CD283 (TLR3) Monoclonal Antibody (TLR3.7), eBioscience™ | Invitrogen 14-9039-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD283 (TLR3) Monoclonal Antibody (TLR3.7), eBioscience™

catalog :

14-9039-82

quantity :

100 µg

price :

307 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TLR3.7

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 21

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse; fig 2	Wang J, Yin T, Wen Y, Tian F, He X, Zhou D, et al. Potential effects of interferon regulatory factor 4 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption. Reprod Fertil Dev. 2015;: pubmed publisher
flow cytometry; human; fig 8	Babu R, Brown A. A consensus surface activation marker signature is partially dependent on human immunodeficiency virus type 1 Nef expression within productively infected macrophages. Retrovirology. 2013;10:155 pubmed publisher
	Zayed R, Omran D, Mokhtar D, Zakaria Z, Ezzat S, Soliman M, et al. Association of Toll-Like Receptor 3 and Toll-Like Receptor 9 Single Nucleotide Polymorphisms with Hepatitis C Virus Infection and Hepatic Fibrosis in Egyptian Patients. Am J Trop Med Hyg. 2017;96:720-726 pubmed publisher
	Dixon D, Coates J, Del Carpio Pons A, Horabin J, Walker A, Abdul N, et al. A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty. Sci Rep. 2015;5:16466 pubmed publisher
	Weiss R, Laengle J, Sachet M, Shurygina A, Kiselev O, Egorov A, et al. Interleukin-24 inhibits influenza A virus replication in vitro through induction of toll-like receptor 3 dependent apoptosis. Antiviral Res. 2015;123:93-104 pubmed publisher
	Wei Y, Xia W, Ye X, Fan Y, Shi J, Wen W, et al. The antimicrobial protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is differentially modulated in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2014;133:420-8 pubmed publisher
	Mayumi N, Watanabe E, Norose Y, Watari E, Kawana S, Geijtenbeek T, et al. E-cadherin interactions are required for Langerhans cell differentiation. Eur J Immunol. 2013;43:270-80 pubmed publisher
	Tao S, Zhu L, Lee P, Lee W, Knox K, Chen J, et al. Negative control of TLR3 signaling by TICAM1 down-regulation. Am J Respir Cell Mol Biol. 2012;46:660-7 pubmed publisher
	Romieu Mourez R, Francois M, Boivin M, Bouchentouf M, Spaner D, Galipeau J. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol. 2009;182:7963-73 pubmed publisher
	Ranjith Kumar C, Duffy K, Jordan J, Eaton Bassiri A, Vaughan R, Hoose S, et al. Single-stranded oligonucleotides can inhibit cytokine production induced by human toll-like receptor 3. Mol Cell Biol. 2008;28:4507-19 pubmed publisher
	Wong C, Cheung P, Ip W, Lam C. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007;37:85-96 pubmed
	Wornle M, Schmid H, Banas B, Merkle M, Henger A, Roeder M, et al. Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis. Am J Pathol. 2006;168:370-85 pubmed
	Ciencewicki J, Brighton L, Wu W, Madden M, Jaspers I. Diesel exhaust enhances virus- and poly(I:C)-induced Toll-like receptor 3 expression and signaling in respiratory epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006;290:L1154-63 pubmed
	Schreiner B, Voss J, Wischhusen J, Dombrowski Y, Steinle A, Lochmuller H, et al. Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands. FASEB J. 2006;20:118-20 pubmed
	Sanghavi S, Reinhart T. Increased expression of TLR3 in lymph nodes during simian immunodeficiency virus infection: implications for inflammation and immunodeficiency. J Immunol. 2005;175:5314-23 pubmed
	Hewson C, Jardine A, Edwards M, Laza Stanca V, Johnston S. Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cells. J Virol. 2005;79:12273-9 pubmed
	Jorgenson R, Young S, Lesmeister M, Lyddon T, Misfeldt M. Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA. Hum Immunol. 2005;66:469-82 pubmed
	Kariko K, Ni H, Capodici J, Lamphier M, Weissman D. mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem. 2004;279:12542-50 pubmed
	Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol. 2003;4:161-7 pubmed
	Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun. 2002;293:1364-9 pubmed
	Alexopoulou L, Holt A, Medzhitov R, Flavell R. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413:732-8 pubmed

product information

Product Type :

Antibody

Product Name :

CD283 (TLR3) Monoclonal Antibody (TLR3.7), eBioscience™

Catalog # :

14-9039-82

Quantity :

100 µg

Price :

307 USD

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 2 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent

Species :

Human

Clone :

TLR3.7

Isotype :

IgG1, kappa

Storage :

4° C

Description :

TLR3 (Toll-like receptor 3, CD283) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. TLR3 recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. Further, TLR3 may play a role in host defense against viruses, and the use of alternative polyadenylation sites to generate different length transcripts has been noted for the TLR3 gene. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kB. TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 2 µg/test, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent

Aliases :

AI957183; CD283; IIAE2; TLR 3; TLR3; TLR-3; toll like receptor 3; toll-like receptor 3; toll-like receptor 3 variant 1

more info or order :

Invitrogen product webpage