Lamin A/C Monoclonal Antibody (4A7), eBioscience | Invitrogen 14-9688-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Lamin A/C Monoclonal Antibody (4A7), eBioscience

catalog :

14-9688-80

quantity :

25 ug

price :

US 166.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4A7

reactivity :

Chinese hamsters, human, mouse, domestic rabbit

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 5

Reference
Shah S, Molinaro G, Liu B, Wang R, Huber K, Richter J. FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism. Cell Rep. 2020;30:4459-4472.e6 pubmed publisher
Zuela N, Bar D, Gruenbaum Y. Lamins in development, tissue maintenance and stress. EMBO Rep. 2012;13:1070-8 pubmed publisher
Jung H, Lee J, Yang S, Young S, Fong L. Nuclear lamins in the brain - new insights into function and regulation. Mol Neurobiol. 2013;47:290-301 pubmed publisher
Navarro C, De Sandre Giovannoli A, Bernard R, Boccaccio I, Boyer A, Genevieve D, et al. Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy. Hum Mol Genet. 2004;13:2493-503 pubmed
Manilal S, Randles K, Aunac C, Nguyen M, Morris G. A lamin A/C beta-strand containing the site of lipodystrophy mutations is a major surface epitope for a new panel of monoclonal antibodies. Biochim Biophys Acta. 2004;1671:87-92 pubmed

product information

Product Type :

Antibody

Product Name :

Lamin A/C Monoclonal Antibody (4A7), eBioscience

Catalog # :

14-9688-80

Quantity :

25 ug

Price :

US 166.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Hamster, Human, Mouse, Rabbit

Applications :

ELISA: Assay-dependent, Flow Cytometry: 10 ug/mL, Immunocytochemistry: 10 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent

Species :

Hamster, Human, Mouse, Rabbit

Clone :

4A7

Isotype :

IgG1, kappa

Storage :

4 C

Description :

Lamins are a class of intermediate filament proteins that form a matrix on the inner surface of the nuclear envelope. These proteins are found in many different cell types in three different forms (A, B, and C). Lamins A and C are alternatively spliced versions of the LMNA gene. The LMNA gene has been linked to many disorders of the muscular system, nervous system, and the fat distributions systems including: Emery-Dreifuss muscular dystrophy, Dunnigan-type familial partial lipodystrophy (FPLD), limb-girdle muscular dystrophy (LGMD1B), dilated cardiomyopathy (CMD1A), axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1), and mandibuloacral dysplasia (MAD).

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: 10 ug/mL, Immunocytochemistry: 10 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent

Aliases :

70 kDa lamin; cb948; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; I79_009616; IDC; lamin; lamin A; lamin A/C; lamin A/C L homeolog; lamin A/C-like 1; Lamin A+C mutant; Lamin AC; lamin a-c; lamin C; lamin C2; lamin-A; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; lmna; LMNA protein; lmna.L; lmna-A; LMNC; LMNL1; mutant 453W; Mutant lamin A/C; nuclear intermediate filament protein; nuclear lamin A; prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32; RP11-54H19.1; unnamed protein product; wu:fk66d12; XELAEV_18040808mg