by hormone receptor antagonism: a novel strategy for enhancing efficacy of targeted immunotherapy. Oncotarget. 2017;8:32536-32549 pubmed publisher
Jin Z, Liang F, Yang J, Mei W. hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer. PLoS Genet. 2017;13:e1006672 pubmed publisher
Lhotak S, Gyulay G, Cutz J, Al Hashimi A, Trigatti B, Richards C, et al. Characterization of Proliferating Lesion-Resident Cells During All Stages of Atherosclerotic Growth. J Am Heart Assoc. 2016;5: pubmed publisher
Kroon P, Gadiot J, Peeters M, Gasparini A, Deken M, Yagita H, et al. Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma. Cancer Immunol Immunother. 2016;65:753-63 pubmed publisher
Xiao J, Lu Z, Sheng J, Song Y, Jiang W, Liu F, et al. 5-fluorouracil attenuates dextran sodium sulfate-induced acute colitis in mice. Mol Med Rep. 2016;13:2821-8 pubmed publisher
Wang D, Mou H, Li S, Li Y, Hough S, Tran K, et al. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Hum Gene Ther. 2015;26:432-42 pubmed publisher
Foti M, Phelouzat M, Holm A, Rasmusson B, Carpentier J. p56Lck anchors CD4 to distinct microdomains on microvilli. Proc Natl Acad Sci U S A. 2002;99:2008-13 pubmed
Dialynas D, Quan Z, Wall K, Pierres A, Quintans J, Loken M, et al. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J Immunol. 1983;131:2445-51 pubmed
Wilde D, Marrack P, Kappler J, Dialynas D, Fitch F. Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. J Immunol. 1983;131:2178-83 pubmed
product information
Product Type :
Antibody
Product Name :
CD4 Monoclonal Antibody (4SM95), eBioscience™
Catalog # :
14-9766-82
Quantity :
100µg
Price :
US 275
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 5 µg/mL
Species :
Mouse
Clone :
4SM95
Isotype :
IgG1, kappa
Storage :
4° C
Description :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 5 µg/mL
Aliases :
BOS_5959; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 receptor; cd4a; CD4mut; cell surface glycoprotein CD4; fCD4; L3T4; Leu-3; Ly-4; lymphocyte antigen CD4; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); W3/25; W3/25 antigen
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA