IL-13 Monoclonal Antibody (PVM13-1), eBioscience™ | Invitrogen 14-7139-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-13 Monoclonal Antibody (PVM13-1), eBioscience™

catalog :

14-7139-81

quantity :

50µg

price :

US 108

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PVM13-1

reactivity :

human

application :

ELISA, neutralization, flow cytometry

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 5	Simpson L, Patel S, Bhakta N, Choy D, Brightbill H, Ren X, et al. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014;15:1162-70 pubmed publisher
	Chang H, Liu G, Dwivedi N, Sun B, Okamoto Y, Kinslow J, et al. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. JCI Insight. 2016;1:e90045 pubmed publisher
	Watkin L, Jessen B, Wiszniewski W, Vece T, Jan M, Sha Y, et al. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet. 2015;47:654-60 pubmed publisher
	Price J, Haddon D, Kemmer D, Delepine G, Mandelbaum G, Jarrell J, et al. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J Clin Invest. 2013;123:5135-45 pubmed publisher
	Fuschiotti P, Larregina A, Ho J, Feghali Bostwick C, Medsger T. Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis. Arthritis Rheum. 2013;65:236-46 pubmed publisher
	Hansmann L, Schmidl C, Kett J, Steger L, Andreesen R, Hoffmann P, et al. Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression. J Immunol. 2012;188:1275-82 pubmed publisher
	Divekar A, Khanna D, Abtin F, Maranian P, Saggar R, Saggar R, et al. Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosis. Clin Immunol. 2011;141:293-303 pubmed publisher
	Medsger T, Ivanco D, Kardava L, Morel P, Lucas M, Fuschiotti P. GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production. Arthritis Rheum. 2011;63:1738-47 pubmed publisher
	Fuschiotti P, Medsger T, Morel P. Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis. Arthritis Rheum. 2009;60:1119-28 pubmed publisher
	Ma C, Chew G, Simpson N, Priyadarshi A, Wong M, Grimbacher B, et al. Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med. 2008;205:1551-7 pubmed publisher
	Yuan L, Wen K, Azevedo M, Gonzalez A, Zhang W, Saif L. Virus-specific intestinal IFN-gamma producing T cell responses induced by human rotavirus infection and vaccines are correlated with protection against rotavirus diarrhea in gnotobiotic pigs. Vaccine. 2008;26:3322-31 pubmed publisher
	Schloot N, Meierhoff G, Karlsson Faresjö M, Ott P, Putnam A, Lehmann P, et al. Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop. J Autoimmun. 2003;21:365-76 pubmed

product information

Product Type :

Antibody

Product Name :

IL-13 Monoclonal Antibody (PVM13-1), eBioscience™

Catalog # :

14-7139-81

Quantity :

50µg

Price :

US 108

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 1-4 µg/mL, Flow Cytometry: Assay-Dependent, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Human

Clone :

PVM13-1

Isotype :

IgG1

Storage :

4° C

Description :

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1-4 µg/mL, Flow Cytometry: Assay-Dependent, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

ALRH; ALRH antibody; BHR1; BOS_7773; il 13; Il13; Il-13; ILN; Interleukin; interleukin 13; Interleukin13; Interleukin-13; L13; MGC116786; MGC116788; MGC116789; NC30; NC30 antibody; P600; P600 antibody; T-cell activation protein P600

more info or order :

Invitrogen product webpage