IL-21 Monoclonal Antibody (eBio3A3-N2 (3A3-N2)), eBioscience™ | Invitrogen 14-7219-95 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-21 Monoclonal Antibody (eBio3A3-N2 (3A3-N2)), eBioscience™

catalog :

14-7219-95

quantity :

10 mg

price :

3000.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

eBio3A3-N2 (3A3-N2)

reactivity :

human

application :

ELISA

more info or order :

Invitrogen product webpage

citations: 6

Reference
Verghese D, Chun N, Paz K, Fribourg M, Woodruff T, Flynn R, et al. C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans. JCI Insight. 2018;3: pubmed publisher
Dige A, Magnusson M, Uhrenholt C, Rasmussen T, Kragstrup T, Ohman L, et al. Effects of Anti-TNFα Treatment on Mucosal Expression of IL-17A, IL-21, and IL-22 and Cytokine-Producing T Cell Subsets in Crohn's Disease. Mediators Inflamm. 2018;2018:3279607 pubmed publisher
Rasmussen T, Andersen T, Bak R, Yiu G, SÃ¸rensen C, Stengaard Pedersen K, et al. Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. Arthritis Res Ther. 2015;17:154 pubmed publisher
Herati R, Reuter M, Dolfi D, Mansfield K, Aung H, Badwan O, et al. Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults. J Immunol. 2014;193:3528-37 pubmed publisher
Singh H, Figliola M, Dawson M, Huls H, Olivares S, Switzer K, et al. Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies. Cancer Res. 2011;71:3516-27 pubmed publisher
Hovhannisyan Z, Treatman J, Littman D, Mayer L. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011;140:957-65 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IL-21 Monoclonal Antibody (eBio3A3-N2 (3A3-N2)), eBioscience™

Catalog # :

14-7219-95

Quantity :

10 mg

Price (USD) :

3000.00 USD

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 1-4 µg/mL

Species :

Human

Clone :

eBio3A3-N2 (3A3-N2)

Isotype :

IgG1, kappa

Storage :

4° C

Description :

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1-4 µg/mL

Aliases :

CVID11; CX2; il 21; Il21; IL-21; ILN; Interleukin; interleukin 21; interleukin 21-like; Interleukin21; interleukin-21; interleukin-21 isoform; LOC100344172; porcine interleukin-21; Za11

more info or order :

Invitrogen product webpage