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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD284 (TLR4) Monoclonal Antibody (UT41), eBioscience™
catalog :
14-9041-80
quantity :
25 µg
price :
98.25 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
UT41
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 31
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; fig 2
Yang L, Carrillo M, Wu Y, DiAngelo S, Silveyra P, Umstead T, et al. SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation. PLoS ONE. 2015;10:e0126576 pubmed publisher
Petrovic I, Pejnovic N, Ljujic B, Pavlovic S, Miletic Kovacevic M, Jeftic I, et al. Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice. Front Endocrinol (Lausanne). 2020;11:30 pubmed publisher
Li Z, Scott M, Fan E, Li Y, Liu J, Xiao G, et al. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ. 2016;23:1428-47 pubmed publisher
Ninkovic J, Jana N, Anand V, Vidhu A, Dutta R, Raini D, et al. Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis. Sci Rep. 2016;6:21094 pubmed publisher
Li X, Wang J, Wang W, Liu C, Sun S, Gu J, et al. Immunomodulatory activity of a novel, synthetic beta-glucan (?-glu6) in murine macrophages and human peripheral blood mononuclear cells. PLoS ONE. 2013;8:e80399 pubmed publisher
Thirunavukkarasu S, de Silva K, Whittington R, Plain K. In vivo and in vitro expression pattern of Toll-like receptors in Mycobacterium avium subspecies paratuberculosis infection. Vet Immunol Immunopathol. 2013;156:20-31 pubmed publisher
Liu C, Zhang C, Mitchel R, Cui J, Lin J, Yang Y, et al. A critical role of toll-like receptor 4 (TLR4) and its' in vivo ligands in basal radio-resistance. Cell Death Dis. 2013;4:e649 pubmed publisher
Casella C, Mitchell T. Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A. PLoS ONE. 2013;8:e62622 pubmed publisher
Liu B, Fu Y, Feng S, Zhang X, Liu Z, Cao Y, et al. Involvement of RP105 and toll-like receptors in the activation of mouse peritoneal macrophages by Staphylococcus aureus. Scand J Immunol. 2013;78:8-16 pubmed publisher
Roberts B, Dragon J, Moussawi M, Huber S. Sex-specific signaling through Toll-Like Receptors 2 and 4 contributes to survival outcome of Coxsackievirus B3 infection in C57Bl/6 mice. Biol Sex Differ. 2012;3:25 pubmed publisher
Zhang W, Wang X, Xia X, Liu X, Suo S, Guo J, et al. Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages. Eur J Immunol. 2013;43:258-69 pubmed publisher
Aaron J, Carson B, Timlin J. Characterization of differential Toll-like receptor responses below the optical diffraction limit. Small. 2012;8:3041-9 pubmed publisher
Lee H, Hattori T, Park E, Stevenson W, Chauhan S, Dana R. Expression of toll-like receptor 4 contributes to corneal inflammation in experimental dry eye disease. Invest Ophthalmol Vis Sci. 2012;53:5632-40 pubmed publisher
Yang D, Liu Y, Chen Y, Jiao D, Hou X, Wang L, et al. Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis. Int J Mol Med. 2012;29:1072-82 pubmed publisher
Traves P, López Fontal R, Luque A, Hortelano S. The tumor suppressor ARF regulates innate immune responses in mice. J Immunol. 2011;187:6527-38 pubmed publisher
Yang H, Wang J, Mi S, Liu H, Cui B, Yan H, et al. TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol. 2012;180:275-92 pubmed publisher
Scotland R, Stables M, Madalli S, Watson P, Gilroy D. Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice. Blood. 2011;118:5918-27 pubmed publisher
Miranda Hernandez S, Gerlach N, Fletcher J, Biros E, Mack M, Korner H, et al. Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in experimental autoimmune encephalomyelitis. J Immunol. 2011;187:791-804 pubmed publisher
Fernandez S, Cisney E, Hall S, Ulrich R. Nasal immunity to staphylococcal toxic shock is controlled by the nasopharynx-associated lymphoid tissue. Clin Vaccine Immunol. 2011;18:667-75 pubmed publisher
Li Z, Potts E, Piantadosi C, Foster W, Hollingsworth J. Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide. J Immunol. 2010;185:6891-8 pubmed publisher
Niess J, Adler G. Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J Immunol. 2010;184:2026-37 pubmed publisher
Oliveira C, Carvalho W, Garcia G, Gutierrez F, De Miranda Santos I, Silva J, et al. Tick saliva induces regulatory dendritic cells: MAP-kinases and Toll-like receptor-2 expression as potential targets. Vet Parasitol. 2010;167:288-97 pubmed publisher
Wang L, Harrington L, Trebicka E, Shi H, Kagan J, Hong C, et al. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest. 2009;119:3322-8 pubmed publisher
Segura E, Wong J, Villadangos J. Cutting edge: B220+CCR9- dendritic cells are not plasmacytoid dendritic cells but are precursors of conventional dendritic cells. J Immunol. 2009;183:1514-7 pubmed publisher
Dasu M, Park S, Devaraj S, Jialal I. Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice. Endocrinology. 2009;150:3457-64 pubmed publisher
Meyer M, Huaux F, Gavilanes X, van den Brule S, Lebecque P, Lo Re S, et al. Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis. Am J Respir Cell Mol Biol. 2009;41:590-602 pubmed publisher
Bi Y, Du Z, Han Y, Guo Z, Tan Y, Zhu Z, et al. Yersinia pestis and host macrophages: immunodeficiency of mouse macrophages induced by YscW. Immunology. 2009;128:e406-17 pubmed publisher
Tokita D, Sumpter T, Raimondi G, Zahorchak A, Wang Z, Nakao A, et al. Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells. J Hepatol. 2008;49:1008-18 pubmed publisher
Dasu M, Riosvelasco A, Jialal I. Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo. Atherosclerosis. 2009;202:76-83 pubmed publisher
Hollingsworth J, Maruoka S, Li Z, Potts E, Brass D, Garantziotis S, et al. Ambient ozone primes pulmonary innate immunity in mice. J Immunol. 2007;179:4367-75 pubmed
Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M, et al. Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol. 2000;164:3476-9 pubmed
product information
Product Type :
Antibody
Product Name :
CD284 (TLR4) Monoclonal Antibody (UT41), eBioscience™
Catalog # :
14-9041-80
Quantity :
25 µg
Price :
98.25 USD
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Mouse
Clone :
UT41
Isotype :
IgG1, kappa
Storage :
4° C
Description :
TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA