IL-17A Monoclonal Antibody (eBio64DEC17), eBioscience™ | Invitrogen 14-7179-95 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-17A Monoclonal Antibody (eBio64DEC17), eBioscience™

catalog :

14-7179-95

quantity :

10 mg

price :

3000.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

eBio64DEC17

reactivity :

human

application :

ELISA, immunohistochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 45

Reference
Doh K, Kim B, Kim K, Chung B, Yang C. Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression. BMC Complement Altern Med. 2019;19:54 pubmed publisher
Chen X, Wang Y, Wang J, Wen J, Jia X, Wang X, et al. Accumulation of T-helper 22 cells, interleukin-22 and myeloid-derived suppressor cells promotes gastric cancer progression in elderly patients. Oncol Lett. 2018;16:253-261 pubmed publisher
Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang T, et al. Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis. Nat Commun. 2017;8:1600 pubmed publisher
Tischner D, Grimm M, Kaur H, Staudenraus D, Carvalho J, Looso M, et al. Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation. JCI Insight. 2017;2: pubmed publisher
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Wattegedera S, Corripio Miyar Y, Pang Y, Frew D, McNeilly T, Palarea Albaladejo J, et al. Enhancing the toolbox to study IL-17A in cattle and sheep. Vet Res. 2017;48:20 pubmed publisher
Yang Y, Wang Q, Xie M, Liu P, Qi X, Liu X, et al. Berberine exerts an anti-inflammatory role in ocular Behcet's disease. Mol Med Rep. 2017;15:97-102 pubmed publisher
Zhu H, Hu F, Sun X, Zhang X, Zhu L, Liu X, et al. CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus. Front Immunol. 2016;7:512 pubmed
Prodger J, Gray R, Shannon B, Shahabi K, Kong X, Grabowski K, et al. Chemokine Levels in the Penile Coronal Sulcus Correlate with HIV-1 Acquisition and Are Reduced by Male Circumcision in Rakai, Uganda. PLoS Pathog. 2016;12:e1006025 pubmed publisher
Pachnio A, Ciáurriz M, Begum J, Lal N, Zuo J, Beggs A, et al. Cytomegalovirus Infection Leads to Development of High Frequencies of Cytotoxic Virus-Specific CD4+ T Cells Targeted to Vascular Endothelium. PLoS Pathog. 2016;12:e1005832 pubmed publisher
Noack M, Ndongo Thiam N, Miossec P. Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion. Arthritis Res Ther. 2016;18:148 pubmed publisher
CalderÃ³n GÃ³mez E, Bassolas Molina H, Mora Buch R, Dotti I, Planell N, Esteller M, et al. Commensal-Specific CD4(+) Cells From Patients With Crohn's Disease Have a T-Helper 17 Inflammatory Profile. Gastroenterology. 2016;151:489-500.e3 pubmed publisher
Liang D, Hou Y, Luo L, Ao L. Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis. Int J Mol Med. 2016;38:131-8 pubmed publisher
Moreira M, Costa Pereira C, Alves M, Marteleto B, Ribeiro V, Peruhype MagalhÃ£es V, et al. Vaccination against canine leishmaniosis increases the phagocytic activity, nitric oxide production and expression of cell activation/migration molecules in neutrophils and monocytes. Vet Parasitol. 2016;220:33-45 pubmed publisher
Tham M, SchlÃ¶r G, Yerly D, Mueller C, Surbek D, Villiger P, et al. Reduced pro-inflammatory profile of Î³Î´T cells in pregnant patients with rheumatoid arthritis. Arthritis Res Ther. 2016;18:26 pubmed publisher
Rainard P, Cunha P, Ledresseur M, Staub C, TouzÃ© J, Kempf F, et al. Antigen-Specific Mammary Inflammation Depends on the Production of IL-17A and IFN-Î³ by Bovine CD4+ T Lymphocytes. PLoS ONE. 2015;10:e0137755 pubmed publisher
Kim J, Bae S, Song S, Chung K, Kwon S. Fiber composite slices for multiplexed immunoassays. Biomicrofluidics. 2015;9:044109 pubmed publisher
Wang W, Yen M, Liu K, Hsu P, Lin M, Chen P, et al. Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses. Stem Cell Reports. 2015;5:392-404 pubmed publisher
van Meijgaarden K, Haks M, Caccamo N, Dieli F, Ottenhoff T, Joosten S. Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset. PLoS Pathog. 2015;11:e1004671 pubmed publisher
Van Eyck L, De Somer L, Pombal D, Bornschein S, Frans G, Humblet Baron S, et al. Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency. Arthritis Rheumatol. 2015;67:1592-7 pubmed publisher
Kshirsagar S, Riedl M, Billing H, TÃ¶nshoff B, Thangavadivel S, Steuber C, et al. Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis. J Immunol. 2014;193:4895-903 pubmed publisher
Schubert D, Bode C, Kenefeck R, Hou T, Wing J, Kennedy A, et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med. 2014;20:1410-1416 pubmed publisher
Mehta N, Dagur P, ROSE S, Naik H, Stansky E, Doveikis J, et al. IL-17A production in human psoriatic blood and lesions by CD146+ T cells. J Invest Dermatol. 2015;135:311-314 pubmed publisher
Zhong H, Bao W, Friedman D, Yazdanbakhsh K. Hemin controls T cell polarization in sickle cell alloimmunization. J Immunol. 2014;193:102-10 pubmed publisher
Macleod A, Rudolph R, Corriden R, Ye I, Garijo O, Havran W. Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. J Immunol. 2014;192:5695-702 pubmed publisher
Li S, Joseph C, Becourt C, Klibi J, Luce S, Dubois Laforgue D, et al. Potential role of IL-17-producing iNKT cells in type 1 diabetes. PLoS ONE. 2014;9:e96151 pubmed publisher
Prodger J, Hirbod T, Kigozi G, Nalugoda F, Reynolds S, Galiwango R, et al. Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda. Mucosal Immunol. 2014;7:634-44 pubmed publisher
Boisson B, Wang C, Pedergnana V, Wu L, Cypowyj S, Rybojad M, et al. An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. Immunity. 2013;39:676-86 pubmed publisher
Geherin S, Lee M, Wilson R, Debes G. Ovine skin-recirculating ?? T cells express IFN-? and IL-17 and exit tissue independently of CCR7. Vet Immunol Immunopathol. 2013;155:87-97 pubmed publisher
Frentsch M, Stark R, Matzmohr N, Meier S, Durlanik S, Schulz A, et al. CD40L expression permits CD8+ T cells to execute immunologic helper functions. Blood. 2013;122:405-12 pubmed publisher
Chan Y, Chen K, Duncan S, Lathrop K, Latoche J, Logar A, et al. Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes. J Allergy Clin Immunol. 2013;131:1117-29, 1129.e1-5 pubmed publisher
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Velden J, Paust H, Hoxha E, Turner J, Steinmetz O, Wolf G, et al. Renal IL-17 expression in human ANCA-associated glomerulonephritis. Am J Physiol Renal Physiol. 2012;302:F1663-73 pubmed publisher
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Ma C, Dong X. Colorectal cancer-derived Foxp3(+) IL-17(+) T cells suppress tumour-specific CD8+ T cells. Scand J Immunol. 2011;74:47-51 pubmed publisher
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Brown M, Fintushel S, Lee M, Jennrich S, Geherin S, Hay J, et al. Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation. J Immunol. 2010;185:4873-82 pubmed publisher
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product information

Product Type :

Antibody

Product Name :

IL-17A Monoclonal Antibody (eBio64DEC17), eBioscience™

Catalog # :

14-7179-95

Quantity :

10 mg

Price (USD) :

3000.00 USD

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent

Species :

Human

Clone :

eBio64DEC17

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent

Aliases :

CTLA8; Ctla-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; Il17a; IL-17A; ILN; Interleukin; interleukin 17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin 17A-like; interleukin-17; Interleukin17A; interleukin-17A; LOC100339322; R-IL-17-A

more info or order :

Invitrogen product webpage