product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD289 (TLR9) Monoclonal Antibody (eB72-1665), eBioscience™
catalog :
14-9099-82
quantity :
100 µg
price :
279 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
eB72-1665
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 37
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 1d
Deeba E, Lambrianides A, Pantzaris M, Krashias G, Christodoulou C. The expression profile of virus-recognizing toll-like receptors in natural killer cells of Cypriot multiple sclerosis patients. BMC Res Notes. 2020;13:460 pubmed publisher
  • flow cytometry; human; fig 1
Mitterreiter J, Ouwendijk W, van Velzen M, van Nierop G, Osterhaus A, Verjans G. Satellite glial cells in human trigeminal ganglia have a broad expression of functional Toll-like receptors. Eur J Immunol. 2017;47:1181-1187 pubmed publisher
  • flow cytometry; human; loading ...; fig 5a
Nagase H, Takeoka T, Urakawa S, Morimoto Okazawa A, Kawashima A, Iwahori K, et al. ICOS+ Foxp3+ TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori. Int J Cancer. 2017;140:686-695 pubmed publisher
  • flow cytometry; human; fig 8
Babu R, Brown A. A consensus surface activation marker signature is partially dependent on human immunodeficiency virus type 1 Nef expression within productively infected macrophages. Retrovirology. 2013;10:155 pubmed publisher
  • immunocytochemistry; human; fig 6
Latz E, Schoenemeyer A, Visintin A, Fitzgerald K, Monks B, Knetter C, et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol. 2004;5:190-8 pubmed
Moreno R, Fajardo C, Farrera Sal M, Perisé Barrios A, Morales Molina Á, Al Zaher A, et al. Enhanced Antitumor Efficacy of Oncolytic Adenovirus-loaded Menstrual Blood-derived Mesenchymal Stem Cells in Combination with Peripheral Blood Mononuclear Cells. Mol Cancer Ther. 2019;18:127-138 pubmed publisher
Aillot L, Bonnin M, Ait Goughoulte M, Bendriss Vermare N, Maadadi S, Dimier L, et al. Interaction between Toll-Like Receptor 9-CpG Oligodeoxynucleotides and Hepatitis B Virus Virions Leads to Entry Inhibition in Hepatocytes and Reduction of Alpha Interferon Production by Plasmacytoid Dendritic Cells. Antimicrob Agents Chemother. 2018;62: pubmed publisher
Tobouti P, BOLT R, Radhakrishnan R, de Sousa S, Hunter K. Altered Toll-like receptor expression and function in HPV-associated oropharyngeal carcinoma. Oncotarget. 2018;9:236-248 pubmed publisher
Zhang F, Wang D, Chen F. Toll-like receptor-9 in hypoxic nasopharyngeal carcinoma cells and its correlation with cell proliferation and apoptosis. Oncol Lett. 2017;14:7829-7832 pubmed publisher
Chauhan A. Fc?RIIIa Signaling Modulates Endosomal TLR Responses in Human CD4+ T Cells. J Immunol. 2017;198:4596-4606 pubmed publisher
Zheng Y, Qin Z, Ye Q, Chen P, Wang Z, Yan Q, et al. Lactoferrin suppresses the Epstein-Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9. Lab Invest. 2014;94:1188-99 pubmed publisher
El Kebir D, Damlaj A, Filep J. Toll-like receptor 9 signaling delays neutrophil apoptosis by increasing transcription of Mcl-1. PLoS ONE. 2014;9:e87006 pubmed publisher
Bratke K, Prieschenk C, Garbe K, Kuepper M, Lommatzsch M, Virchow J. Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment. Clin Exp Allergy. 2013;43:312-21 pubmed publisher
Freeman C, Martinez F, Han M, Washko G, McCubbrey A, Chensue S, et al. Lung CD8+ T cells in COPD have increased expression of bacterial TLRs. Respir Res. 2013;14:13 pubmed publisher
Fierro M, Banche G, Marenco F, Novelli M, Allizond V, Mandras N, et al. Functional and phenotypical impairment of polymorphonuclear cells in atopic dermatitis: an additional cause for the known susceptibility to infections?. Dermatology. 2012;224:323-30 pubmed publisher
Garbe K, Bratke K, Wagner S, Virchow J, Lommatzsch M. Plasmacytoid dendritic cells and their Toll-like receptor 9 expression selectively decrease with age. Hum Immunol. 2012;73:493-7 pubmed publisher
Fierro M, Cuffini A, Novelli M, Banche G, Allizond V, Comessatti A, et al. Functional and phenotypical alterations of polymorphonuclear cells in Sézary syndrome patients. Eur J Dermatol. 2011;21:921-9 pubmed publisher
Dasari P, Zola H, Nicholson I. Expression of Toll-like receptors by neonatal leukocytes. Pediatr Allergy Immunol. 2011;22:221-8 pubmed publisher
Bratke K, Klein C, Kuepper M, Lommatzsch M, Virchow J. Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus. Allergy. 2011;66:386-95 pubmed publisher
Llinàs L, Lázaro A, de Salort J, Matesanz Isabel J, Sintes J, Engel P. Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry. Immunol Lett. 2011;134:113-21 pubmed publisher
Cabezón R, Sintes J, Llinàs L, Benitez Ribas D. Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. Immunol Lett. 2011;134:167-73 pubmed publisher
Kiemer A, Senaratne R, Hoppstädter J, Diesel B, Riley L, Tabeta K, et al. Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria. J Innate Immun. 2009;1:29-45 pubmed publisher
Liu F, Li G, Wen K, Bui T, Cao D, Zhang Y, et al. Porcine small intestinal epithelial cell line (IPEC-J2) of rotavirus infection as a new model for the study of innate immune responses to rotaviruses and probiotics. Viral Immunol. 2010;23:135-49 pubmed publisher
Neves P, Matos D, Marcovistz R, Galler R. TLR expression and NK cell activation after human yellow fever vaccination. Vaccine. 2009;27:5543-9 pubmed publisher
Zorro S, Arias M, Riano F, Paris S, Ramirez L, Uribe O, et al. Response to ODN-CpG by B Cells from patients with systemic lupus erythematosus correlates with disease activity. Lupus. 2009;18:718-26 pubmed publisher
Martín Martín L, Almeida J, Hernández Campo P, Sanchez M, Lecrevisse Q, Orfao A. Immunophenotypical, morphologic, and functional characterization of maturation-associated plasmacytoid dendritic cell subsets in normal adult human bone marrow. Transfusion. 2009;49:1692-1708 pubmed publisher
El Kebir D, Jozsef L, Pan W, Wang L, Filep J. Bacterial DNA activates endothelial cells and promotes neutrophil adherence through TLR9 signaling. J Immunol. 2009;182:4386-94 pubmed publisher
Wen K, Azevedo M, Gonzalez A, Zhang W, Saif L, Li G, et al. Toll-like receptor and innate cytokine responses induced by lactobacilli colonization and human rotavirus infection in gnotobiotic pigs. Vet Immunol Immunopathol. 2009;127:304-15 pubmed publisher
Peiser M, Koeck J, Kirschning C, Wittig B, Wanner R. Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity. J Leukoc Biol. 2008;83:1118-27 pubmed publisher
Loharungsikul S, Troye Blomberg M, Amoudruz P, Pichyangkul S, Yongvanitchit K, Looareesuwan S, et al. Expression of toll-like receptors on antigen-presenting cells in patients with falciparum malaria. Acta Trop. 2008;105:10-5 pubmed
Hoene V, Peiser M, Wanner R. Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19. J Leukoc Biol. 2006;80:1328-36 pubmed
Leifer C, Brooks J, Hoelzer K, Lopez J, Kennedy M, Mazzoni A, et al. Cytoplasmic targeting motifs control localization of toll-like receptor 9. J Biol Chem. 2006;281:35585-92 pubmed
Lee H, Dunzendorfer S, Soldau K, Tobias P. Double-stranded RNA-mediated TLR3 activation is enhanced by CD14. Immunity. 2006;24:153-63 pubmed
Jozsef L, Khreiss T, El Kebir D, Filep J. Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils. J Immunol. 2006;176:1195-202 pubmed
Droemann D, Albrecht D, Gerdes J, Ulmer A, Branscheid D, Vollmer E, et al. Human lung cancer cells express functionally active Toll-like receptor 9. Respir Res. 2005;6:1 pubmed
Eaton Bassiri A, Dillon S, Cunningham M, Rycyzyn M, Mills J, Sarisky R, et al. Toll-like receptor 9 can be expressed at the cell surface of distinct populations of tonsils and human peripheral blood mononuclear cells. Infect Immun. 2004;72:7202-11 pubmed
Platz J, Beisswenger C, Dalpke A, Koczulla R, Pinkenburg O, Vogelmeier C, et al. Microbial DNA induces a host defense reaction of human respiratory epithelial cells. J Immunol. 2004;173:1219-23 pubmed
product information
Product Type :
Antibody
Product Name :
CD289 (TLR9) Monoclonal Antibody (eB72-1665), eBioscience™
Catalog # :
14-9099-82
Quantity :
100 µg
Price :
279 USD
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Human
Applications :
Flow Cytometry: 1 µg/test, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent
Species :
Human
Clone :
eB72-1665
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
CD289; Tlr9; toll like receptor 9; toll-like receptor 9; UNQ5798/PRO19605
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA