CD326 (EpCAM) Monoclonal Antibody (1B7), eBioscience | Invitrogen 14-9326-95 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD326 (EpCAM) Monoclonal Antibody (1B7), eBioscience

catalog :

14-9326-95

quantity :

10 mg

price :

US 3705.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1B7

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 31

Reference
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Li L, Zhou Y, Zhang Y, Hu H, Mao H, Selaru F. A combination therapy of bortezomib, CXCR4 inhibitor, and checkpoint inhibitor is effective in cholangiocarcinoma in vivo. iScience. 2023;26:106095 pubmed publisher
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Doerfler R, Melamed J, Whitehead K. The Effect of Infant Gastric Digestion on Human Maternal Milk Cells. Mol Nutr Food Res. 2022;66:e2200090 pubmed publisher
Li J, Camirand A, Zakikhani M, Sellin K, Guo Y, Luan X, et al. Parathyroid Hormone-Related Protein Inhibition Blocks Triple-Negative Breast Cancer Expansion in Bone Through Epithelial to Mesenchymal Transition Reversal. JBMR Plus. 2022;6:e10587 pubmed publisher
Prater A, Deutscher S. Selection of Cancer Stem Cell-Targeting Agents Using Bacteriophage Display. Methods Mol Biol. 2022;2394:787-810 pubmed publisher
Rana N, Privitera G, Kondolf H, Bulek K, Lechuga S, De Salvo C, et al. GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis. Cell. 2022;185:283-298.e17 pubmed publisher
Hirai H, Liang X, Sun Y, Zhang Y, Zhang J, Chen Y, et al. The sodium/glucose cotransporters as potential therapeutic targets for CF lung diseases revealed by human lung organoid swelling assay. Mol Ther Methods Clin Dev. 2022;24:11-19 pubmed publisher
Zhou K, Sun Y, Dong D, Zhao C, Wang W. EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties. Cell Death Dis. 2021;12:844 pubmed publisher
Alfi O, Yakirevitch A, Wald O, Wandel O, Izhar U, Oiknine Djian E, et al. Human Nasal and Lung Tissues Infected Ex Vivo with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract. J Virol. 2021;95:e0013021 pubmed publisher
Sun Y, Wang Z, Na L, Dong D, Wang W, Zhao C. FZD5 contributes to TNBC proliferation, DNA damage repair and stemness. Cell Death Dis. 2020;11:1060 pubmed publisher
Feng G, Chen Y, Li K. Helicobacter pylori promote inflammation and host defense through the cagA-dependent activation of mTORC1. J Cell Physiol. 2020;235:10094-10108 pubmed publisher
Li X, Strietz J, Bleilevens A, Stickeler E, Maurer J. Chemotherapeutic Stress Influences Epithelial-Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer. Int J Mol Sci. 2020;21: pubmed publisher
Jenkins S, Nima Z, Vang K, Kannarpady G, Nedosekin D, Zharov V, et al. Triple-negative breast cancer targeting and killing by EpCAM-directed, plasmonically active nanodrug systems. NPJ Precis Oncol. 2017;1:27 pubmed publisher
Nguyen Q, Pervolarakis N, Blake K, Ma D, Davis R, James N, et al. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018;9:2028 pubmed publisher
Huang S, Wei P, Hwang Verslues W, Kuo W, Jeng Y, Hu C, et al. TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB. EMBO Mol Med. 2017;9:1660-1680 pubmed publisher
Pode Shakked N, Gershon R, Tam G, Omer D, Gnatek Y, Kanter I, et al. Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level. Stem Cell Reports. 2017;9:279-291 pubmed publisher
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Cheung S, Chuang P, Huang H, Hwang Verslues W, Cho C, Yang W, et al. Stage-specific embryonic antigen-3 (SSEA-3) and Î²3GalT5 are cancer specific and significant markers for breast cancer stem cells. Proc Natl Acad Sci U S A. 2016;113:960-5 pubmed publisher
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product information

Product Type :

Antibody

Product Name :

CD326 (EpCAM) Monoclonal Antibody (1B7), eBioscience

Catalog # :

14-9326-95

Quantity :

10 mg

Price :

US 3705.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.25 ug/test, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Frozen): 10 ug/mL, Immunohistochemistry (Paraffin): 10 ug/mL, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent

Species :

Human

Clone :

1B7

Isotype :

IgG1, kappa

Storage :

4 C

Description :

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.

Format :

Liquid

Applications w/Dilutions :

Aliases :

adenocarcinoma-associated antigen; CD326; cell surface glycoprotein Trop-1; DIAR5; EGP; EGP-2; EGP314; EGP40; EPCAM; Ep-CAM; EpCAM1; epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; gp40; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; Ly74; lymphocyte antigen 74; M1S2; M4S1; major gastrointestinal tumor-associated protein GA733-2; mEGP314; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; panepithelial glycoprotein 314; protein 289A; Protein D5.7A; Tacsd1; Tacstd1; TROP1; Trop-1 protein; Tumor-associated calcium signal transducer 1