AIRE Monoclonal Antibody (TM-724), eBioscience | Invitrogen 14-9534-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

AIRE Monoclonal Antibody (TM-724), eBioscience

catalog :

14-9534-82

quantity :

100 µg

price :

US 300.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

TM-724

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; human; fig s2	Buerger S, Herrmann V, Mundt S, Trautwein N, Groettrup M, Basler M. The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection. J Immunol. 2015;195:4106-16 pubmed publisher
	Bianchi F, Sommariva M, De Cecco L, Triulzi T, Romero Córdoba S, Tagliabue E, et al. Expression and prognostic significance of the autoimmune regulator gene in breast cancer cells. Cell Cycle. 2016;15:3220-3229 pubmed
	Glimcher L, Martinon F, Modlin R. Editorial overview. Curr Opin Immunol. 2011;23:1-2 pubmed publisher
	Poliani P, Kisand K, Marrella V, Ravanini M, Notarangelo L, Villa A, et al. Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells. Am J Pathol. 2010;176:1104-12 pubmed publisher
	Suzuki E, Kobayashi Y, Kawano O, Endo K, Haneda H, Yukiue H, et al. Expression of AIRE in thymocytes and peripheral lymphocytes. Autoimmunity. 2008;41:133-9 pubmed publisher

product information

Product Type :

Antibody

Product Name :

AIRE Monoclonal Antibody (TM-724), eBioscience

Catalog # :

14-9534-82

Quantity :

100 µg

Price :

US 300.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human

Applications :

Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL

Species :

Human

Clone :

TM-724

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL

Aliases :

Aire; AIRE protein; AIRE1; APECED; APECED protein; APECED protein homolog; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; LOW QUALITY PROTEIN: autoimmune regulator; OTTHUMP00000109529; PGA1

more info or order :

Invitrogen product webpage