APP (Amyloid Precursor Protein) Monoclonal Antibody (22C11), eBioscience | Invitrogen 14-9749-37 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

APP (Amyloid Precursor Protein) Monoclonal Antibody (22C11), eBioscience

catalog :

14-9749-37

quantity :

2 mg

price :

US 1474.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

22C11

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:5000; loading ...; fig s4b	Marengo L, Armbrust F, Schoenherr C, Storck S, Schmitt U, Zampar S, et al. Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease. Cell Mol Life Sci. 2022;79:168 pubmed publisher
	Lee W, Lee H, Yang J, Shin H, Choi S, Kim J, et al. The Potential Neuroprotective Effects of Extracts from Oat Seedlings against Alzheimer's Disease. Nutrients. 2022;14: pubmed publisher
	Wang X, Shi Q, Pradhan A, Ziegon L, Schlegel M, Rammes G. Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss. Int J Mol Sci. 2022;23: pubmed publisher
	Tallino S, Winslow W, Bartholomew S, Velázquez R. Temporal and brain region-specific elevations of soluble Amyloid-β40-42 in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease. Aging Cell. 2022;21:e13590 pubmed publisher
	Kleffman K, Levinson G, Rose I, Blumenberg L, Shadaloey S, Dhabaria A, et al. Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis. Cancer Discov. 2022;12:1314-1335 pubmed publisher
	Jord xe0 Siquier T, Petrel M, Kouskoff V, Smailovic U, Cordeli xe8 res F, Frykman S, et al. APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?. Alzheimers Dement. 2022;18:2099-2116 pubmed publisher
	Hu Y, Zhang Y, Ren R, Dammer E, Xie X, Chen S, et al. microRNA-425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies. Aging Cell. 2021;20:e13454 pubmed publisher
	Xu P, Chang J, Zhou X, Wang W, Bamkole M, Wong E, et al. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. J Exp Med. 2021;218: pubmed publisher
	Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis M, Liu C, et al. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nat Commun. 2020;11:5540 pubmed publisher
	Knupp A, Mishra S, Martinez R, Braggin J, Szabó M, Kinoshita C, et al. Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing. Cell Rep. 2020;31:107719 pubmed publisher
	Hui L, Soliman M, Geiger N, Miller N, Afghah Z, Lakpa K, et al. Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis. J Alzheimers Dis. 2019;67:393-410 pubmed publisher
	Chapuis J, Flaig A, Grenier Boley B, Eysert F, Pottiez V, Deloison G, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathol. 2017;133:955-966 pubmed publisher

product information

Product Type :

Antibody

Product Name :

APP (Amyloid Precursor Protein) Monoclonal Antibody (22C11), eBioscience

Catalog # :

14-9749-37

Quantity :

2 mg

Price :

US 1474.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 2.5 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 2 ug/mL

Species :

Human, Mouse, Rat

Clone :

22C11

Isotype :

IgG1, kappa

Storage :

4 C

Description :

Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer's disease. Abnormal regulation and processing of APP also plays a role in Down's syndrome, early onset familial Alzheimer's disease, and cerebral hemorrhage.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2.5 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 2 ug/mL

Aliases :

A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid A4; Amyloid b precursor protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid ß precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2

more info or order :

Invitrogen product webpage