IL-4 Monoclonal Antibody (8D4-8), eBioscience™ | Invitrogen 14-7049-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-4 Monoclonal Antibody (8D4-8), eBioscience™

catalog :

14-7049-81

quantity :

50µg

price :

US 85.5

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8D4-8

reactivity :

human

application :

ELISA, flow cytometry

more info or order :

Invitrogen product webpage

citations: 35

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 8d	Bal S, Bernink J, Nagasawa M, Groot J, Shikhagaie M, Golebski K, et al. IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs. Nat Immunol. 2016;17:636-45 pubmed publisher
flow cytometry; human; loading ...; fig 2a	James E, Gates T, LaFond R, Yamamoto S, Ni C, Mai D, et al. Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome. PLoS Pathog. 2016;12:e1005375 pubmed publisher
flow cytometry; human	Van Eyck L, Hershfield M, Pombal D, Kelly S, Ganson N, Moens L, et al. Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency. J Allergy Clin Immunol. 2015;135:283-7.e5 pubmed publisher
flow cytometry; human	Kamburova E, Koenen H, van den Hoogen M, Baas M, Joosten I, Hilbrands L. Longitudinal analysis of T and B cell phenotype and function in renal transplant recipients with or without rituximab induction therapy. PLoS ONE. 2014;9:e112658 pubmed publisher
	Chang H, Liu G, Dwivedi N, Sun B, Okamoto Y, Kinslow J, et al. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. JCI Insight. 2016;1:e90045 pubmed publisher
	Zhong F, Zhou N, Wu K, Guo Y, Tan W, Zhang H, et al. A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes. Nucleic Acids Res. 2015;43:10474-91 pubmed publisher
	Kshirsagar S, Riedl M, Billing H, TÃ¶nshoff B, Thangavadivel S, Steuber C, et al. Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis. J Immunol. 2014;193:4895-903 pubmed publisher
	Schubert D, Bode C, Kenefeck R, Hou T, Wing J, Kennedy A, et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med. 2014;20:1410-1416 pubmed publisher
	Li S, Joseph C, Becourt C, Klibi J, Luce S, Dubois Laforgue D, et al. Potential role of IL-17-producing iNKT cells in type 1 diabetes. PLoS ONE. 2014;9:e96151 pubmed publisher
	Weinstein J, Bertino S, Hernandez S, Poholek A, Teplitzky T, Nowyhed H, et al. B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen. J Immunol. 2014;192:3166-79 pubmed publisher
	Galindo Albarrán A, Ramirez Pliego O, Labastida Conde R, Melchy Pérez E, Liquitaya Montiel A, Esquivel Guadarrama F, et al. CD43 signals prepare human T cells to receive cytokine differentiation signals. J Cell Physiol. 2014;229:172-80 pubmed
	Lin G, Field J, Yu J, Ken R, Neuberg D, Nathan D, et al. NF-?B is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptors. PLoS ONE. 2013;8:e74664 pubmed publisher
	Mele D, Salmeron A, Ghosh S, Huang H, Bryant B, Lora J. BET bromodomain inhibition suppresses TH17-mediated pathology. J Exp Med. 2013;210:2181-90 pubmed publisher
	Blom L, Poulsen L. In vitro Th1 and Th2 cell polarization is severely influenced by the initial ratio of naïve and memory CD4+ T cells. J Immunol Methods. 2013;397:55-60 pubmed publisher
	Lozano E, Joller N, Cao Y, Kuchroo V, Hafler D. The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. J Immunol. 2013;191:3673-80 pubmed publisher
	Kamburova E, Koenen H, Borgman K, ten Berge I, Joosten I, Hilbrands L. A single dose of rituximab does not deplete B cells in secondary lymphoid organs but alters phenotype and function. Am J Transplant. 2013;13:1503-11 pubmed publisher
	Davtyan T, Poghosyan D, Sukiasyan A, Grant M. The anti-idiotypic antibody 1F7 stimulates monocyte interleukin-10 production and induces endotoxin tolerance. J Inflamm (Lond). 2013;10:14 pubmed publisher
	Jaudszus A, Gruen M, Watzl B, Ness C, Roth A, Lochner A, et al. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. J Lipid Res. 2013;54:923-35 pubmed publisher
	Vicetti Miguel R, Maryak S, Cherpes T. Brefeldin A, but not monensin, enables flow cytometric detection of interleukin-4 within peripheral T cells responding to ex vivo stimulation with Chlamydia trachomatis. J Immunol Methods. 2012;384:191-5 pubmed publisher
	Lozano E, Dominguez Villar M, Kuchroo V, Hafler D. The TIGIT/CD226 axis regulates human T cell function. J Immunol. 2012;188:3869-75 pubmed publisher
	Hansmann L, Schmidl C, Kett J, Steger L, Andreesen R, Hoffmann P, et al. Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression. J Immunol. 2012;188:1275-82 pubmed publisher
	Kamburova E, Koenen H, Boon L, Hilbrands L, Joosten I. In vitro?effects of rituximab on the proliferation, activation and differentiation of human B cells. Am J Transplant. 2012;12:341-50 pubmed publisher
	Khoo A, Joosten I, Michels M, Woestenenk R, Preijers F, He X, et al. 1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells. Immunology. 2011;134:459-68 pubmed publisher
	Luchansky M, Bailey R. Rapid, multiparameter profiling of cellular secretion using silicon photonic microring resonator arrays. J Am Chem Soc. 2011;133:20500-6 pubmed publisher
	Kalache S, Dinavahi R, Pinney S, Mehrotra A, Cunningham M, Heeger P. Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients. J Immunol. 2011;187:1023-30 pubmed publisher
	Kim H, Eyheramonho M, Pichavant M, Gonzalez Cambaceres C, Matangkasombut P, Cervio G, et al. A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans. J Clin Invest. 2011;121:1111-8 pubmed publisher
	Mattila J, Diedrich C, Lin P, Phuah J, Flynn J. Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation. J Immunol. 2011;186:3527-37 pubmed publisher
	Yadav M, Liebau E, Haldar C, Rathaur S. Identification of major antigenic peptide of filarial glutathione-S-transferase. Vaccine. 2011;29:1297-303 pubmed publisher
	Bratke K, Klein C, Kuepper M, Lommatzsch M, Virchow J. Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus. Allergy. 2011;66:386-95 pubmed publisher
	Diana J, Beaudoin L, Gautron A, Lehuen A. NKT and tolerance. Methods Mol Biol. 2011;677:193-206 pubmed publisher
	Morse M, McNeel D. Prostate cancer patients on androgen deprivation therapy develop persistent changes in adaptive immune responses. Hum Immunol. 2010;71:496-504 pubmed publisher
	Acosta Rodriguez E, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol. 2007;8:942-9 pubmed
	Chen Y, Yang C, Jin N, Xie Z, Tang Y, Fei L, et al. Terminal complement complex C5b-9-treated human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization. Eur J Immunol. 2007;37:167-76 pubmed
	Gasser O, Schmid T, Zenhaeusern G, Hess C. Cyclooxygenase regulates cell surface expression of CXCR3/1-storing granules in human CD4+ T cells. J Immunol. 2006;177:8806-12 pubmed
	Bird C, Wadhwa M, Thorpe R. Development of immunoassays for human interleukin 3 and interleukin 4, some of which discriminate between different recombinant DNA-derived molecules. Cytokine. 1991;3:562-7 pubmed

product information

Product Type :

Antibody

Product Name :

IL-4 Monoclonal Antibody (8D4-8), eBioscience™

Catalog # :

14-7049-81

Quantity :

50µg

Price :

US 85.5

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 1-4 µg/mL

Species :

Human

Clone :

8D4-8

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1-4 µg/mL

Aliases :

B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; Binetrakin; BOS_7769; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; Il4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; Interleukin4; Interleukin-4; interleukin-4 precursor; Lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra

more info or order :

Invitrogen product webpage