ITK Monoclonal Antibody (2F12), eBioscience | Invitrogen 14-9752-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ITK Monoclonal Antibody (2F12), eBioscience

catalog :

14-9752-82

quantity :

100 ug

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2F12

The same clone is also sold as:

Santa Cruz Biotechnology: sc-23902 HRP, sc-23902, sc-23902 AC
BD Biosciences: 550503
Cell Signaling Technology: 2380

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 3

Reference
August A, Ragin M. Regulation of T-cell responses and disease by tec kinase Itk. Int Rev Immunol. 2012;31:155-65 pubmed publisher
Huck K, Feyen O, Niehues T, Ruschendorf F, Hubner N, Laws H, et al. Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest. 2009;119:1350-8 pubmed
Atherly L, Lucas J, Felices M, Yin C, Reiner S, Berg L. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity. 2006;25:79-91 pubmed

product information

Product Type :

Antibody

Product Name :

ITK Monoclonal Antibody (2F12), eBioscience

Catalog # :

14-9752-82

Quantity :

100 ug

Price :

US 451.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1 ug/mL, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Clone :

2F12

Isotype :

IgG1, kappa

Storage :

4 C

Description :

ITK is a tyrosine kinase expressed in T-cells which contains both SH2 and SH3 domains. ITK is thought to play a role in T-cell proliferation and differentiation. The Tec family of non-receptor tyrosine kinases is composed of six proteins designated Tec, Itk (also known as Emt or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain pleckstrin homology (PH) and Tec homology (TH) domains in their amino termini. Itk associates with CD28 and becomes activated subsequent to CD28 ligation.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1 ug/mL, Western Blot: 1:1,000

Aliases :

EMT; homolog of mouse T-cell itk/tsk; IL2 inducible T cell kinase; IL2 inducible T-cell kinase; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; ITK; Kinase EMT; kinase TLK; LPFS1; LYK; MGC126257; MGC126258; PSCTK2; T-cell-specific kinase; Tcsk; Tlk; Tsk; Tyrosine-protein kinase ITK/TSK; tyrosine-protein kinase LYK