PSA-NCAM Monoclonal Antibody (12E3), eBioscience | Invitrogen 14-9118-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PSA-NCAM Monoclonal Antibody (12E3), eBioscience

catalog :

14-9118-80

quantity :

25 ug

price :

US 187.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1.20E+04

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 13

Reference
Sucha M, Benediktova S, Tichanek F, Jedlicka J, Kapl S, Jelinkova D, et al. Experimental Treatment with Edaravone in a Mouse Model of Spinocerebellar Ataxia 1. Int J Mol Sci. 2023;24: pubmed publisher
El Waly B, Bertet C, Paris M, Falque M, Milpied P, Magalon K, et al. Neuroblasts contribute to oligodendrocytes generation upon demyelination in the adult mouse brain. iScience. 2022;25:105102 pubmed publisher
Trinh V, Roland J, Wong J, Revetta F, Patel K, Shi C, et al. Peak density of immature nerve cells occurs with high-grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas. J Pathol. 2022;258:69-82 pubmed publisher
García González D, Dumitru I, Zuccotti A, Yen T, Herranz Pérez V, Tan L, et al. Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain. Mol Psychiatry. 2020;: pubmed publisher
Polis B, Srikanth K, Gurevich V, Bloch N, Gil Henn H, Samson A. Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer's Disease Mice. Int J Mol Sci. 2020;21: pubmed publisher
Nakano M, Mishra S, Tokoro Y, Sato K, Nakajima K, Yamaguchi Y, et al. Bisecting GlcNAc Is a General Suppressor of Terminal Modification of N-glycan. Mol Cell Proteomics. 2019;18:2044-2057 pubmed publisher
Xiao L, Saiki C, Okamura H. Oxidative Stress-Tolerant Stem Cells from Human Exfoliated Deciduous Teeth Decrease Hydrogen Peroxide-Induced Damage in Organotypic Brain Slice Cultures from Adult Mice. Int J Mol Sci. 2019;20: pubmed publisher
Xiao L, Ide R, Saiki C, Kumazawa Y, Okamura H. Human Dental Pulp Cells Differentiate toward Neuronal Cells and Promote Neuroregeneration in Adult Organotypic Hippocampal Slices In Vitro. Int J Mol Sci. 2017;18: pubmed publisher
García González D, Khodosevich K, Watanabe Y, Rollenhagen A, Lübke J, Monyer H. Serotonergic Projections Govern Postnatal Neuroblast Migration. Neuron. 2017;94:534-549.e9 pubmed publisher
Espinosa A, Gil Sanz C, Yanagawa Y, Fairen A. Two separate subtypes of early non-subplate projection neurons in the developing cerebral cortex of rodents. Front Neuroanat. 2009;3:27 pubmed publisher
Wakayama T, Tabar V, Rodriguez I, Perry A, Studer L, Mombaerts P. Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Science. 2001;292:740-3 pubmed
Seki T, Rutishauser U. Removal of polysialic acid-neural cell adhesion molecule induces aberrant mossy fiber innervation and ectopic synaptogenesis in the hippocampus. J Neurosci. 1998;18:3757-66 pubmed
Seki T, Arai Y. Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat. J Neurosci. 1993;13:2351-8 pubmed

product information

Product Type :

Antibody

Product Name :

PSA-NCAM Monoclonal Antibody (12E3), eBioscience

Catalog # :

14-9118-80

Quantity :

25 ug

Price :

US 187.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 20 ug/mL, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1:500

Species :

Human, Mouse, Rat

Clone :

1.20E+04

Isotype :

IgM

Storage :

4 C

Description :

Polysialic acid is a long homopolymer of sialic acid that is negatively charged and is attached to neural cell adhesion molecule (CD56) and serves as a regulator of NCAM function. PSA attachment to NCAM is associated with inhibited adhesion of neural cells. PSA-NCAM expression is highly regulated and corresponds to specific neural developmental windows in which neural precursors are migrating and during the process of axonal sprouting, guidance, and targeting. PSA-NCAM expression is prevalent during development of the brain, but in the adult becomes restricted to regions undergoing self-renewal or exhibiting plasticity such as the olfactory bulb, suprachiasmatic nucleus, hippocampus, hypothalamus, and specific spinal cord nuclei. PSA-NCAM is re-expressed during tumorigenesis and is also expressed on cell lines isolated from neuroblastomas and pheochromocytomas.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 20 ug/mL, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1:500

Aliases :

antigen recognized by monoclonal antibody 5.1H11; CD56; E-NCAM; MSK39; Ncam; N-CAM; NCAM1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; Polysialylated NCAM; PSA NCAM