Globo H Monoclonal Antibody (VK9), eBioscience | Invitrogen 14-9700-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Globo H Monoclonal Antibody (VK9), eBioscience

catalog :

14-9700-82

quantity :

100 ug

price :

US 487.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

VK9

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 4

Reference
Liang Y, Yang B, Chen J, Lin Y, Huang C, Cheng Y, et al. Changes in glycosphingolipid composition during differentiation of human embryonic stem cells to ectodermal or endodermal lineages. Stem Cells. 2011;29:1995-2004 pubmed publisher
Wang C, Huang Y, Ren C, Lin C, Hung J, Yu J, et al. Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer. Proc Natl Acad Sci U S A. 2008;105:11661-6 pubmed publisher
Chang W, Lee C, Lee P, Lin J, Hsu C, Hung J, et al. Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis. Proc Natl Acad Sci U S A. 2008;105:11667-72 pubmed publisher
Kudryashov V, Ragupathi G, Kim I, Breimer M, Danishefsky S, Livingston P, et al. Characterization of a mouse monoclonal IgG3 antibody to the tumor-associated globo H structure produced by immunization with a synthetic glycoconjugate. Glycoconj J. 1998;15:243-9 pubmed

product information

Product Type :

Antibody

Product Name :

Globo H Monoclonal Antibody (VK9), eBioscience

Catalog # :

14-9700-82

Quantity :

100 ug

Price :

US 487.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 5 ug/mL

Species :

Human

Clone :

VK9

Isotype :

IgG3, kappa

Storage :

4 C

Description :

Globo H is a hexasaccharide formed from the pentasaccharide precursor, SSEA3 (stage-specific embryonic antigen 3). It is a member of a family of antigenic carbohydrates expressed on the surface of cancer cells as glycolipids and possibly glycoproteins. Globo H is overexpressed on many carcinomas, such as breast, colon, ovarian, gastric, pancreatic, lung, and prostate. Expression is observed in more than half of all ductal, lobular, and tubular breast carcinomas, but not in non-epithelial breast tumors. Globo H is also expressed on cancer stem cells and human embryonic stem cells, although expression decreases when cells are differentiated toward both neural progenitor cells and to a lesser extent in endodermal lineage cells. Expression in normal tissues is limited to cells composing secretory borders. Globo H is considered a target for immunotherapy of many epithelial cancers.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 5 ug/mL

Aliases :

Globo H antigen; globoH; Globohexaosylceramide