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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-17A Monoclonal Antibody (eBio17CK15A5), eBioscience™
catalog :
14-7175-81
quantity :
50µg
price :
US 96
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
eBio17CK15A5
reactivity :
mouse, rat
application :
ELISA
more info or order :
Invitrogen product webpage
citations: 20
Published Application/Species/Sample/DilutionReference
  • ELISA; mouse; fig 3D
Arellano B, Hussain R, Miller Little W, Herndon E, Lambracht Washington D, Eagar T, et al. A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB1*03:01 by a Murine TCR. PLoS ONE. 2016;11:e0152720 pubmed publisher
Lee P, Xin M, Pei W, Yang Y, Lovett Racke A. IL-3 Is a Marker of Encephalitogenic T Cells, but Not Essential for CNS Autoimmunity. Front Immunol. 2018;9:1255 pubmed publisher
Seki S, Stevenson M, Rosen A, Arandjelovic S, Gemta L, Bullock T, et al. Lineage-Specific Metabolic Properties and Vulnerabilities of T Cells in the Demyelinating Central Nervous System. J Immunol. 2017;198:4607-4617 pubmed publisher
Webb L, Amici S, Jablonski K, Savardekar H, Panfil A, Li L, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol. 2017;198:1439-1451 pubmed publisher
Ulland T, Jain N, Hornick E, Elliott E, Clay G, Sadler J, et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016;7:13180 pubmed publisher
Bittner Eddy P, Fischer L, Kaplan D, Thieu K, Costalonga M. Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis-Driven Alveolar Bone Destruction. J Immunol. 2016;197:1435-46 pubmed publisher
McAlees J, Lajoie S, Dienger K, Sproles A, Richgels P, Yang Y, et al. Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma. Eur J Immunol. 2015;45:1019-29 pubmed publisher
Arndt A, Hoffacker P, Zellmer K, Goecer O, Recks M, Kuerten S. Conventional housing conditions attenuate the development of experimental autoimmune encephalomyelitis. PLoS ONE. 2014;9:e99794 pubmed publisher
Martinez Llordella M, Esensten J, Bailey Bucktrout S, Lipsky R, Marini A, Chen J, et al. CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response. J Exp Med. 2013;210:1603-19 pubmed publisher
Garcia J, Pino P, Mizutani M, Cardona S, Charo I, Ransohoff R, et al. Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation. J Immunol. 2013;191:1063-72 pubmed publisher
Cascio J, Haymaker C, Divekar R, Zaghouani S, Khairallah M, Wan X, et al. Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance. J Immunol. 2013;190:6004-14 pubmed publisher
Shin K, Chung H, Kim D, Hwang J, Lee S. Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma. Life Sci. 2013;92:1093-9 pubmed publisher
Jung M, Kim H, Hong H, Youn B, Kim T. Adiponectin induces dendritic cell activation via PLC?/JNK/NF-?B pathways, leading to Th1 and Th17 polarization. J Immunol. 2012;188:2592-601 pubmed publisher
Massilamany C, Asojo O, Gangaplara A, Steffen D, Reddy J. Identification of a second mimicry epitope from Acanthamoeba castellanii that induces CNS autoimmunity by generating cross-reactive T cells for MBP 89-101 in SJL mice. Int Immunol. 2011;23:729-39 pubmed publisher
Massilamany C, Gangaplara A, Steffen D, Reddy J. Identification of novel mimicry epitopes for cardiac myosin heavy chain-? that induce autoimmune myocarditis in A/J mice. Cell Immunol. 2011;271:438-49 pubmed publisher
Jung M, Son M, Kim S, Cho D, Kim T. IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production. J Immunol. 2011;186:6848-59 pubmed publisher
Domingues H, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G. Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS ONE. 2010;5:e15531 pubmed publisher
Massilamany C, Steffen D, Reddy J. An epitope from Acanthamoeba castellanii that cross-react with proteolipid protein 139-151-reactive T cells induces autoimmune encephalomyelitis in SJL mice. J Neuroimmunol. 2010;219:17-24 pubmed publisher
Li M, O Sullivan K, Jones L, Lo C, Semple T, Kumanogoh A, et al. Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis. Immunology. 2009;128:114-22 pubmed publisher
Yamada Y, Sekine Y, Yoshida S, Yasufuku K, Petrache I, Benson H, et al. Type V collagen-induced oral tolerance plus low-dose cyclosporine prevents rejection of MHC class I and II incompatible lung allografts. J Immunol. 2009;183:237-45 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IL-17A Monoclonal Antibody (eBio17CK15A5), eBioscience™
Catalog # :
14-7175-81
Quantity :
50µg
Price :
US 96
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse, Rat
Applications :
ELISA: 1-4 µg/mL
Species :
Mouse, Rat
Clone :
eBio17CK15A5
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
Format :
Liquid
Applications w/Dilutions :
ELISA: 1-4 µg/mL
Aliases :
BOS_21471; CTLA8; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; IL17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A; interleukin 17A-like; interleukin-17; Interleukin17A; Interleukin-17A; LOC100339322; R-IL-17-A
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA