IL-6 Monoclonal Antibody (MQ2-13A5), eBioscience™ | Invitrogen 14-7069-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-6 Monoclonal Antibody (MQ2-13A5), eBioscience™

catalog :

14-7069-81

quantity :

50µg

price :

US 85.5

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MQ2-13A5

reactivity :

human

application :

ELISA, flow cytometry, blocking or activating experiments, other

more info or order :

Invitrogen product webpage

citations: 34

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2b	Pangrazzi L, Meryk A, Naismith E, Koziel R, Lair J, Krismer M, et al. "Inflamm-aging" influences immune cell survival factors in human bone marrow. Eur J Immunol. 2017;47:481-492 pubmed publisher
other; human; loading ...; fig 6	Hageneder S, Bauch M, Dostalek J. Plasmonically amplified bioassay - Total internal reflection fluorescence vs. epifluorescence geometry. Talanta. 2016;156-157:225-231 pubmed publisher
flow cytometry; human; fig 2	Boltjes A, van Montfoort N, Biesta P, Op den Brouw M, Kwekkeboom J, van der Laan L, et al. Kupffer cells interact with hepatitis B surface antigen in vivo and in vitro, leading to proinflammatory cytokine production and natural killer cell function. J Infect Dis. 2015;211:1268-78 pubmed publisher
ELISA; human; fig 1	Buchegger P, Preininger C. Four assay designs and on-chip calibration: gadgets for a sepsis protein array. Anal Chem. 2014;86:3174-80 pubmed publisher
flow cytometry; human; 1 ug/ml; fig 3	Nagy L, Grishina I, Macal M, Hirao L, Hu W, Sankaran Walters S, et al. Chronic HIV infection enhances the responsiveness of antigen presenting cells to commensal Lactobacillus. PLoS ONE. 2013;8:e72789 pubmed publisher
blocking or activating experiments; human; tbl 1	Sharma S, Nemeth E, Chen Y, Goodnough J, Huston A, Roodman G, et al. Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res. 2008;14:3262-7 pubmed publisher
	Pringle E, Robinson C, McCormick C. Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis. J Virol. 2019;93: pubmed publisher
	Oh K, Gottschalk R, Lounsbury N, Sun J, Dorrington M, Baek S, et al. Dual Roles for Ikaros in Regulation of Macrophage Chromatin State and Inflammatory Gene Expression. J Immunol. 2018;201:757-771 pubmed publisher
	Glasner D, Ratnasiri K, Puerta Guardo H, Espinosa D, Beatty P, Harris E. Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components. PLoS Pathog. 2017;13:e1006673 pubmed publisher
	Jiang C, Zhang Q, Shanti R, Shi S, Chang T, Carrasco L, et al. Mesenchymal Stromal Cell-Derived Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Acquisition of Epithelial Stem-Like Cell Properties in Ameloblastoma Epithelial Cells. Stem Cells. 2017;35:2083-2094 pubmed publisher
	De Paoli M, Gogalic S, Sauer U, Preininger C, Pandha H, Simpson G, et al. Multiplatform Biomarker Discovery for Bladder Cancer Recurrence Diagnosis. Dis Markers. 2016;2016:4591910 pubmed
	Zhou Q, Yu X, Demirkaya E, Deuitch N, Stone D, Tsai W, et al. Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. Proc Natl Acad Sci U S A. 2016;113:10127-32 pubmed publisher
	Rossi O, Caboni M, Negrea A, Necchi F, Alfini R, Micoli F, et al. Toll-Like Receptor Activation by Generalized Modules for Membrane Antigens from Lipid A Mutants of Salmonella enterica Serovars Typhimurium and Enteritidis. Clin Vaccine Immunol. 2016;23:304-14 pubmed publisher
	Yeh C, Shun C, Kuo Y, Jung C, Hsieh S, Chiu Y, et al. Activated human valvular interstitial cells sustain interleukin-17 production to recruit neutrophils in infective endocarditis. Infect Immun. 2015;83:2202-12 pubmed publisher
	Rossi O, Pesce I, Giannelli C, Aprea S, Caboni M, Citiulo F, et al. Modulation of endotoxicity of Shigella generalized modules for membrane antigens (GMMA) by genetic lipid A modifications: relative activation of TLR4 and TLR2 pathways in different mutants. J Biol Chem. 2014;289:24922-35 pubmed publisher
	Boltjes A, Groothuismink Z, van Oord G, Janssen H, Woltman A, Boonstra A. Monocytes from chronic HBV patients react in vitro to HBsAg and TLR by producing cytokines irrespective of stage of disease. PLoS ONE. 2014;9:e97006 pubmed publisher
	Reichwald K, Jørgensen T, Tougaard P, Skov S. TL1A induces TCR independent IL-6 and TNF-? production and growth of PLZF? leukocytes. PLoS ONE. 2014;9:e85793 pubmed publisher
	Marr N, Wang T, Kam S, Hu Y, Sharma A, Lam A, et al. Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children. J Immunol. 2014;192:948-57 pubmed publisher
	Krishnan S, Wilson E, Sheikh V, Rupert A, Mendoza D, Yang J, et al. Evidence for innate immune system activation in HIV type 1-infected elite controllers. J Infect Dis. 2014;209:931-9 pubmed publisher
	Spaan M, Groothuismink Z, Koning L, Roomer R, Janssen H, de Knegt R, et al. Erythropoietin administration suppresses human monocyte function in vitro and during therapy-induced anemia in HCV patients. Antiviral Res. 2013;98:469-75 pubmed publisher
	Yeh C, Yeh T, Jung C, Chen P, Lien H, Chia J. Activated human nasal epithelial cells modulate specific antibody response against bacterial or viral antigens. PLoS ONE. 2013;8:e55472 pubmed publisher
	Jaudszus A, Gruen M, Watzl B, Ness C, Roth A, Lochner A, et al. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. J Lipid Res. 2013;54:923-35 pubmed publisher
	Vohra P, Poxton I. Induction of cytokines in a macrophage cell line by proteins of Clostridium difficile. FEMS Immunol Med Microbiol. 2012;65:96-104 pubmed publisher
	Sauer U, Domnanich P, Preininger C. Protein chip for the parallel quantification of high and low abundant biomarkers for sepsis. Anal Biochem. 2011;419:46-52 pubmed publisher
	Frazer L, O Connell C, Andrews C, Zurenski M, Darville T. Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection. Infect Immun. 2011;79:4029-41 pubmed publisher
	Domnanich P, Peña D, Preininger C. Xanthan/chitosan gold chip for metal enhanced protein biomarker detection. Biosens Bioelectron. 2011;26:2559-65 pubmed publisher
	Ma C, Ni L, Zhang Y, Zhang C, Wu X, Atia A, et al. PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection. Immunology. 2011;132:421-31 pubmed publisher
	Veltkamp M, van Moorsel C, Rijkers G, Ruven H, van den Bosch J, Grutters J. Toll-like receptor (TLR)-9 genetics and function in sarcoidosis. Clin Exp Immunol. 2010;162:68-74 pubmed publisher
	Wang J, Huizinga T, Toes R. De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid. J Immunol. 2009;183:4119-26 pubmed publisher
	Floriano P, Christodoulides N, Miller C, Ebersole J, Spertus J, Rose B, et al. Use of saliva-based nano-biochip tests for acute myocardial infarction at the point of care: a feasibility study. Clin Chem. 2009;55:1530-8 pubmed publisher
	Yan B, Ye S, Chen G, Kuang M, Shen N, Chen S. Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells. Arthritis Rheum. 2008;58:801-12 pubmed publisher
	Barrionuevo P, Cassataro J, Delpino M, Zwerdling A, Pasquevich K, García Samartino C, et al. Brucella abortus inhibits major histocompatibility complex class II expression and antigen processing through interleukin-6 secretion via Toll-like receptor 2. Infect Immun. 2008;76:250-62 pubmed
	Gaines Das R, Poole S. The international standard for interleukin-6. Evaluation in an international collaborative study. J Immunol Methods. 1993;160:147-53 pubmed
	Andersson J, Abrams J, Bjork L, Funa K, Litton M, Agren K, et al. Concomitant in vivo production of 19 different cytokines in human tonsils. Immunology. 1994;83:16-24 pubmed

product information

Product Type :

Antibody

Product Name :

IL-6 Monoclonal Antibody (MQ2-13A5), eBioscience™

Catalog # :

14-7069-81

Quantity :

50µg

Price :

US 85.5

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human

Applications :

ELISA: 2-8 µg/mL

Species :

Human

Clone :

MQ2-13A5

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.

Format :

Liquid

Applications w/Dilutions :

ELISA: 2-8 µg/mL

Aliases :

B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BOS_4106; BSF2; BSF-2; CDF; ChIL-6; CTL differentiation factor; EGM_12696; HGF; H-IL-6; HSF; Hybridoma growth factor; hypothetical protein; IFNB2; IFN-beta-2; IL6; Il-6; ILg6; ILN; Interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin BSF-2; Interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 protein; M-IL-6; R-IL-6

more info or order :

Invitrogen product webpage