IL-12/IL-23 p40 Monoclonal Antibody (C15.6), eBioscience™ | Invitrogen 14-7125-85 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-12/IL-23 p40 Monoclonal Antibody (C15.6), eBioscience™

catalog :

14-7125-85

quantity :

500µg

price :

US 258

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

C15.6

reactivity :

mouse

application :

ELISA

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
ELISA; mouse; fig 1c	Napolitano A, van der Veen A, Bunyan M, Borg A, Frith D, Howell S, et al. Cysteine-Reactive Free ISG15 Generates IL-1β-Producing CD8α+ Dendritic Cells at the Site of Infection. J Immunol. 2018;201:604-614 pubmed publisher
	Shin K, Kataru R, Park H, Kwon B, Kim T, Hong Y, et al. TH2 cells and their cytokines regulate formation and function of lymphatic vessels. Nat Commun. 2015;6:6196 pubmed publisher
	Mosconi I, Geuking M, Zaiss M, Massacand J, Aschwanden C, Kwong Chung C, et al. Intestinal bacteria induce TSLP to promote mutualistic T-cell responses. Mucosal Immunol. 2013;6:1157-67 pubmed publisher
	Ricciardelli C, Frewin K, Tan I, Williams E, Opeskin K, Pritchard M, et al. The ADAMTS1 protease gene is required for mammary tumor growth and metastasis. Am J Pathol. 2011;179:3075-85 pubmed publisher
	Freigang S, Ampenberger F, Spohn G, Heer S, Shamshiev A, Kisielow J, et al. Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. Eur J Immunol. 2011;41:2040-51 pubmed publisher
	Couper K, Blount D, Hafalla J, Van Rooijen N, de Souza J, Riley E. Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia. Infect Immun. 2007;75:5806-18 pubmed
	Masek K, Fiore J, Leitges M, Yan S, Freedman B, Hunter C. Host cell Ca2+ and protein kinase C regulate innate recognition of Toxoplasma gondii. J Cell Sci. 2006;119:4565-73 pubmed
	Wysocka M, Kubin M, Vieira L, Ozmen L, Garotta G, Scott P, et al. Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur J Immunol. 1995;25:672-6 pubmed

product information

Product Type :

Antibody

Product Name :

IL-12/IL-23 p40 Monoclonal Antibody (C15.6), eBioscience™

Catalog # :

14-7125-85

Quantity :

500µg

Price :

US 258

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: 0.25-1 µg/mL

Species :

Mouse

Clone :

C15.6

Isotype :

IgG1

Storage :

4° C

Description :

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.25-1 µg/mL

Aliases :

BOS_5471; BOS_8400; CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12/IL 23p40; il 23; IL 23 p40; Il12; IL-12 subunit p40; IL12, subunit p40; Il12b; IL-12B; Il12p40; Il-12p40; il23; IL-23; IL23 p41; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; IMD28; IMD29; Interleukin; Interleukin 12; interleukin 12 40kDa subunit; interleukin 12, p40; interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; Interleukin12; interleukin-12 beta chain; interleukin-12 p40; interleukin-12 p40 subunit; Interleukin-12 subunit beta; interleukin-23 p19 subunit; Interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF2; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798

more info or order :

Invitrogen product webpage