Phospho-S6 (Ser235, Ser236) Monoclonal Antibody (cupk43k), eBioscience | Invitrogen 14-9007-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-S6 (Ser235, Ser236) Monoclonal Antibody (cupk43k), eBioscience

catalog :

14-9007-82

quantity :

100 ug

price :

US 396.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

cupk43k

reactivity :

human, mouse

application :

western blot, flow cytometry

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 2	Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, et al. Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. J Clin Invest. 2017;127:2789-2804 pubmed publisher
	Borsa M, Obba S, Richter F, Zhang H, Riffelmacher T, Carrelha J, et al. Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism. Autophagy. 2024;20:45-57 pubmed publisher
	Seipel K, Schmitter K, Bacher U, Pabst T. Rationale for a Combination Therapy Consisting of MCL1- and MEK-Inhibitors in Acute Myeloid Leukemia. Cancers (Basel). 2019;11: pubmed publisher
	Farmer J, Allard Chamard H, Sun N, Ahmad M, Bertocchi A, Mahajan V, et al. Induction of metabolic quiescence defines the transitional to follicular B cell switch. Sci Signal. 2019;12: pubmed publisher
	Wilski N, Del Casale C, Purwin T, Aplin A, Snyder C. Murine Cytomegalovirus Infection of Melanoma Lesions Delays Tumor Growth by Recruiting and Repolarizing Monocytic Phagocytes in the Tumor. J Virol. 2019;93: pubmed publisher
	Tanaka S, Pfleger C, Lai J, Roan F, Sun S, Ziegler S. KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners. Cell Rep. 2018;23:796-807 pubmed publisher
	Mittal P, Abblett R, Ryan J, Hagymasi A, Agyekum Yamoah A, Svedova J, et al. An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells. J Immunol. 2018;200:1513-1526 pubmed publisher
	Yuan X, Yang B, Dong Y, Yamamura A, Fu W. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells. elife. 2017;6: pubmed publisher
	Jastrzebski K, Hannan K, Tchoubrieva E, Hannan R, Pearson R. Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function. Growth Factors. 2007;25:209-26 pubmed
	Shah O, Hunter T. Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex. J Biol Chem. 2004;279:20816-23 pubmed
	Peterson R, Schreiber S. Translation control: connecting mitogens and the ribosome. Curr Biol. 1998;8:R248-50 pubmed
	Flotow H, Thomas G. Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver. J Biol Chem. 1992;267:3074-8 pubmed

product information

Product Type :

Antibody

Product Name :

Phospho-S6 (Ser235, Ser236) Monoclonal Antibody (cupk43k), eBioscience

Catalog # :

14-9007-82

Quantity :

100 ug

Price :

US 396.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: Assay-Dependent, Western Blot: 1:1,000

Species :

Human, Mouse

Clone :

cupk43k

Isotype :

IgG1, kappa

Storage :

4 C

Description :

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent, Western Blot: 1:1,000

Aliases :

(Rp)S6; 40S ribosomal protein S6; air[8]; air8; anon-WO02059370.61; CG10944; CG10944-PA; CG10944-PB; Dmel CG10944; Dmel_CG10944; DS6; hemocytes enlarged; hen; l(1)air[8]; l(1)air8; l(1)hen; LD31286p; lethal(1)aberrant immune response[8]; lethal-(1)-haemocytes enlarged; lethal-aberrant-immune-response-8; M(1)7BC; M(1)7C; minute; minute (1) 7BC; OK/SW-cl.2; OTTHUMP00000021121; OTTHUMP00000021122; Phosphoprotein NP33; pp30; ribosomal protein S6; Rp S6; RP11-513M16.6; RPS6; RpS6-PA; RpS6-PB; RS6; S6; S6 ribosomal protein; S6R; Small ribosomal subunit protein eS6; wu:fa92e06; wu:fb64g06; zgc:92237

more info or order :

Invitrogen product webpage