IDO Monoclonal Antibody (V1NC3IDO), eBioscience | Invitrogen 14-9750-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IDO Monoclonal Antibody (V1NC3IDO), eBioscience

catalog :

14-9750-82

quantity :

100 ug

price :

US 345.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

V1NC3IDO

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 6

Reference
Kjeldsen J, Lorentzen C, Martinenaite E, Ellebaek E, Donia M, Holmstroem R, et al. A phase 1/2 trial of an immune-modulatory vaccine against IDO/PD-L1 in combination with nivolumab in metastatic melanoma. Nat Med. 2021;27:2212-2223 pubmed publisher
Duffield A, Ascierto M, Anders R, Taube J, Meeker A, Chen S, et al. Th17 immune microenvironment in Epstein-Barr virus-negative Hodgkin lymphoma: implications for immunotherapy. Blood Adv. 2017;1:1324-1334 pubmed publisher
Curti A, Trabanelli S, Salvestrini V, Baccarani M, Lemoli R. The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology. Blood. 2009;113:2394-401 pubmed publisher
Chen W, Liang X, Peterson A, Munn D, Blazar B. The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. J Immunol. 2008;181:5396-404 pubmed
Nakamura T, Shima T, Saeki A, Hidaka T, Nakashima A, Takikawa O, et al. Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer. Cancer Sci. 2007;98:874-81 pubmed
Takikawa O, Kuroiwa T, Yamazaki F, Kido R. Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity. J Biol Chem. 1988;263:2041-8 pubmed

product information

Product Type :

Antibody

Product Name :

IDO Monoclonal Antibody (V1NC3IDO), eBioscience

Catalog # :

14-9750-82

Quantity :

100 ug

Price :

US 345.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 0.5 ug/mL, Western Blot: 1:1,000

Species :

Human

Clone :

V1NC3IDO

Isotype :

IgG2b, kappa

Storage :

4 C

Description :

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 0.5 ug/mL, Western Blot: 1:1,000

Aliases :

EC 1.13.11.52; IDO; IDO1; IDO-1; INDO; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine; indoleamine 2,3-dioxygenase 1; indoleamine 23-dioxygenase; Indoleamine-2; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase