Granzyme B Monoclonal Antibody (16G6), eBioscience | Invitrogen 14-8822-37 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Granzyme B Monoclonal Antibody (16G6), eBioscience

catalog :

14-8822-37

quantity :

2 mg

price :

US 1482.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

16G6

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 22

Reference
Chun J, Park S, Lee M, Ha I, Jeong M. The Sesquiterpene Lactone-Rich Fraction of Inula helenium L. Enhances the Antitumor Effect of Anti-PD-1 Antibody in Colorectal Cancer: Integrative Phytochemical, Transcriptomic, and Experimental Analyses. Cancers (Basel). 2023;15: pubmed publisher
Faraoni E, Strickland L, O Brien B, Barraza J, Thosani N, Wray C, et al. Radiofrequency ablation in combination with CD73 inhibitor AB680 reduces tumor growth and enhances anti-tumor immunity in a syngeneic model of pancreatic ductal adenocarcinoma. Front Oncol. 2022;12:995027 pubmed publisher
Jiang L, Wang Y, Zhao J, Uehara M, Hou Q, Kasinath V, et al. Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy. Cell. 2020;183:1219-1233.e18 pubmed publisher
Luu M, Weigand K, Wedi F, Breidenbend C, Leister H, Pautz S, et al. Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate. Sci Rep. 2018;8:14430 pubmed publisher
Wang J, Xie T, Wang B, William W, Heymach J, El Naggar A, et al. PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions. Cancer Prev Res (Phila). 2017;10:684-693 pubmed publisher
Konishi M, Erdem S, Weissleder R, Lichtman A, McCarthy J, Libby P. Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis. Circ Res. 2015;117:502-512 pubmed publisher
Andoniou C, Sutton V, Wikstrom M, Fleming P, Thia K, Matthews A, et al. A natural genetic variant of granzyme B confers lethality to a common viral infection. PLoS Pathog. 2014;10:e1004526 pubmed publisher
Boulet S, Daudelin J, Labrecque N. IL-2 induction of Blimp-1 is a key in vivo signal for CD8+ short-lived effector T cell differentiation. J Immunol. 2014;193:1847-54 pubmed publisher
Bird C, Christensen M, Mangan M, Prakash M, Sedelies K, Smyth M, et al. The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress. Cell Death Differ. 2014;21:876-87 pubmed publisher
Drobits B, Holcmann M, Amberg N, Swiecki M, Grundtner R, Hammer M, et al. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J Clin Invest. 2012;122:575-85 pubmed publisher
Wiesel M, Crouse J, Bedenikovic G, Sutherland A, Joller N, Oxenius A. Type-I IFN drives the differentiation of short-lived effector CD8+ T cells in vivo. Eur J Immunol. 2012;42:320-9 pubmed publisher
Schmidt R, Filak H, Lemon J, Potter T, Lenz L. A LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein stimulates accessory cells to promote activation of host NK cells. PLoS Pathog. 2011;7:e1002368 pubmed publisher
Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park J, et al. Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J. 2012;31:366-77 pubmed publisher
Zappasodi R, Bongarzone I, Ghedini G, Castagnoli L, Cabras A, Messina A, et al. Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target. Blood. 2011;118:4421-30 pubmed publisher
Tabbekh M, Franciszkiewicz K, Haouas H, Lecluse Y, Benihoud K, Raman C, et al. Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice. J Immunol. 2011;187:102-9 pubmed publisher
McCarl C, Khalil S, Ma J, Oh Hora M, Yamashita M, Roether J, et al. Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection. J Immunol. 2010;185:5845-58 pubmed publisher
Haeberlein S, Sebald H, Bogdan C, Schleicher U. IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo. Eur J Immunol. 2010;40:1708-17 pubmed publisher
Xie Y, Akpinarli A, Maris C, Hipkiss E, Lane M, Kwon E, et al. Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma. J Exp Med. 2010;207:651-67 pubmed publisher
Zhao J, Zhao J, Perlman S. De novo recruitment of antigen-experienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system. J Immunol. 2009;183:5163-70 pubmed publisher
Itsumi M, Yoshikai Y, Yamada H. IL-15 is critical for the maintenance and innate functions of self-specific CD8(+) T cells. Eur J Immunol. 2009;39:1784-93 pubmed publisher
Ahonen C, Wasiuk A, Fuse S, Turk M, Ernstoff M, Suriawinata A, et al. Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines. Blood. 2008;111:3116-25 pubmed publisher
Sadighi Akha A, Berger S, Miller R. Enhancement of CD8 T-cell function through modifying surface glycoproteins in young and old mice. Immunology. 2006;119:187-94 pubmed

product information

Product Type :

Antibody

Product Name :

Granzyme B Monoclonal Antibody (16G6), eBioscience

Catalog # :

14-8822-37

Quantity :

2 mg

Price :

US 1482.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

ELISA: 1-4 ug/mL, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1 ug/mL

Species :

Human, Mouse

Clone :

16G6

Isotype :

IgG2b, kappa

Storage :

4 C

Description :

Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1-4 ug/mL, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1 ug/mL

Aliases :

AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E