Glucagon Monoclonal Antibody (ICACLS), eBioscience | Invitrogen 14-9743-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Glucagon Monoclonal Antibody (ICACLS), eBioscience

catalog :

14-9743-80

quantity :

25 ug

price :

US 177.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ICACLS

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunohistochemistry - paraffin section

citations: 8

Reference
Chen H, Liu J, Shi G, Zhang X. Protocol for in vivo and ex vivo assessment of hyperglycemia and islet function in diabetic mice. STAR Protoc. 2023;4:102133 pubmed publisher
Zhang X, Luo S, Wang M, Huang Q, Fang W, Li J, et al. IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells. Dev Cell. 2022;57:1496-1511.e6 pubmed publisher
Norman D, Drott C, Carlsson P, Espes D. Irisin-A Pancreatic Islet Hormone. Biomedicines. 2022;10: pubmed publisher
Liu Z, Ding Z, Lynch E, McCauley N, Zhou Y, Zhang K, et al. Pregestational diet transition to normal-fat diet avoids the deterioration of pancreatic β-cell function in male offspring induced by maternal high-fat diet. J Nutr Biochem. 2020;86:108495 pubmed publisher
Kaptaner B. Immunohistochemical distribution of insulin-, glucagon- and somatostatin-containing cells in the pancreas of Lake Van fish (Alburnus tarichi Güldenstädt, 1814) (Cyprinidae). Eur J Histochem. 2019;63: pubmed publisher
Taborsky G. The physiology of glucagon. J Diabetes Sci Technol. 2010;4:1338-44 pubmed
Sloop K, Michael M, Moyers J. Glucagon as a target for the treatment of Type 2 diabetes. Expert Opin Ther Targets. 2005;9:593-600 pubmed
Jiang G, Zhang B. Glucagon and regulation of glucose metabolism. Am J Physiol Endocrinol Metab. 2003;284:E671-8 pubmed

product information

Product Type :

Antibody

Product Name :

Glucagon Monoclonal Antibody (ICACLS), eBioscience

Catalog # :

14-9743-80

Quantity :

25 ug

Price :

US 177.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 0.1 ug/mL

Species :

Human, Mouse, Rat

Clone :

ICACLS

Isotype :

IgG1, kappa

Storage :

4 C

Description :

Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus. The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogensis, which are antagonistic effects to those of insulin action, thus leading to increased blood glucose levels. Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15-20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets. Pathological manifestations of the glucagon-type peptide residue almost exclusively with the exsistence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified. Glucagon-specific antibodies would prove useful as a cell and tumor markers applying immunohistochemical techniques, and as an analytical tool in qualification of the hormone.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 0.1 ug/mL

Aliases :

GCG; Glicentin; Glicentin-related polypeptide; GLP1; GLP-1; GLP-1(7-36); GLP-1(7-37); GLP1/2; GLP2; GLP-2; Glu; glucagon; Glucagon-like peptide 1; Glucagon-like peptide 1(7-36); Glucagon-like peptide 1(7-37); Glucagon-like peptide 2; glucagon-like peptide-1; GRPP; IL12p35; IL12P40; Incretin hormone; OXM; OXY; Oxyntomodulin; porcine proglucagon; PPG; preproglucagon; proglucagon