Mouse IL-23 Recombinant Protein, eBioscience | Invitrogen 14-8231-63 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Mouse IL-23 Recombinant Protein, eBioscience

catalog :

14-8231-63

quantity :

10 ug

price :

US 453.00

citations: 10

Reference
Kiyohara H, Sujino T, Teratani T, Miyamoto K, Arai M, Nomura E, et al. Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells. Cell Mol Gastroenterol Hepatol. 2019;7:135-156 pubmed publisher
Glal D, Sudhakar J, Lu H, Liu M, Chiang H, Liu Y, et al. ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases. Front Immunol. 2018;9:2522 pubmed publisher
Moore M, Blachere N, Fak J, Park C, Sawicka K, Parveen S, et al. ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity. elife. 2018;7: pubmed publisher
Emgård J, Kammoun H, García Cassani B, Chesne J, Parigi S, Jacob J, et al. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation. Immunity. 2018;48:120-132.e8 pubmed publisher
Keller C, Sina C, Kotur M, Ramelli G, Mundt S, Quast I, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114:E11228-E11237 pubmed publisher
Mowel W, McCright S, Kotzin J, Collet M, Uyar A, Chen X, et al. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity. 2017;47:435-449.e8 pubmed publisher
Chen J, Martindale J, Cramer C, Gorospe M, Atasoy U, Drew P, et al. The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells. J Biol Chem. 2017;292:14532-14543 pubmed publisher
Tosiek M, Fiette L, El Daker S, Eberl G, Freitas A. IL-15-dependent balance between Foxp3 and RORÎ³t expression impacts inflammatory bowel disease. Nat Commun. 2016;7:10888 pubmed publisher
Withers D, Hepworth M, Wang X, Mackley E, Halford E, Dutton E, et al. Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells. Nat Med. 2016;22:319-23 pubmed publisher
Stromnes I, GOVERMAN J. Passive induction of experimental allergic encephalomyelitis. Nat Protoc. 2006;1:1952-60 pubmed

product information

Product Type :

Protein

Product Name :

Mouse IL-23 Recombinant Protein, eBioscience

Catalog # :

14-8231-63

Quantity :

10 ug

Price :

US 453.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Mouse

Applications :

Control: Assay-Dependent, ELISA: Assay-Dependent, Functional Assay: Assay-Dependent, Western Blot: Assay-dependent

Species :

Mouse

Storage :

-80 C

Description :

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN- . Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN- production by naive and memory T cells, as compared to IL-12.

Format :

Liquid

Applications w/Dilutions :

Control: Assay-Dependent, ELISA: Assay-Dependent, Functional Assay: Assay-Dependent, Western Blot: Assay-dependent

Aliases :

il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798