This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-4), eBioscience
catalog :
14-9018-80
quantity :
25 ug
price :
US 149.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
ITEM-4

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section
citations: 28
Reference
G xfc ner G, A xdf falg M, Zhao K, Dreyer T, Lahiri S, Lo Y, et al. Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity. EMBO Mol Med. 2022;14:e16084 pubmed publisher
Slavin V, Gamble J, Creedy D, Fenwick J, Pallant J. Measuring physical and mental health during pregnancy and postpartum in an Australian childbearing population - validation of the PROMIS Global Short Form. BMC Pregnancy Childbirth. 2019;19:370 pubmed publisher
Choe Y, Byun M, Yi D, Lee J, Jeon S, Sohn B, et al. Sleep experiences during different lifetime periods and in vivo Alzheimer pathologies. Alzheimers Res Ther. 2019;11:79 pubmed publisher
Lee S, Kim J, Ko J, Lee E, Koh H, Yoon J. Tumor necrosis factor-like weak inducer of apoptosis induces inflammation in Graves' orbital fibroblasts. PLoS ONE. 2018;13:e0209583 pubmed publisher
Potter C, Batchelder L, A Court C, Geneen L, Kelly L, Fox D, et al. Long-Term Conditions Questionnaire (LTCQ): initial validation survey among primary care patients and social care recipients in England. BMJ Open. 2017;7:e019235 pubmed publisher
Farooq M, Mohseni Bandpei M, Gilani S, Hafeez A. Urdu version of the neck disability index: a reliability and validity study. BMC Musculoskelet Disord. 2017;18:149 pubmed publisher
Cheng Q, Inaba Y, Lu P, Xu M, He J, Zhao Y, et al. Chronic activation of FXR in transgenic mice caused perinatal toxicity and sensitized mice to cholesterol toxicity. Mol Endocrinol. 2015;29:571-82 pubmed publisher
Schneider C, Perez J, CHENG E, Zhang C, Mastorakos P, Hanes J, et al. Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells. Biomaterials. 2015;42:42-51 pubmed publisher
Gurunathan S, Winkles J, Ghosh S, Hayden M. Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. J Biol Chem. 2014;289:12976-88 pubmed publisher
Pachel C, Mathes D, Bayer B, Dienesch C, Wangorsch G, Heitzmann W, et al. Exogenous administration of a recombinant variant of TWEAK impairs healing after myocardial infarction by aggravation of inflammation. PLoS ONE. 2013;8:e78938 pubmed publisher
Moreno J, Sastre C, Madrigal Matute J, Munoz Garcia B, Ortega L, Burkly L, et al. HMGB1 expression and secretion are increased via TWEAK-Fn14 interaction in atherosclerotic plaques and cultured monocytes. Arterioscler Thromb Vasc Biol. 2013;33:612-20 pubmed publisher
Yoriki R, Akashi S, Sho M, Nomi T, Yamato I, Hotta K, et al. Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer. Exp Ther Med. 2011;2:103-108 pubmed
Roos C, Wicovsky A, Muller N, Salzmann S, Rosenthal T, Kalthoff H, et al. Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. J Immunol. 2010;185:1593-605 pubmed publisher
Muller N, Schneider B, Pfizenmaier K, Wajant H. Superior serum half life of albumin tagged TNF ligands. Biochem Biophys Res Commun. 2010;396:793-9 pubmed publisher
Tiller G, Fischer Posovszky P, Laumen H, Finck A, Skurk T, Keuper M, et al. Effects of TWEAK (TNF superfamily member 12) on differentiation, metabolism, and secretory function of human primary preadipocytes and adipocytes. Endocrinology. 2009;150:5373-83 pubmed publisher
Chorianopoulos E, Heger T, Lutz M, Frank D, Bea F, Katus H, et al. FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK. Basic Res Cardiol. 2010;105:301-13 pubmed publisher
Moreno J, Munoz Garcia B, Martin Ventura J, Madrigal Matute J, Orbe J, Paramo J, et al. The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis. Atherosclerosis. 2009;207:103-10 pubmed publisher
Sanz A, Sanchez Nino M, Izquierdo M, Jakubowski A, Justo P, Blanco Colio L, et al. Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia. J Cell Mol Med. 2009;13:3329-42 pubmed publisher
Vincent C, Findlay D, Welldon K, Wijenayaka A, Zheng T, Haynes D, et al. Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. J Bone Miner Res. 2009;24:1434-49 pubmed publisher
Desplat Jego S, Feuillet L, Creidy R, Malikova I, Rance R, Khrestchatisky M, et al. TWEAK is expressed at the cell surface of monocytes during multiple sclerosis. J Leukoc Biol. 2009;85:132-5 pubmed publisher
Sanz A, Justo P, Sanchez Nino M, Blanco Colio L, Winkles J, Kreztler M, et al. The cytokine TWEAK modulates renal tubulointerstitial inflammation. J Am Soc Nephrol. 2008;19:695-703 pubmed publisher
Wako M, Haro H, Ando T, Hatsushika K, Ohba T, Iwabuchi S, et al. Novel function of TWEAK in inducing intervertebral disc degeneration. J Orthop Res. 2007;25:1438-46 pubmed
Perper S, Browning B, Burkly L, Weng S, Gao C, Giza K, et al. TWEAK is a novel arthritogenic mediator. J Immunol. 2006;177:2610-20 pubmed
Jakubowski A, Ambrose C, Parr M, Lincecum J, Wang M, Zheng T, et al. TWEAK induces liver progenitor cell proliferation. J Clin Invest. 2005;115:2330-40 pubmed
Potrovita I, Zhang W, Burkly L, Hahm K, Lincecum J, Wang M, et al. Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration. J Neurosci. 2004;24:8237-44 pubmed
Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, et al. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol. 2003;170:341-8 pubmed
Harada N, Nakayama M, Nakano H, Fukuchi Y, Yagita H, Okumura K. Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2002;299:488-93 pubmed
Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, et al. Multiple pathways of TWEAK-induced cell death. J Immunol. 2002;168:734-43 pubmed
product information
Product Type :
Antibody
Product Name :
CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-4), eBioscience
Catalog # :
14-9018-80
Quantity :
25 ug
Price :
US 149.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 1 ug/test, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent
Species :
Human, Mouse
Clone :
ITEM-4
Isotype :
IgG2b, kappa
Storage :
4 C
Description :
TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA