product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-12/IL-23 p40 Monoclonal Antibody (C8.6), eBioscience™
catalog :
14-7129-85
quantity :
500µg
price :
US 247
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C8.6
reactivity :
human
application :
western blot, neutralization, flow cytometry, blocking or activating experiments
more info or order :
citations: 12
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; 10 ug/ml; fig 3
Tsai C, Liong K, Gunalan M, Li N, Lim D, Fisher D, et al. Type I IFNs and IL-18 regulate the antiviral response of primary human γδ T cells against dendritic cells infected with Dengue virus. J Immunol. 2015;194:3890-900 pubmed publisher
  • blocking or activating experiments; human; 2.5 ug/ml
Lim D, Yawata N, Selva K, Li N, Tsai C, Yeong L, et al. The combination of type I IFN, TNF-α, and cell surface receptor engagement with dendritic cells enables NK cells to overcome immune evasion by dengue virus. J Immunol. 2014;193:5065-75 pubmed publisher
  • blocking or activating experiments; human
de Groen R, Boltjes A, Hou J, Liu B, McPhee F, Friborg J, et al. IFN-λ-mediated IL-12 production in macrophages induces IFN-γ production in human NK cells. Eur J Immunol. 2015;45:250-9 pubmed publisher
  • blocking or activating experiments; human; 10 ug/ml
Deng N, Weaver J, Mosmann T. Cytokine diversity in the Th1-dominated human anti-influenza response caused by variable cytokine expression by Th1 cells, and a minor population of uncommitted IL-2+IFN?- Thpp cells. PLoS ONE. 2014;9:e95986 pubmed publisher
  • flow cytometry; human; 1 ug/ml; fig 3
Nagy L, Grishina I, Macal M, Hirao L, Hu W, Sankaran Walters S, et al. Chronic HIV infection enhances the responsiveness of antigen presenting cells to commensal Lactobacillus. PLoS ONE. 2013;8:e72789 pubmed publisher
  • blocking or activating experiments; human
Gorski K, Waller E, Bjornton Severson J, Hanten J, Riter C, Kieper W, et al. Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists. Int Immunol. 2006;18:1115-26 pubmed
Lopes D, Fernandes J, Cardoso T, Bafica A, Oliveira S, Carvalho E, et al. Dendritic cell profile induced by Schistosoma mansoni antigen in cutaneous leishmaniasis patients. Biomed Res Int. 2014;2014:743069 pubmed publisher
Wolfl M, Schwinn S, Yoo Y, Reß M, Braun M, Chopra M, et al. Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis. Blood. 2013;122:1203-13 pubmed publisher
Trott K, Richardson A, Hudgens M, Abel K. Immune activation and regulation in simian immunodeficiency virus-Plasmodium fragile-coinfected rhesus macaques. J Virol. 2013;87:9523-37 pubmed publisher
Olliver M, Hiew J, Mellroth P, Henriques Normark B, Bergman P. Human monocytes promote Th1 and Th17 responses to Streptococcus pneumoniae. Infect Immun. 2011;79:4210-7 pubmed publisher
Cho D, Lee W, Halloran P, Trinchieri G, Kim Y. Enhancement of porcine natural killer cell activity by recombinant human and murine IL-12. Cell Immunol. 1996;172:29-34 pubmed
Aragane Y, Riemann H, Bhardwaj R, Schwarz A, Sawada Y, Yamada H, et al. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 1994;153:5366-72 pubmed
product information
Product Type :
Antibody
Product Name :
IL-12/IL-23 p40 Monoclonal Antibody (C8.6), eBioscience™
Catalog # :
14-7129-85
Quantity :
500µg
Price :
US 247
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: Assay-Dependent, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: Assay-Dependent
Species :
Human
Clone :
C8.6
Isotype :
IgG1, kappa
Storage :
4° C
Description :
IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
BOS_5471; BOS_8400; CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12/IL 23p40; il 23; IL 23 p40; Il12; IL-12 subunit p40; IL12, subunit p40; Il12b; IL-12B; Il12p40; Il-12p40; il23; IL-23; IL23 p41; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; IMD28; IMD29; Interleukin; Interleukin 12; interleukin 12 40kDa subunit; interleukin 12, p40; interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; Interleukin12; interleukin-12 beta chain; interleukin-12 p40; interleukin-12 p40 subunit; Interleukin-12 subunit beta; interleukin-23 p19 subunit; Interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF2; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA